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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABR

Summary for ABR

Gene information	Gene symbol	ABR
	Ensembl ID	ENSG00000276016
	Entrez ID	29
	Gene name	ABR activator of RhoGEF and GTPase
	Synonyms	MDB
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ABR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.43114	3.96e-04
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.579245	0.00e+00

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Expression of ABR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ABR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABR	hsa-miR-4731-5p	99.1392	NM_001092
ABR	hsa-miR-2113	94.9135	NM_001092
ABR	hsa-miR-19b-3p	94.586	NM_001092
ABR	hsa-miR-19a-3p	94.586	NM_001092
ABR	hsa-miR-3667-3p	93.8681	NM_001092
ABR	hsa-miR-5589-5p	92.4468	NM_001092
ABR	hsa-miR-4505	91.6155	NM_001092
ABR	hsa-miR-5010-3p	91.6051	NM_001092
ABR	hsa-miR-5787	91.5478	NM_001092
ABR	hsa-miR-6830-3p	91.3751	NM_001092
ABR	hsa-miR-6865-5p	90.9031	NM_001092
ABR	hsa-miR-6815-5p	90.9031	NM_001092
ABR	hsa-miR-766-5p	90.5118	NM_001092
ABR	hsa-miR-5195-3p	89.7777	NM_001092
ABR	hsa-miR-145-5p	89.7777	NM_001092
ABR	hsa-miR-4283	89.74	NM_001092
ABR	hsa-miR-4514	89.3485	NM_001092
ABR	hsa-miR-4692	87.9716	NM_001092
ABR	hsa-miR-299-5p	87.0012	NM_001092
ABR	hsa-miR-320e	86.0702	NM_001092
ABR	hsa-miR-34a-5p	84.7329	NM_001092
ABR	hsa-miR-449a	84.7329	NM_001092
ABR	hsa-miR-6079	84.6167	NM_001092
ABR	hsa-miR-3059-5p	84.353	NM_001092
ABR	hsa-miR-3613-3p	84.1873	NM_001092
ABR	hsa-miR-449b-5p	84.0822	NM_001092
ABR	hsa-miR-34c-5p	84.0822	NM_001092
ABR	hsa-miR-6868-5p	83.2252	NM_001092
ABR	hsa-miR-4521	82.8055	NM_001092
ABR	hsa-miR-485-5p	82.4251	NM_001092
ABR	hsa-miR-6884-5p	82.4251	NM_001092
ABR	hsa-miR-374a-5p	81.3167	NM_001092
ABR	hsa-miR-4492	80.7216	NM_001092
ABR	hsa-miR-6510-5p	80.6641	NM_001092
ABR	hsa-miR-504-3p	80.2071	NM_001092

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Motifs and transcription factors (TFs) regulating ABR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABR	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ABR	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ABR	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ABR	metacluster_151.2	ZNF23 (directAnnotation).
ABR	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ABR	transfac_pro__M05479	ZNF580 (directAnnotation).
ABR	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ABR	hdpi__ETV4	ETV4 (directAnnotation).
ABR	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ABR	jaspar__MA0079.5	SP1 (directAnnotation).
ABR	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ABR	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ABR	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ABR	transfac_pro__M07436	WT1 (directAnnotation).
ABR	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ABR	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ABR	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ABR	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."