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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ADH1B

Summary for ADH1B

Gene information	Gene symbol	ADH1B
	Ensembl ID	ENSG00000196616
	Entrez ID	125
	Gene name	alcohol dehydrogenase 1B (class I), beta polypeptide
	Synonyms	ADH2
	Gene type	protein_coding
	UniProtAcc	P00325

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Dataset with differentially expressed gene: ADH1B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.377935	2.98e-03

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Expression of ADH1B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADH1B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADH1B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADH1B	hsa-miR-511-3p	96.9121	NM_000668
ADH1B	hsa-miR-7152-5p	95.7705	NM_000668
ADH1B	hsa-miR-4314	92.7286	NM_000668
ADH1B	hsa-miR-450b-5p	92.219	NM_000668
ADH1B	hsa-miR-570-3p	91.1098	NM_000668
ADH1B	hsa-miR-3943	88.2904	NM_000668
ADH1B	hsa-miR-3160-3p	88.0863	NM_000668
ADH1B	hsa-miR-4524a-3p	87.7142	NM_000668
ADH1B	hsa-miR-3151-5p	85.4787	NM_000668
ADH1B	hsa-miR-1303	85.3411	NM_000668
ADH1B	hsa-miR-936	84.1454	NM_000668
ADH1B	hsa-miR-548aw	80.9913	NM_000668
ADH1B	hsa-miR-200b-3p	80.0734	NM_000668
ADH1B	hsa-miR-200c-3p	80.0734	NM_000668
ADH1B	hsa-miR-429	80.0734	NM_000668

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Motifs and transcription factors (TFs) regulating ADH1B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ADH1B	"4-Iodopyrazole"	DB02721	small molecule
ADH1B	"Cyclohexanol"	DB03703	small molecule
ADH1B	"Fomepizole"	DB01213	small molecule
ADH1B	"Glycerin"	DB09462	small molecule
ADH1B	"N-Benzylformamide"	DB02481	small molecule
ADH1B	"N-Heptylformamide"	DB04105	small molecule
ADH1B	"NADH"	DB00157	small molecule
ADH1B	"Nicotinamide adenine dinucleotide phosphate"	DB03461	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."