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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADIPOR2

Summary for ADIPOR2

Gene information	Gene symbol	ADIPOR2
	Ensembl ID	ENSG00000285070
	Entrez ID	79602
	Gene name	adiponectin receptor 2
	Synonyms	ACDCR2\|PAQR2
	Gene type	protein_coding
	UniProtAcc	Q86V24

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Dataset with differentially expressed gene: ADIPOR2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.564147	2.93e-02
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.250209	1.97e-14
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.426513	1.61e-36

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Expression of ADIPOR2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADIPOR2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADIPOR2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADIPOR2	hsa-miR-4713-5p	99.5179	NM_024551
ADIPOR2	hsa-miR-150-5p	98.9606	NM_024551
ADIPOR2	hsa-miR-2113	98.6712	NM_024551
ADIPOR2	hsa-miR-6814-5p	97.1272	NM_024551
ADIPOR2	hsa-miR-629-3p	97.0841	NM_024551
ADIPOR2	hsa-miR-4733-5p	96.9489	NM_024551
ADIPOR2	hsa-miR-200c-3p	96.3833	NM_024551
ADIPOR2	hsa-miR-429	96.3833	NM_024551
ADIPOR2	hsa-miR-200b-3p	96.3833	NM_024551
ADIPOR2	hsa-miR-218-5p	95.4965	NM_024551
ADIPOR2	hsa-miR-4717-5p	94.6666	NM_024551
ADIPOR2	hsa-miR-5584-5p	94.3977	NM_024551
ADIPOR2	hsa-miR-485-5p	94.335	NM_024551
ADIPOR2	hsa-miR-6884-5p	94.335	NM_024551
ADIPOR2	hsa-miR-186-3p	93.9898	NM_024551
ADIPOR2	hsa-miR-19a-3p	93.7647	NM_024551
ADIPOR2	hsa-miR-19b-3p	93.7647	NM_024551
ADIPOR2	hsa-miR-1283	93.7164	NM_024551
ADIPOR2	hsa-miR-26b-3p	92.838	NM_024551
ADIPOR2	hsa-miR-6760-5p	91.272	NM_024551
ADIPOR2	hsa-miR-6895-5p	91.0133	NM_024551
ADIPOR2	hsa-miR-5087	90.5418	NM_024551
ADIPOR2	hsa-miR-5701	90.1271	NM_024551
ADIPOR2	hsa-miR-6815-3p	89.8828	NM_024551
ADIPOR2	hsa-miR-449b-5p	89.6794	NM_024551
ADIPOR2	hsa-miR-34a-5p	89.6794	NM_024551
ADIPOR2	hsa-miR-449a	89.6794	NM_024551
ADIPOR2	hsa-miR-34c-5p	89.6794	NM_024551
ADIPOR2	hsa-miR-6809-3p	88.3781	NM_024551
ADIPOR2	hsa-miR-1913	87.8628	NM_024551
ADIPOR2	hsa-miR-181a-2-3p	86.8739	NM_024551
ADIPOR2	hsa-miR-3120-3p	86.7631	NM_024551
ADIPOR2	hsa-miR-4753-5p	86.2078	NM_024551
ADIPOR2	hsa-miR-3910	86.0416	NM_024551
ADIPOR2	hsa-miR-6768-3p	85.8929	NM_024551
ADIPOR2	hsa-miR-6761-5p	85.8818	NM_024551
ADIPOR2	hsa-miR-6867-3p	85.7703	NM_024551
ADIPOR2	hsa-miR-5589-3p	85.5326	NM_024551
ADIPOR2	hsa-miR-6513-3p	85.3879	NM_024551
ADIPOR2	hsa-miR-6509-3p	84.9279	NM_024551
ADIPOR2	hsa-miR-5680	84.559	NM_024551
ADIPOR2	hsa-miR-4677-5p	84.5036	NM_024551
ADIPOR2	hsa-miR-4474-3p	84.0632	NM_024551
ADIPOR2	hsa-miR-142-5p	84.0534	NM_024551
ADIPOR2	hsa-miR-5590-3p	84.0534	NM_024551
ADIPOR2	hsa-miR-519b-3p	83.8258	NM_024551
ADIPOR2	hsa-miR-519a-3p	83.8258	NM_024551
ADIPOR2	hsa-miR-519c-3p	83.8258	NM_024551
ADIPOR2	hsa-miR-4264	82.821	NM_024551
ADIPOR2	hsa-miR-202-3p	82.418	NM_024551

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Motifs and transcription factors (TFs) regulating ADIPOR2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADIPOR2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ADIPOR2	metacluster_172.23	ZBTB32; ZBTB32 (directAnnotation).
ADIPOR2	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
ADIPOR2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ADIPOR2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ADIPOR2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ADIPOR2	transfac_pro__M04617	ZBTB7A (directAnnotation).
ADIPOR2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ADIPOR2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ADIPOR2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ADIPOR2	transfac_pro__M07387	ZBTB7A (directAnnotation).
ADIPOR2	transfac_pro__M07436	WT1 (directAnnotation).
ADIPOR2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ADIPOR2	transfac_pro__M00716	ZBTB14 (directAnnotation).
ADIPOR2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ADIPOR2	hdpi__HIP2	UBE2K (directAnnotation).
ADIPOR2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ADIPOR2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ADIPOR2	transfac_pro__M04893	TAF1 (directAnnotation).
ADIPOR2	transfac_pro__M03876	ZBTB33 (directAnnotation).
ADIPOR2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ADIPOR2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ADIPOR2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ADIPOR2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ADIPOR2	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
ADIPOR2	transfac_pro__M04748	GABPA (directAnnotation).
ADIPOR2	hdpi__TP73	TP73 (directAnnotation).
ADIPOR2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
ADIPOR2	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
ADIPOR2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ADIPOR2	transfac_pro__M04950	EGR1 (directAnnotation).
ADIPOR2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
ADIPOR2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
ADIPOR2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
ADIPOR2	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
ADIPOR2	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
ADIPOR2	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."