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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ACYP2

Summary for ACYP2

Gene information	Gene symbol	ACYP2
	Ensembl ID	ENSG00000170634
	Entrez ID	98
	Gene name	acylphosphatase 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ACYP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.59882	4.90e-14
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.389057	3.61e-31
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.401946	1.82e-21
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.517057	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.344698	0.00e+00

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Expression of ACYP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ACYP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ACYP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ACYP2	hsa-miR-8485	97.476	NM_001320590
ACYP2	hsa-miR-3529-3p	96.1413	NM_001320590
ACYP2	hsa-miR-144-3p	95.9477	NM_138448
ACYP2	hsa-miR-3686	95.7433	NM_001320590
ACYP2	hsa-miR-196a-1-3p	94.763	NM_001320590
ACYP2	hsa-miR-548a-3p	94.7127	NM_001320590
ACYP2	hsa-miR-548f-3p	94.7127	NM_001320590
ACYP2	hsa-miR-548ar-3p	94.6547	NM_001320590
ACYP2	hsa-miR-371b-5p	93.5688	NM_001320590
ACYP2	hsa-miR-616-5p	93.5688	NM_001320590
ACYP2	hsa-miR-373-5p	93.5688	NM_001320590
ACYP2	hsa-miR-548bc	93.539	NM_001320590
ACYP2	hsa-miR-548az-3p	93.539	NM_001320590
ACYP2	hsa-miR-548e-3p	93.539	NM_001320590
ACYP2	hsa-miR-8084	93.3279	NM_001320589
ACYP2	hsa-miR-584-5p	92.0989	NM_138448
ACYP2	hsa-miR-4709-3p	90.9206	NM_138448
ACYP2	hsa-miR-2116-5p	90.5839	NM_001320590
ACYP2	hsa-miR-889-3p	89.8698	NM_001320590
ACYP2	hsa-miR-4282	88.4629	NM_001320590
ACYP2	hsa-miR-802	87.6823	NM_138448
ACYP2	hsa-miR-6847-5p	87.5809	NM_138448
ACYP2	hsa-miR-548x-5p	87.2774	NM_001320590
ACYP2	hsa-miR-548aj-5p	87.2774	NM_001320590
ACYP2	hsa-miR-548g-5p	87.2774	NM_001320590
ACYP2	hsa-miR-548f-5p	87.2774	NM_001320590
ACYP2	hsa-miR-6509-5p	86.7375	NM_001320590
ACYP2	hsa-miR-4709-5p	86.6718	NM_138448
ACYP2	hsa-miR-6733-3p	86.4885	NM_138448
ACYP2	hsa-miR-4272	86.199	NM_001320590
ACYP2	hsa-miR-6507-5p	85.9715	NM_001320590
ACYP2	hsa-miR-641	85.2081	NM_001320590
ACYP2	hsa-miR-3617-5p	85.2081	NM_001320590
ACYP2	hsa-miR-548l	85.0588	NM_001320590
ACYP2	hsa-miR-451b	85.056	NM_001320590
ACYP2	hsa-miR-7-1-3p	84.4752	NM_138448
ACYP2	hsa-miR-7-2-3p	84.4752	NM_138448
ACYP2	hsa-miR-6853-3p	82.6336	NM_138448
ACYP2	hsa-miR-4713-3p	82.2757	NM_001320590
ACYP2	hsa-miR-4302	82.1234	NM_138448
ACYP2	hsa-miR-589-3p	81.7084	NM_138448
ACYP2	hsa-miR-7843-3p	80.7158	NM_001320590

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Motifs and transcription factors (TFs) regulating ACYP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ACYP2	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
ACYP2	transfac_pro__M00716	ZBTB14 (directAnnotation).
ACYP2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ACYP2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ACYP2	transfac_pro__M04893	TAF1 (directAnnotation).
ACYP2	transfac_pro__M03876	ZBTB33 (directAnnotation).
ACYP2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ACYP2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ACYP2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ACYP2	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
ACYP2	metacluster_22.17	NFE2 (directAnnotation).
ACYP2	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
ACYP2	metacluster_22.11	NFE2 (directAnnotation).
ACYP2	tfdimers__MD00490	CDX2; SOX2 (directAnnotation).
ACYP2	metacluster_22.39	NFE2L2 (directAnnotation).
ACYP2	metacluster_22.13	MAFK (inferredBy_Orthology).
ACYP2	metacluster_187.7	FEZF1; FEZF1; ZNF384; ZNF384; ZNF384 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
ACYP2	transfac_pro__M06404	ZNF497 (directAnnotation).
ACYP2	jaspar__MA0079.5	SP1 (directAnnotation).
ACYP2	cisbp__M07938	E2F1 (directAnnotation).
ACYP2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ACYP2	transfac_pro__M04826	EP300 (directAnnotation).
ACYP2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
ACYP2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
ACYP2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ACYP2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ACYP2	hdpi__FLI1	FLI1 (directAnnotation).
ACYP2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ACYP2	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
ACYP2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
ACYP2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
ACYP2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ACYP2	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
ACYP2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
ACYP2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
ACYP2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
ACYP2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
ACYP2	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
ACYP2	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
ACYP2	hdpi__ETV4	ETV4 (directAnnotation).
ACYP2	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
ACYP2	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
ACYP2	jaspar__MA1708.1	ETV7 (directAnnotation).
ACYP2	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
ACYP2	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
ACYP2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ACYP2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ACYP2	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
ACYP2	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
ACYP2	cisbp__M02645	ETS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ACYP2	"Formic acid"	DB01942	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."