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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADAM23

Summary for ADAM23

Gene information	Gene symbol	ADAM23
	Ensembl ID	ENSG00000114948
	Entrez ID	8745
	Gene name	ADAM metallopeptidase domain 23
	Synonyms	MDC3
	Gene type	protein_coding
	UniProtAcc	O75077

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Dataset with differentially expressed gene: ADAM23

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.779965	0.00e+00

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Expression of ADAM23 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADAM23

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADAM23

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADAM23	hsa-miR-5010-3p	98.7037	NM_003812
ADAM23	hsa-miR-4325	98.3362	NM_003812
ADAM23	hsa-miR-302c-5p	97.5758	NM_003812
ADAM23	hsa-miR-3143	97.2142	NM_003812
ADAM23	hsa-miR-493-5p	95.7748	NM_003812
ADAM23	hsa-miR-153-3p	94.4791	NM_003812
ADAM23	hsa-miR-2113	94.3634	NM_003812
ADAM23	hsa-miR-4775	93.3036	NM_003812
ADAM23	hsa-miR-23a-3p	92.6096	NM_003812
ADAM23	hsa-miR-23b-3p	92.6096	NM_003812
ADAM23	hsa-miR-520d-5p	92.5392	NM_003812
ADAM23	hsa-miR-524-5p	92.5392	NM_003812
ADAM23	hsa-miR-489-3p	92.5305	NM_003812
ADAM23	hsa-miR-548c-3p	92.5132	NM_003812
ADAM23	hsa-miR-548at-5p	92.3459	NM_003812
ADAM23	hsa-miR-1297	91.799	NM_003812
ADAM23	hsa-miR-6079	91.6839	NM_003812
ADAM23	hsa-miR-3913-3p	91.6441	NM_003812
ADAM23	hsa-miR-4450	90.8542	NM_003812
ADAM23	hsa-miR-26a-5p	90.6647	NM_003812
ADAM23	hsa-miR-26b-5p	90.6647	NM_003812
ADAM23	hsa-miR-587	90.3344	NM_003812
ADAM23	hsa-miR-23c	90.0103	NM_003812
ADAM23	hsa-miR-6739-5p	89.7388	NM_003812
ADAM23	hsa-miR-6733-5p	89.7388	NM_003812
ADAM23	hsa-miR-448	89.3924	NM_003812
ADAM23	hsa-miR-3670	88.7647	NM_003812
ADAM23	hsa-miR-3153	88.5122	NM_003812
ADAM23	hsa-miR-4465	88.3209	NM_003812
ADAM23	hsa-miR-6828-5p	87.6283	NM_003812
ADAM23	hsa-miR-4252	87.4997	NM_003812
ADAM23	hsa-miR-148b-3p	86.9475	NM_003812
ADAM23	hsa-miR-148a-3p	86.9475	NM_003812
ADAM23	hsa-miR-152-3p	86.9475	NM_003812
ADAM23	hsa-miR-3120-3p	86.8925	NM_003812
ADAM23	hsa-miR-5584-5p	86.8464	NM_003812
ADAM23	hsa-miR-7849-3p	86.5766	NM_003812
ADAM23	hsa-miR-5689	86.1271	NM_003812
ADAM23	hsa-miR-1912-3p	85.8858	NM_003812
ADAM23	hsa-miR-6810-5p	85.7236	NM_003812
ADAM23	hsa-miR-4694-3p	85.7211	NM_003812
ADAM23	hsa-miR-6779-3p	85.5388	NM_003812
ADAM23	hsa-miR-6072	85.3761	NM_003812
ADAM23	hsa-miR-4789-5p	84.9387	NM_003812
ADAM23	hsa-miR-3680-3p	83.7619	NM_003812
ADAM23	hsa-miR-6867-5p	83.4322	NM_003812
ADAM23	hsa-miR-103a-3p	83.2284	NM_003812
ADAM23	hsa-miR-107	83.2284	NM_003812
ADAM23	hsa-miR-1295b-5p	82.3482	NM_003812
ADAM23	hsa-miR-208a-5p	82.129	NM_003812

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Motifs and transcription factors (TFs) regulating ADAM23

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADAM23	transfac_pro__M04950	EGR1 (directAnnotation).
ADAM23	metacluster_55.5	ZNF541 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."