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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ACSL3

Summary for ACSL3

Gene information	Gene symbol	ACSL3
	Ensembl ID	ENSG00000123983
	Entrez ID	2181
	Gene name	acyl-CoA synthetase long chain family member 3
	Synonyms	ACS3\|FACL3\|PRO2194
	Gene type	protein_coding
	UniProtAcc	O95573

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Dataset with differentially expressed gene: ACSL3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.434713	2.54e-34
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.411536	3.97e-22
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.314618	1.72e-15
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.602225	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.654014	0.00e+00

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Expression of ACSL3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ACSL3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ACSL3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ACSL3	hsa-miR-7159-5p	99.5257	NM_004457
ACSL3	hsa-miR-4672	98.2232	NM_004457
ACSL3	hsa-miR-153-5p	97.7806	NM_004457
ACSL3	hsa-miR-3065-5p	94.2076	NM_004457
ACSL3	hsa-miR-3140-3p	93.4143	NM_004457
ACSL3	hsa-miR-4803	93.0899	NM_004457
ACSL3	hsa-miR-223-3p	92.2785	NM_004457
ACSL3	hsa-miR-5689	92.0444	NM_004457
ACSL3	hsa-miR-663a	91.7235	NM_004457
ACSL3	hsa-miR-1908-5p	91.7235	NM_004457
ACSL3	hsa-miR-10396b-5p	91.7235	NM_004457
ACSL3	hsa-miR-421	91.5506	NM_004457
ACSL3	hsa-miR-6787-5p	91.1606	NM_004457
ACSL3	hsa-miR-6876-3p	91.1292	NM_004457
ACSL3	hsa-miR-3685	90.2822	NM_004457
ACSL3	hsa-miR-384	90.2202	NM_004457
ACSL3	hsa-miR-626	90.2127	NM_004457
ACSL3	hsa-miR-300	90.1264	NM_004457
ACSL3	hsa-miR-381-3p	90.1264	NM_004457
ACSL3	hsa-miR-548aj-3p	89.94	NM_004457
ACSL3	hsa-miR-548x-3p	89.94	NM_004457
ACSL3	hsa-miR-6833-3p	89.1768	NM_004457
ACSL3	hsa-miR-4666a-3p	88.7809	NM_004457
ACSL3	hsa-miR-524-5p	88.3232	NM_004457
ACSL3	hsa-miR-520d-5p	88.3232	NM_004457
ACSL3	hsa-miR-4680-3p	88.2749	NM_004457
ACSL3	hsa-miR-1297	88.0373	NM_004457
ACSL3	hsa-miR-5700	88.0024	NM_004457
ACSL3	hsa-miR-105-5p	87.8619	NM_004457
ACSL3	hsa-miR-7853-5p	87.8619	NM_004457
ACSL3	hsa-miR-548aq-3p	87.5472	NM_004457
ACSL3	hsa-miR-548am-3p	87.5472	NM_004457
ACSL3	hsa-miR-548ah-3p	87.5472	NM_004457
ACSL3	hsa-miR-548j-3p	87.5472	NM_004457
ACSL3	hsa-miR-548ae-3p	87.5472	NM_004457
ACSL3	hsa-miR-26a-5p	87.3153	NM_004457
ACSL3	hsa-miR-26b-5p	87.3153	NM_004457
ACSL3	hsa-miR-590-3p	86.8675	NM_004457
ACSL3	hsa-miR-3943	86.7779	NM_004457
ACSL3	hsa-miR-4465	86.6016	NM_004457
ACSL3	hsa-miR-4724-5p	86.3879	NM_004457
ACSL3	hsa-miR-6871-5p	85.5129	NM_004457
ACSL3	hsa-miR-4768-5p	85.1733	NM_004457
ACSL3	hsa-miR-580-5p	85.1183	NM_004457
ACSL3	hsa-miR-4524a-3p	83.4153	NM_004457
ACSL3	hsa-miR-1185-2-3p	83.3941	NM_004457
ACSL3	hsa-miR-1185-1-3p	83.3941	NM_004457
ACSL3	hsa-let-7f-2-3p	83.3941	NM_004457
ACSL3	hsa-miR-18a-5p	83.0657	NM_004457
ACSL3	hsa-miR-18b-5p	83.0657	NM_004457

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Motifs and transcription factors (TFs) regulating ACSL3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ACSL3	transfac_pro__M06035	ZNF749 (directAnnotation).
ACSL3	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
ACSL3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ACSL3	transfac_pro__M01253	CNOT3 (directAnnotation).
ACSL3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ACSL3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ACSL3	transfac_pro__M04916	TAF1 (directAnnotation).
ACSL3	metacluster_111.5	E4F1; E4F1 (directAnnotation).
ACSL3	metacluster_135.11	NR2C2 (directAnnotation).
ACSL3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ACSL3	tfdimers__MD00038	TFAP2C (directAnnotation).
ACSL3	metacluster_7.13	ZFX (directAnnotation).
ACSL3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ACSL3	cisbp__M00968	MTF2 (directAnnotation).
ACSL3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ACSL3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ACSL3	cisbp__M00341	PAX6 (directAnnotation).
ACSL3	metacluster_198.3	ZFP64 (directAnnotation).
ACSL3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ACSL3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ACSL3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ACSL3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ACSL3	cisbp__M00788	ZFY (inferredBy_Orthology).
ACSL3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ACSL3	metacluster_175.1	ZNF283 (directAnnotation).
ACSL3	hdpi__ZNF304	ZNF304 (directAnnotation).
ACSL3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ACSL3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ACSL3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ACSL3	transfac_pro__M01199	TRIM28 (directAnnotation).
ACSL3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ACSL3	metacluster_151.2	ZNF23 (directAnnotation).
ACSL3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ACSL3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ACSL3	transfac_pro__M03806	ZBTB7C (directAnnotation).
ACSL3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ACSL3	jaspar__MA0502.2	NFYB (directAnnotation).
ACSL3	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ACSL3	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
ACSL3	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ACSL3	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ACSL3	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ACSL3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ACSL3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ACSL3	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
ACSL3	transfac_pro__M05432	ZSCAN18 (directAnnotation).
ACSL3	transfac_pro__M06104	ZNF16 (directAnnotation).
ACSL3	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ACSL3	cisbp__M01725	SREBF2 (inferredBy_Orthology).
ACSL3	transfac_pro__M06601	ZNF501 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."