Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABTB2

Summary for ABTB2

Gene information	Gene symbol	ABTB2
	Ensembl ID	ENSG00000166016
	Entrez ID	25841
	Gene name	ankyrin repeat and BTB domain containing 2
	Synonyms	ABTB2A\|BTBD22\|DKFZP586C1619
	Gene type	protein_coding
	UniProtAcc	Q8N961

Top

Dataset with differentially expressed gene: ABTB2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.562765	1.10e-02

Top

Expression of ABTB2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ABTB2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ABTB2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABTB2	hsa-miR-2053	99.5738	NM_145804
ABTB2	hsa-miR-582-5p	98.7121	NM_145804
ABTB2	hsa-miR-569	98.058	NM_145804
ABTB2	hsa-let-7g-3p	97.6164	NM_145804
ABTB2	hsa-let-7a-2-3p	97.6164	NM_145804
ABTB2	hsa-miR-493-5p	97.5422	NM_145804
ABTB2	hsa-miR-5701	96.3122	NM_145804
ABTB2	hsa-miR-3120-3p	94.5031	NM_145804
ABTB2	hsa-miR-548ap-3p	94.4412	NM_145804
ABTB2	hsa-miR-548t-3p	94.4412	NM_145804
ABTB2	hsa-miR-548aa	94.4412	NM_145804
ABTB2	hsa-miR-4703-5p	93.773	NM_145804
ABTB2	hsa-miR-3942-5p	93.773	NM_145804
ABTB2	hsa-miR-5008-5p	93.7573	NM_145804
ABTB2	hsa-miR-3659	92.579	NM_145804
ABTB2	hsa-miR-6504-3p	92.3441	NM_145804
ABTB2	hsa-miR-10399-5p	92.3441	NM_145804
ABTB2	hsa-let-7c-3p	91.4737	NM_145804
ABTB2	hsa-miR-637	90.1706	NM_145804
ABTB2	hsa-miR-95-5p	89.6904	NM_145804
ABTB2	hsa-miR-3121-3p	89.5285	NM_145804
ABTB2	hsa-miR-4262	88.0258	NM_145804
ABTB2	hsa-miR-6846-5p	86.8708	NM_145804
ABTB2	hsa-miR-6848-5p	86.8708	NM_145804
ABTB2	hsa-miR-4501	86.3205	NM_145804
ABTB2	hsa-miR-181c-5p	85.7024	NM_145804
ABTB2	hsa-miR-181b-5p	85.7024	NM_145804
ABTB2	hsa-miR-181d-5p	85.7024	NM_145804
ABTB2	hsa-miR-181a-5p	85.7024	NM_145804
ABTB2	hsa-miR-6844	85.5362	NM_145804
ABTB2	hsa-miR-6089	85.1563	NM_145804
ABTB2	hsa-miR-6838-3p	83.5493	NM_145804
ABTB2	hsa-miR-338-5p	82.4084	NM_145804
ABTB2	hsa-miR-3180-5p	81.7809	NM_145804
ABTB2	hsa-miR-7152-3p	81.7754	NM_145804
ABTB2	hsa-miR-6838-5p	81.616	NM_145804
ABTB2	hsa-miR-548as-3p	81.5342	NM_145804
ABTB2	hsa-miR-154-3p	81.5309	NM_145804
ABTB2	hsa-miR-487a-3p	81.5309	NM_145804
ABTB2	hsa-miR-3163	80.793	NM_145804

Page: 1

Top

Motifs and transcription factors (TFs) regulating ABTB2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."