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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ACLY

Summary for ACLY

Gene information	Gene symbol	ACLY
	Ensembl ID	ENSG00000131473
	Entrez ID	47
	Gene name	ATP citrate lyase
	Synonyms	ACL\|ATPCL\|CLATP
	Gene type	protein_coding
	UniProtAcc	P53396

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Dataset with differentially expressed gene: ACLY

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.453047	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.373166	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.278015	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.378627	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.355988	0.00e+00

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Expression of ACLY in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ACLY

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ACLY

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ACLY	hsa-miR-655-3p	95.7375	NM_001096
ACLY	hsa-miR-374c-5p	95.7375	NM_001096
ACLY	hsa-miR-22-5p	94.3861	NM_001096
ACLY	hsa-miR-297	93.4523	NM_001096
ACLY	hsa-miR-5683	92.8991	NM_001096
ACLY	hsa-miR-6844	92.7618	NM_001096
ACLY	hsa-miR-7159-3p	91.5445	NM_001096
ACLY	hsa-miR-548c-3p	91.3769	NM_001096
ACLY	hsa-miR-3911	90.9517	NM_001096
ACLY	hsa-miR-8056	90.4184	NM_001096
ACLY	hsa-miR-369-3p	89.8183	NM_001096
ACLY	hsa-miR-509-5p	89.4159	NM_001096
ACLY	hsa-miR-509-3-5p	89.4159	NM_001096
ACLY	hsa-miR-147a	87.946	NM_001096
ACLY	hsa-miR-2115-5p	87.2265	NM_001096
ACLY	hsa-miR-10525-3p	87.0436	NM_001096
ACLY	hsa-miR-194-3p	86.6429	NM_001096
ACLY	hsa-miR-567	86.5075	NM_001096
ACLY	hsa-miR-4664-5p	86.485	NM_001096
ACLY	hsa-miR-4418	85.9989	NM_001096
ACLY	hsa-miR-1275	85.5157	NM_001096
ACLY	hsa-miR-342-5p	85.1685	NM_001096
ACLY	hsa-miR-4740-5p	84.8462	NM_001096
ACLY	hsa-miR-4797-5p	82.393	NM_001096
ACLY	hsa-miR-3691-5p	81.1985	NM_001096
ACLY	hsa-miR-4428	80.8674	NM_001096
ACLY	hsa-miR-758-3p	80.7932	NM_001096
ACLY	hsa-miR-4719	80.3406	NM_001096

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Motifs and transcription factors (TFs) regulating ACLY

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ACLY	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ACLY	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
ACLY	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ACLY	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
ACLY	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
ACLY	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
ACLY	transfac_pro__M06249	ZNF616 (directAnnotation).
ACLY	taipale_tf_pairs__GCM1_ETV7_NTNNNGGCGGAAGNNNTTCCNNN_CAP_repr	ETV7; GCM1 (directAnnotation).
ACLY	metacluster_102.2	ZBED1 (directAnnotation).
ACLY	metacluster_141.4	GLIS2 (directAnnotation).
ACLY	transfac_pro__M06135	ZNF28 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ACLY	"Bempedoic acid"	DB11936	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."