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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADGRF5

Summary for ADGRF5

Gene information	Gene symbol	ADGRF5
	Ensembl ID	ENSG00000069122
	Entrez ID	221395
	Gene name	adhesion G protein-coupled receptor F5
	Synonyms	DKFZp564O1923\|GPR116\|KIAA0758
	Gene type	protein_coding
	UniProtAcc	Q8IZF2

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Dataset with differentially expressed gene: ADGRF5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.586929	4.90e-26

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Expression of ADGRF5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADGRF5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADGRF5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADGRF5	hsa-miR-3667-3p	98.5043	NM_001098518
ADGRF5	hsa-miR-6888-3p	97.2074	NM_001098518
ADGRF5	hsa-miR-511-5p	96.9852	NM_001098518
ADGRF5	hsa-miR-6868-3p	94.7192	NM_001098518
ADGRF5	hsa-miR-26a-1-3p	93.9843	NM_001098518
ADGRF5	hsa-miR-26a-2-3p	93.9843	NM_001098518
ADGRF5	hsa-miR-329-3p	93.0464	NM_001098518
ADGRF5	hsa-miR-362-3p	93.0464	NM_001098518
ADGRF5	hsa-miR-7843-3p	92.9274	NM_001098518
ADGRF5	hsa-miR-942-5p	92.0605	NM_001098518
ADGRF5	hsa-miR-182-5p	91.8017	NM_001098518
ADGRF5	hsa-miR-130a-5p	91.5638	NM_001098518
ADGRF5	hsa-miR-148a-3p	90.1408	NM_001098518
ADGRF5	hsa-miR-152-3p	90.1408	NM_001098518
ADGRF5	hsa-miR-148b-3p	90.1408	NM_001098518
ADGRF5	hsa-miR-4786-3p	89.7793	NM_001098518
ADGRF5	hsa-miR-625-3p	89.588	NM_001098518
ADGRF5	hsa-miR-3120-5p	89.1019	NM_001098518
ADGRF5	hsa-miR-511-3p	88.403	NM_001098518
ADGRF5	hsa-miR-1248	87.8058	NM_001098518
ADGRF5	hsa-miR-1284	86.3961	NM_001098518
ADGRF5	hsa-miR-3189-3p	86.2286	NM_001098518
ADGRF5	hsa-miR-6807-5p	85.9128	NM_001098518
ADGRF5	hsa-miR-8059	85.2091	NM_001098518
ADGRF5	hsa-miR-8055	85.0261	NM_001098518
ADGRF5	hsa-miR-6851-3p	84.7744	NM_001098518
ADGRF5	hsa-miR-8084	84.092	NM_001098518
ADGRF5	hsa-miR-338-5p	83.6358	NM_001098518
ADGRF5	hsa-miR-6734-3p	83.3411	NM_001098518
ADGRF5	hsa-miR-3919	82.8967	NM_001098518
ADGRF5	hsa-miR-6830-3p	81.8919	NM_001098518
ADGRF5	hsa-miR-618	81.2646	NM_001098518
ADGRF5	hsa-miR-4789-5p	80.3713	NM_001098518

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Motifs and transcription factors (TFs) regulating ADGRF5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADGRF5	transfac_pro__M06085	ZNF26 (directAnnotation).

Page: 1

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."