Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABLIM3

Summary for ABLIM3

Gene information	Gene symbol	ABLIM3
	Ensembl ID	ENSG00000173210
	Entrez ID	22885
	Gene name	actin binding LIM protein family member 3
	Synonyms	KIAA0843
	Gene type	protein_coding
	UniProtAcc	O94929

Top

Dataset with differentially expressed gene: ABLIM3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.53231	8.39e-07
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.35413	1.08e-14

Top

Expression of ABLIM3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ABLIM3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ABLIM3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABLIM3	hsa-miR-548s	97.6873	NM_001301028
ABLIM3	hsa-miR-4311	96.5522	NM_001301015
ABLIM3	hsa-miR-6715b-5p	96.4457	NM_001301015
ABLIM3	hsa-miR-4269	96.4457	NM_001301015
ABLIM3	hsa-miR-3926	96.1347	NM_001301028
ABLIM3	hsa-miR-6845-5p	95.5834	NM_001301015
ABLIM3	hsa-miR-6762-5p	95.5834	NM_001301015
ABLIM3	hsa-miR-4761-5p	95.4292	NM_001301028
ABLIM3	hsa-miR-296-3p	91.0435	NM_001301028
ABLIM3	hsa-miR-4695-3p	91.0035	NM_001301028
ABLIM3	hsa-miR-5695	89.0346	NM_001301015
ABLIM3	hsa-miR-448	88.0422	NM_001301015
ABLIM3	hsa-miR-7110-5p	87.4214	NM_001301015
ABLIM3	hsa-miR-6842-5p	87.4214	NM_001301015
ABLIM3	hsa-miR-3657	87.0816	NM_001301015
ABLIM3	hsa-miR-222-5p	86.0516	NM_001301015
ABLIM3	hsa-miR-6752-5p	85.301	NM_001301015
ABLIM3	hsa-miR-4801	84.7148	NM_001301015
ABLIM3	hsa-miR-6891-5p	83.3623	NM_001301015
ABLIM3	hsa-miR-1236-3p	82.8753	NM_001301015
ABLIM3	hsa-miR-12118	81.402	NM_001301015
ABLIM3	hsa-miR-3173-3p	81.402	NM_001301015
ABLIM3	hsa-miR-6837-5p	80.5834	NM_001301015
ABLIM3	hsa-miR-4685-5p	80.5834	NM_001301015
ABLIM3	hsa-miR-4731-3p	80.3143	NM_001301015

Page: 1

Top

Motifs and transcription factors (TFs) regulating ABLIM3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABLIM3	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ABLIM3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ABLIM3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ABLIM3	transfac_pro__M03876	ZBTB33 (directAnnotation).
ABLIM3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ABLIM3	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
ABLIM3	cisbp__M07938	E2F1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."