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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ACVR2B

Summary for ACVR2B

Gene information	Gene symbol	ACVR2B
	Ensembl ID	ENSG00000114739
	Entrez ID	93
	Gene name	activin A receptor type 2B
	Synonyms	ActR-IIB
	Gene type	protein_coding
	UniProtAcc	Q13705

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Dataset with differentially expressed gene: ACVR2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.257397	0.00e+00

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Expression of ACVR2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ACVR2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ACVR2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ACVR2B	hsa-miR-6867-5p	100	NM_001106
ACVR2B	hsa-miR-5011-5p	100	NM_001106
ACVR2B	hsa-miR-190a-3p	99.897	NM_001106
ACVR2B	hsa-miR-12119	99.8742	NM_001106
ACVR2B	hsa-miR-4262	99.5356	NM_001106
ACVR2B	hsa-miR-374a-5p	99.1832	NM_001106
ACVR2B	hsa-miR-374b-5p	99.0511	NM_001106
ACVR2B	hsa-miR-181c-5p	98.957	NM_001106
ACVR2B	hsa-miR-181b-5p	98.7278	NM_001106
ACVR2B	hsa-miR-181d-5p	98.7278	NM_001106
ACVR2B	hsa-miR-181a-5p	98.7278	NM_001106
ACVR2B	hsa-miR-548x-3p	98.5523	NM_001106
ACVR2B	hsa-miR-548aj-3p	98.5523	NM_001106
ACVR2B	hsa-miR-140-3p	98.3941	NM_001106
ACVR2B	hsa-miR-4795-3p	97.8501	NM_001106
ACVR2B	hsa-miR-548j-3p	97.7735	NM_001106
ACVR2B	hsa-miR-548aq-3p	97.7735	NM_001106
ACVR2B	hsa-miR-548ah-3p	97.7735	NM_001106
ACVR2B	hsa-miR-548ae-3p	97.7735	NM_001106
ACVR2B	hsa-miR-548am-3p	97.7735	NM_001106
ACVR2B	hsa-miR-98-3p	97.6945	NM_001106
ACVR2B	hsa-miR-607	97.6313	NM_001106
ACVR2B	hsa-let-7f-1-3p	97.278	NM_001106
ACVR2B	hsa-let-7b-3p	97.278	NM_001106
ACVR2B	hsa-let-7a-3p	97.278	NM_001106
ACVR2B	hsa-miR-548ar-3p	97.0903	NM_001106
ACVR2B	hsa-miR-7162-3p	96.9609	NM_001106
ACVR2B	hsa-miR-548a-3p	96.8479	NM_001106
ACVR2B	hsa-miR-548bc	96.8017	NM_001106
ACVR2B	hsa-miR-548e-3p	96.8017	NM_001106
ACVR2B	hsa-miR-548f-3p	96.8017	NM_001106
ACVR2B	hsa-miR-548az-3p	96.8017	NM_001106
ACVR2B	hsa-miR-181a-2-3p	96.7948	NM_001106
ACVR2B	hsa-miR-133a-5p	96.6802	NM_001106
ACVR2B	hsa-miR-4303	96.5042	NM_001106
ACVR2B	hsa-miR-101-3p	96.4283	NM_001106
ACVR2B	hsa-miR-519e-5p	96.2534	NM_001106
ACVR2B	hsa-miR-1277-5p	95.8085	NM_001106
ACVR2B	hsa-miR-515-5p	95.3978	NM_001106
ACVR2B	hsa-miR-4755-5p	95.388	NM_001106
ACVR2B	hsa-miR-5006-3p	95.388	NM_001106
ACVR2B	hsa-miR-300	95.3202	NM_001106
ACVR2B	hsa-miR-381-3p	95.3202	NM_001106
ACVR2B	hsa-miR-335-3p	95.3115	NM_001106
ACVR2B	hsa-miR-103a-3p	95.1938	NM_001106
ACVR2B	hsa-miR-107	95.1938	NM_001106
ACVR2B	hsa-miR-3148	94.7902	NM_001106
ACVR2B	hsa-miR-619-3p	94.7727	NM_001106
ACVR2B	hsa-miR-4652-3p	94.3103	NM_001106
ACVR2B	hsa-miR-5582-3p	94.3075	NM_001106

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Motifs and transcription factors (TFs) regulating ACVR2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ACVR2B	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ACVR2B	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."