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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADAM12

Summary for ADAM12

Gene information	Gene symbol	ADAM12
	Ensembl ID	ENSG00000148848
	Entrez ID	8038
	Gene name	ADAM metallopeptidase domain 12
	Synonyms	MCMPMltna\|MLTN
	Gene type	protein_coding
	UniProtAcc	O43184

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Dataset with differentially expressed gene: ADAM12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.23517	1.68e-11
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.333792	1.71e-13

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Expression of ADAM12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADAM12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADAM12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADAM12	hsa-miR-548e-5p	97.8225	NM_001288973
ADAM12	hsa-miR-4728-5p	97.6262	NM_001288973
ADAM12	hsa-miR-6785-5p	97.6262	NM_001288973
ADAM12	hsa-miR-6883-5p	97.1015	NM_001288973
ADAM12	hsa-miR-149-3p	97.1015	NM_001288973
ADAM12	hsa-miR-759	95.5972	NM_001288973
ADAM12	hsa-miR-8057	94.5238	NM_001288973
ADAM12	hsa-miR-4679	94.3958	NM_001288973
ADAM12	hsa-miR-6894-5p	94.2628	NM_001288973
ADAM12	hsa-miR-2116-5p	92.9559	NM_001288973
ADAM12	hsa-miR-605-3p	92.8997	NM_001288973
ADAM12	hsa-miR-4716-5p	92.8703	NM_001288975
ADAM12	hsa-miR-6837-3p	92.7557	NM_001288973
ADAM12	hsa-miR-767-5p	92.3148	NM_001288973
ADAM12	hsa-miR-203a-3p	92.2078	NM_001288973
ADAM12	hsa-miR-6867-5p	91.7022	NM_001288973
ADAM12	hsa-miR-4768-3p	91.5908	NM_001288973
ADAM12	hsa-miR-150-3p	91.1766	NM_001288973
ADAM12	hsa-miR-5584-3p	90.4997	NM_001288973
ADAM12	hsa-miR-6501-3p	90.3838	NM_001288975
ADAM12	hsa-miR-1208	90.2333	NM_001288973
ADAM12	hsa-miR-6740-3p	90.1138	NM_001288973
ADAM12	hsa-miR-4709-3p	89.6001	NM_001288973
ADAM12	hsa-miR-765	89.2153	NM_001288973
ADAM12	hsa-miR-7154-3p	88.5835	NM_001288973
ADAM12	hsa-miR-15a-3p	88.5315	NM_001288973
ADAM12	hsa-miR-4328	88.3938	NM_001288973
ADAM12	hsa-miR-1-3p	88.3252	NM_001288973
ADAM12	hsa-miR-206	88.3252	NM_001288973
ADAM12	hsa-miR-4684-5p	87.9437	NM_001288973
ADAM12	hsa-miR-454-3p	87.3604	NM_001288973
ADAM12	hsa-miR-4712-3p	87.1538	NM_001288973
ADAM12	hsa-miR-766-5p	87.0932	NM_001288973
ADAM12	hsa-miR-11181-3p	87.0892	NM_001288973
ADAM12	hsa-miR-3161	86.8807	NM_001288973
ADAM12	hsa-miR-3658	86.3457	NM_001288973
ADAM12	hsa-miR-3148	86.0742	NM_001288973
ADAM12	hsa-miR-629-5p	85.8218	NM_001288973
ADAM12	hsa-miR-4652-3p	85.798	NM_001288973
ADAM12	hsa-miR-6822-3p	85.7857	NM_001288973
ADAM12	hsa-miR-613	85.0871	NM_001288973
ADAM12	hsa-miR-4529-5p	84.9767	NM_001288973
ADAM12	hsa-miR-6502-5p	84.7725	NM_001288973
ADAM12	hsa-miR-1301-5p	84.7725	NM_001288973
ADAM12	hsa-miR-4724-3p	84.6478	NM_001288973
ADAM12	hsa-miR-760	84.6333	NM_001288973
ADAM12	hsa-miR-12123	84.381	NM_001288973
ADAM12	hsa-miR-4766-5p	84.3477	NM_001288973
ADAM12	hsa-miR-9902	84.3075	NM_001288973
ADAM12	hsa-miR-548m	84.099	NM_001288973

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Motifs and transcription factors (TFs) regulating ADAM12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADAM12	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ADAM12	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ADAM12	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ADAM12	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ADAM12	transfac_pro__M07387	ZBTB7A (directAnnotation).
ADAM12	transfac_pro__M07436	WT1 (directAnnotation).
ADAM12	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ADAM12	hdpi__HIP2	UBE2K (directAnnotation).
ADAM12	transfac_pro__M03876	ZBTB33 (directAnnotation).
ADAM12	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ADAM12	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ADAM12	metacluster_134.3	FOXA1; FOXA1; FOXC1; FOXG1; FOXG1; FOXI1; FOXJ3; FOXJ3; FOXJ3; FOXK2; FOXL2; FOXO1; FOXO1; FOXO1; FOXO3; FOXO3; FOXO4; FOXO4; FOXO4; FOXP1; FOXP1; FOXP2; FOXP2; FOXP2 (directAnnotation). FOXD1; FOXJ2; FOXJ2; FOXJ3; FOXK1; FOXL2; FOXL2; FOXL2; FOXO1; FOXO3; FOXO3; FOXP2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."