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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADAM19

Summary for ADAM19

Gene information	Gene symbol	ADAM19
	Ensembl ID	ENSG00000135074
	Entrez ID	8728
	Gene name	ADAM metallopeptidase domain 19
	Synonyms	MLTNB
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ADAM19

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.51886	6.57e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.380977	0.00e+00

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Expression of ADAM19 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADAM19

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADAM19

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADAM19	hsa-miR-498-3p	98.9245	NM_033274
ADAM19	hsa-miR-6760-5p	98.8705	NM_033274
ADAM19	hsa-miR-3680-3p	97.9023	NM_033274
ADAM19	hsa-miR-6851-5p	97.8457	NM_033274
ADAM19	hsa-miR-3689d	97.2172	NM_033274
ADAM19	hsa-miR-30a-5p	96.4174	NM_033274
ADAM19	hsa-miR-30d-5p	96.4174	NM_033274
ADAM19	hsa-miR-30e-5p	96.4174	NM_033274
ADAM19	hsa-miR-30c-5p	96.4174	NM_033274
ADAM19	hsa-miR-30b-5p	96.4174	NM_033274
ADAM19	hsa-miR-145-5p	95.9507	NM_033274
ADAM19	hsa-miR-4510	94.7296	NM_033274
ADAM19	hsa-miR-6127	94.7296	NM_033274
ADAM19	hsa-miR-6129	94.7296	NM_033274
ADAM19	hsa-miR-6133	94.7296	NM_033274
ADAM19	hsa-miR-6130	94.7296	NM_033274
ADAM19	hsa-miR-5195-3p	94.4079	NM_033274
ADAM19	hsa-miR-7150	94.2413	NM_033274
ADAM19	hsa-miR-6830-5p	94.2165	NM_033274
ADAM19	hsa-miR-92a-3p	94.1976	NM_033274
ADAM19	hsa-miR-32-5p	94.1976	NM_033274
ADAM19	hsa-miR-92b-3p	94.1976	NM_033274
ADAM19	hsa-miR-150-5p	94.0005	NM_033274
ADAM19	hsa-miR-450b-5p	93.867	NM_033274
ADAM19	hsa-miR-1297	92.8765	NM_033274
ADAM19	hsa-miR-507	92.6908	NM_033274
ADAM19	hsa-miR-26b-5p	91.9274	NM_033274
ADAM19	hsa-miR-26a-5p	91.9274	NM_033274
ADAM19	hsa-miR-25-3p	91.7029	NM_033274
ADAM19	hsa-miR-363-3p	91.7029	NM_033274
ADAM19	hsa-miR-367-3p	91.7029	NM_033274
ADAM19	hsa-miR-153-3p	91.6429	NM_033274
ADAM19	hsa-miR-4441	90.3293	NM_033274
ADAM19	hsa-miR-557	89.9697	NM_033274
ADAM19	hsa-miR-4465	89.2095	NM_033274
ADAM19	hsa-miR-6847-5p	89.0783	NM_033274
ADAM19	hsa-miR-4690-5p	87.5556	NM_033274
ADAM19	hsa-miR-4677-3p	87.3511	NM_033274
ADAM19	hsa-miR-4324	86.8464	NM_033274
ADAM19	hsa-miR-6507-5p	86.0141	NM_033274
ADAM19	hsa-miR-6851-3p	85.9715	NM_033274
ADAM19	hsa-let-7c-3p	85.8113	NM_033274
ADAM19	hsa-miR-486-3p	85.3249	NM_033274
ADAM19	hsa-miR-5702	85.0274	NM_033274
ADAM19	hsa-miR-4316	83.5564	NM_033274
ADAM19	hsa-miR-6754-5p	83.3002	NM_033274
ADAM19	hsa-miR-2276-3p	82.8181	NM_033274
ADAM19	hsa-miR-10526-3p	82.0148	NM_033274
ADAM19	hsa-miR-6878-5p	81.9246	NM_033274
ADAM19	hsa-miR-4728-5p	81.8803	NM_033274

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Motifs and transcription factors (TFs) regulating ADAM19

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADAM19	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ADAM19	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ADAM19	transfac_pro__M04617	ZBTB7A (directAnnotation).
ADAM19	transfac_pro__M07436	WT1 (directAnnotation).
ADAM19	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ADAM19	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ADAM19	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ADAM19	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ADAM19	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ADAM19	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ADAM19	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."