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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target

Gene: ADA

Summary for ADA

Gene informationGene symbol

ADA

Ensembl ID

ENSG00000196839

Entrez ID

100

Gene nameadenosine deaminase
SynonymsADA1
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: ADA

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE163836

FCIBC02 cell lineCell lineBreast cancerInflammatory breast cancerChemotherapypaclitaxelNAMalignant cells-0.2783090.00e+00

GSE153697

patientsBone marrow aspirateAcute lymphoblastic leukemiaRelapsed B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyanti-CD19 CAR-TNAMalignant cells0.4443891.00e-27

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreB cells-0.4776635.11e-05

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells0.2634770.00e+00

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Expression of ADA in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to ADA

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADA

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
ADAhsa-miR-453394.4521NM_001322050
ADAhsa-miR-3663-3p84.6243NM_001322050
ADAhsa-miR-30d-3p83.1897NM_001322050
ADAhsa-miR-30e-3p83.1897NM_001322050
ADAhsa-miR-30a-3p83.1897NM_001322050
ADAhsa-miR-3064-3p81.4592NM_001322050
Page: 1

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Motifs and transcription factors (TFs) regulating ADA

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
ADAmetacluster_119.2CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
ADAtransfac_pro__M05521ZNF398 (directAnnotation).
ADAmetacluster_72.10ZNF697 (directAnnotation).
ADAmetacluster_168.18ZNF214; ZNF239; ZNF45; ZNF696 (directAnnotation).
ADAjaspar__MA1954.1FOXO1 (directAnnotation).
ADAtransfac_pro__M06372ZNF841 (directAnnotation).
ADAjaspar__MA1955.1FOXO1 (directAnnotation).
ADAdbtfbs__ZFP91_K562_ENCSR898XMH_merged_N1ZFP91 (directAnnotation).
ADAtaipale__ELK1_full_NACTTCCGSCGGAARMN_reprELK1 (directAnnotation).
ADAtransfac_pro__M05706ZNF20 (directAnnotation).
Page: 1

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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.
Target nameDrug nameDrug IDDrug type
ADA"(2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol"

DB07711

small molecule
ADA"1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARB

DB07783

small molecule
ADA"1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARB

DB07786

small molecule
ADA"1-Deaza-Adenosine"

DB04218

small molecule
ADA"1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE"

DB07785

small molecule
ADA"6-hydroxy-1,6-dihydro purine nucleoside"

DB03015

small molecule
ADA"7,8-dihydroinosine"

DB02472

small molecule
ADA"Dipyridamole"

DB00975

small molecule
ADA"FR-234938"

DB03220

small molecule
ADA"FR117016"

DB02616

small molecule
ADA"FR221647"

DB02096

small molecule
ADA"FR230513"

DB03572

small molecule
ADA"FR236913"

DB02830

small molecule
ADA"FR239087"

DB03370

small molecule
ADA"Nebularine"

DB04440

small molecule
ADA"Pentostatin"

DB00552

small molecule
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."