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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADGRG6

Summary for ADGRG6

Gene information	Gene symbol	ADGRG6
	Ensembl ID	ENSG00000112414
	Entrez ID	57211
	Gene name	adhesion G protein-coupled receptor G6
	Synonyms	FLJ14937\|GPR126
	Gene type	protein_coding
	UniProtAcc	Q86SQ4

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Dataset with differentially expressed gene: ADGRG6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.709739	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.418262	1.80e-19

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Expression of ADGRG6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADGRG6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADGRG6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADGRG6	hsa-miR-4719	97.2282	NM_001032394
ADGRG6	hsa-miR-587	93.361	NM_001032394
ADGRG6	hsa-miR-5585-3p	91.9678	NM_001032395
ADGRG6	hsa-miR-1279	90.8067	NM_001032395
ADGRG6	hsa-miR-2113	89.1839	NM_001032394
ADGRG6	hsa-miR-190a-3p	89.0768	NM_001032395
ADGRG6	hsa-miR-152-5p	88.6625	NM_001032395
ADGRG6	hsa-miR-5190	86.8932	NM_001032395
ADGRG6	hsa-miR-616-3p	86.6816	NM_001032395
ADGRG6	hsa-miR-217-5p	86.681	NM_001032395
ADGRG6	hsa-miR-6818-3p	86.5882	NM_001032395
ADGRG6	hsa-miR-6807-3p	86.1531	NM_001032395
ADGRG6	hsa-miR-513c-3p	85.5224	NM_001032394
ADGRG6	hsa-miR-513a-3p	85.5224	NM_001032394
ADGRG6	hsa-miR-4296	85.1004	NM_001032395
ADGRG6	hsa-miR-3606-3p	85.0974	NM_001032394
ADGRG6	hsa-miR-6730-3p	84.8067	NM_001032394
ADGRG6	hsa-miR-1275	84.7517	NM_001032395
ADGRG6	hsa-miR-513b-5p	84.5601	NM_001032394
ADGRG6	hsa-miR-6801-3p	84.4616	NM_001032395
ADGRG6	hsa-miR-6873-5p	83.6339	NM_001032395
ADGRG6	hsa-miR-5197-5p	83.1555	NM_001032395
ADGRG6	hsa-miR-5692a	82.5946	NM_001032394
ADGRG6	hsa-miR-6810-3p	82.5888	NM_001032395
ADGRG6	hsa-miR-6719-3p	82.327	NM_001032394
ADGRG6	hsa-miR-4265	81.813	NM_001032395
ADGRG6	hsa-miR-4322	81.813	NM_001032395
ADGRG6	hsa-miR-4263	81.1301	NM_001032394
ADGRG6	hsa-miR-888-3p	80.8641	NM_001032395
ADGRG6	hsa-miR-1250-3p	80.7448	NM_001032395
ADGRG6	hsa-miR-664a-3p	80.5458	NM_001032395

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Motifs and transcription factors (TFs) regulating ADGRG6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADGRG6	metacluster_135.11	NR2C2 (directAnnotation).
ADGRG6	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ADGRG6	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ADGRG6	cisbp__M00968	MTF2 (directAnnotation).
ADGRG6	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ADGRG6	cisbp__M00341	PAX6 (directAnnotation).
ADGRG6	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ADGRG6	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ADGRG6	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ADGRG6	metacluster_175.1	ZNF283 (directAnnotation).
ADGRG6	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ADGRG6	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ADGRG6	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ADGRG6	transfac_pro__M01199	TRIM28 (directAnnotation).
ADGRG6	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ADGRG6	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ADGRG6	transfac_pro__M03806	ZBTB7C (directAnnotation).
ADGRG6	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ADGRG6	transfac_pro__M02089	E2F3 (directAnnotation).
ADGRG6	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ADGRG6	transfac_pro__M04817	ZBTB33 (directAnnotation).
ADGRG6	tfdimers__MD00483	ZBTB14 (directAnnotation).
ADGRG6	cisbp__M07938	E2F1 (directAnnotation).
ADGRG6	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ADGRG6	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ADGRG6	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ADGRG6	jaspar__MA1122.1	TFDP1 (directAnnotation).
ADGRG6	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."