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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADAMTS1

Summary for ADAMTS1

Gene information	Gene symbol	ADAMTS1
	Ensembl ID	ENSG00000154734
	Entrez ID	9510
	Gene name	ADAM metallopeptidase with thrombospondin type 1 motif 1
	Synonyms	C3-C5\|KIAA1346\|METH1
	Gene type	protein_coding
	UniProtAcc	Q9UHI8

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Dataset with differentially expressed gene: ADAMTS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.524087	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.305299	0.00e+00

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Expression of ADAMTS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADAMTS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADAMTS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADAMTS1	hsa-miR-568	99.6761	NM_006988
ADAMTS1	hsa-miR-802	98.8203	NM_006988
ADAMTS1	hsa-miR-548j-5p	97.9115	NM_006988
ADAMTS1	hsa-miR-548ap-5p	97.9115	NM_006988
ADAMTS1	hsa-miR-548k	97.663	NM_006988
ADAMTS1	hsa-miR-548av-5p	97.663	NM_006988
ADAMTS1	hsa-miR-8054	97.663	NM_006988
ADAMTS1	hsa-miR-559	97.6451	NM_006988
ADAMTS1	hsa-miR-548ay-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548i	96.6587	NM_006988
ADAMTS1	hsa-miR-548ar-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548o-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548ab	96.6587	NM_006988
ADAMTS1	hsa-miR-548au-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548as-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548h-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548a-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548aq-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548bb-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548ad-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548ak	96.6587	NM_006988
ADAMTS1	hsa-miR-548b-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548c-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548d-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548am-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-548y	96.6587	NM_006988
ADAMTS1	hsa-miR-548w	96.6587	NM_006988
ADAMTS1	hsa-miR-548ae-5p	96.6587	NM_006988
ADAMTS1	hsa-miR-142-5p	95.2309	NM_006988
ADAMTS1	hsa-miR-5590-3p	95.1157	NM_006988
ADAMTS1	hsa-miR-9986	94.317	NM_006988
ADAMTS1	hsa-miR-1294	94.317	NM_006988
ADAMTS1	hsa-miR-548l	94.0733	NM_006988
ADAMTS1	hsa-miR-5684	89.9731	NM_006988
ADAMTS1	hsa-miR-4637	89.5809	NM_006988
ADAMTS1	hsa-miR-3927-5p	89.3864	NM_006988
ADAMTS1	hsa-miR-4803	87.1792	NM_006988
ADAMTS1	hsa-miR-6131	86.3351	NM_006988
ADAMTS1	hsa-miR-4733-3p	86.2027	NM_006988
ADAMTS1	hsa-miR-3688-3p	86.0689	NM_006988
ADAMTS1	hsa-miR-335-3p	85.7937	NM_006988
ADAMTS1	hsa-miR-628-3p	85.0533	NM_006988
ADAMTS1	hsa-miR-5580-3p	85.0469	NM_006988
ADAMTS1	hsa-miR-340-5p	84.4828	NM_006988
ADAMTS1	hsa-miR-670-3p	84.4351	NM_006988
ADAMTS1	hsa-miR-1248	84.3344	NM_006988
ADAMTS1	hsa-miR-4768-5p	84.2154	NM_006988
ADAMTS1	hsa-miR-548c-3p	84.0038	NM_006988
ADAMTS1	hsa-miR-6833-3p	83.1293	NM_006988
ADAMTS1	hsa-miR-3163	82.4507	NM_006988

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Motifs and transcription factors (TFs) regulating ADAMTS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADAMTS1	metacluster_151.2	ZNF23 (directAnnotation).
ADAMTS1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ADAMTS1	transfac_pro__M05479	ZNF580 (directAnnotation).
ADAMTS1	hdpi__ETV4	ETV4 (directAnnotation).
ADAMTS1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ADAMTS1	jaspar__MA0079.5	SP1 (directAnnotation).
ADAMTS1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
ADAMTS1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ADAMTS1	transfac_pro__M02089	E2F3 (directAnnotation).
ADAMTS1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ADAMTS1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
ADAMTS1	tfdimers__MD00483	ZBTB14 (directAnnotation).
ADAMTS1	cisbp__M07938	E2F1 (directAnnotation).
ADAMTS1	cisbp__M00968	MTF2 (directAnnotation).
ADAMTS1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ADAMTS1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."