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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ACACA

Summary for ACACA

Gene information	Gene symbol	ACACA
	Ensembl ID	ENSG00000275176
	Entrez ID	31
	Gene name	acetyl-CoA carboxylase alpha
	Synonyms	ACAC\|Acac1\|ACACalpha\|ACC\|ACC-alpha\|ACC1\|ACCA\|ACCalpha\|hACC1
	Gene type	protein_coding
	UniProtAcc	Q13085

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Dataset with differentially expressed gene: ACACA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.357841	0.00e+00

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Expression of ACACA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ACACA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ACACA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ACACA	hsa-miR-3065-5p	97.3138	NM_198834
ACACA	hsa-miR-7159-5p	95.4912	NM_198834
ACACA	hsa-miR-1825	91.1294	NM_198834
ACACA	hsa-miR-660-3p	90.9764	NM_198834
ACACA	hsa-miR-299-3p	87.1506	NM_198834
ACACA	hsa-miR-4700-5p	86.3181	NM_198834
ACACA	hsa-miR-4687-3p	84.1022	NM_198834
ACACA	hsa-miR-4654	83.7801	NM_198834
ACACA	hsa-miR-1283	83.3658	NM_198834
ACACA	hsa-miR-8089	83.209	NM_198834
ACACA	hsa-miR-7151-5p	83.0141	NM_198834
ACACA	hsa-miR-4317	82.9843	NM_198834
ACACA	hsa-miR-3667-5p	81.3705	NM_198834
ACACA	hsa-miR-548ao-3p	81.3705	NM_198834
ACACA	hsa-miR-5193	80.7566	NM_198834
ACACA	hsa-miR-6747-3p	80.1353	NM_198834

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Motifs and transcription factors (TFs) regulating ACACA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ACACA	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
ACACA	transfac_pro__M02089	E2F3 (directAnnotation).
ACACA	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ACACA	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ACACA	transfac_pro__M04817	ZBTB33 (directAnnotation).
ACACA	metacluster_143.13	ZBTB7A (directAnnotation).
ACACA	tfdimers__MD00483	ZBTB14 (directAnnotation).
ACACA	cisbp__M07938	E2F1 (directAnnotation).
ACACA	cisbp__M00968	MTF2 (directAnnotation).
ACACA	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ACACA	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ACACA	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ACACA	jaspar__MA1122.1	TFDP1 (directAnnotation).
ACACA	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ACACA	"Biotin"	DB00121	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."