Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADAMTS9

Summary for ADAMTS9

Gene information	Gene symbol	ADAMTS9
	Ensembl ID	ENSG00000163638
	Entrez ID	56999
	Gene name	ADAM metallopeptidase with thrombospondin type 1 motif 9
	Synonyms	KIAA1312
	Gene type	protein_coding
	UniProtAcc	Q9P2N4

Top

Dataset with differentially expressed gene: ADAMTS9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.288387	2.47e-20
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.327013	4.13e-21
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.355728	1.29e-08

Top

Expression of ADAMTS9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ADAMTS9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ADAMTS9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADAMTS9	hsa-miR-8485	99.9924	NM_001318781
ADAMTS9	hsa-miR-3941	99.5502	NM_001318781
ADAMTS9	hsa-miR-5682	99.3607	NM_001318781
ADAMTS9	hsa-miR-29a-3p	98.9228	NM_001318781
ADAMTS9	hsa-miR-29b-3p	98.9228	NM_001318781
ADAMTS9	hsa-miR-29c-3p	98.9228	NM_001318781
ADAMTS9	hsa-miR-12123	98.291	NM_001318781
ADAMTS9	hsa-miR-30a-5p	98.2375	NM_001318781
ADAMTS9	hsa-miR-30d-5p	98.2375	NM_001318781
ADAMTS9	hsa-miR-30c-5p	98.2375	NM_001318781
ADAMTS9	hsa-miR-30b-5p	98.2375	NM_001318781
ADAMTS9	hsa-miR-30e-5p	98.2375	NM_001318781
ADAMTS9	hsa-miR-499b-3p	96.1661	NM_001318781
ADAMTS9	hsa-miR-499a-3p	96.1661	NM_001318781
ADAMTS9	hsa-miR-511-3p	95.7491	NM_001318781
ADAMTS9	hsa-miR-4803	95.7021	NM_001318781
ADAMTS9	hsa-miR-6871-3p	94.9029	NM_001318781
ADAMTS9	hsa-miR-196a-1-3p	94.4068	NM_001318781
ADAMTS9	hsa-miR-329-3p	94.3774	NM_001318781
ADAMTS9	hsa-miR-362-3p	94.3774	NM_001318781
ADAMTS9	hsa-miR-603	94.3774	NM_001318781
ADAMTS9	hsa-miR-3924	93.6173	NM_001318781
ADAMTS9	hsa-miR-302c-5p	93.498	NM_001318781
ADAMTS9	hsa-miR-802	93.101	NM_001318781
ADAMTS9	hsa-miR-5683	92.1182	NM_001318781
ADAMTS9	hsa-miR-6880-5p	91.2586	NM_001318781
ADAMTS9	hsa-miR-4445-5p	91.1053	NM_001318781
ADAMTS9	hsa-miR-548n	90.9436	NM_001318781
ADAMTS9	hsa-miR-205-5p	90.6903	NM_001318781
ADAMTS9	hsa-miR-7847-3p	89.8138	NM_001318781
ADAMTS9	hsa-miR-9-5p	89.7459	NM_001318781
ADAMTS9	hsa-miR-4789-3p	87.6348	NM_001318781
ADAMTS9	hsa-miR-95-5p	85.8177	NM_001318781
ADAMTS9	hsa-miR-548az-5p	85.5177	NM_001318781
ADAMTS9	hsa-miR-548t-5p	85.5177	NM_001318781
ADAMTS9	hsa-miR-1236-3p	85.0083	NM_001318781
ADAMTS9	hsa-miR-1245b-3p	84.4168	NM_001318781
ADAMTS9	hsa-miR-1277-5p	83.9999	NM_001318781
ADAMTS9	hsa-miR-3714	83.6657	NM_001318781
ADAMTS9	hsa-miR-4531	82.8566	NM_001318781
ADAMTS9	hsa-miR-877-3p	82.3214	NM_001318781
ADAMTS9	hsa-miR-4455	80.8224	NM_001318781
ADAMTS9	hsa-miR-3978	80.5759	NM_001318781

Page: 1

Top

Motifs and transcription factors (TFs) regulating ADAMTS9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADAMTS9	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ADAMTS9	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
ADAMTS9	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ADAMTS9	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ADAMTS9	jaspar__MA1708.1	ETV7 (directAnnotation).
ADAMTS9	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
ADAMTS9	transfac_pro__M04862	NRF1 (directAnnotation).
ADAMTS9	jaspar__MA1932.1	HOXB13 (directAnnotation).
ADAMTS9	metacluster_81.7	CREB1 (directAnnotation).
ADAMTS9	transfac_pro__M00492	STAT1 (directAnnotation).
ADAMTS9	transfac_pro__M04848	TAF1 (directAnnotation).
ADAMTS9	transfac_pro__M07260	IKZF1 (directAnnotation).
ADAMTS9	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
ADAMTS9	transfac_pro__M07270	TEAD4 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."