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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABI1

Summary for ABI1

Gene information	Gene symbol	ABI1
	Ensembl ID	ENSG00000136754
	Entrez ID	10006
	Gene name	abl interactor 1
	Synonyms	ABI-1\|E3B1\|SSH3BP1
	Gene type	protein_coding
	UniProtAcc	Q8IZP0

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Dataset with differentially expressed gene: ABI1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.276646	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.264601	5.61e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.30746	2.24e-44
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.29791	8.69e-40
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.252566	3.54e-03

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Expression of ABI1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABI1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ABI1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABI1	hsa-miR-4282	99.4267	NM_001178124
ABI1	hsa-miR-4801	98.9558	NM_001012750
ABI1	hsa-miR-4672	98.4525	NM_001012750
ABI1	hsa-miR-3941	98.4525	NM_001012750
ABI1	hsa-miR-466	97.9954	NM_001012750
ABI1	hsa-miR-4731-3p	97.9119	NM_001012750
ABI1	hsa-miR-889-3p	96.9998	NM_001178124
ABI1	hsa-let-7a-3p	96.1816	NM_001012750
ABI1	hsa-let-7b-3p	96.1816	NM_001012750
ABI1	hsa-let-7f-1-3p	96.1816	NM_001012750
ABI1	hsa-miR-98-3p	96.1816	NM_001012750
ABI1	hsa-miR-144-3p	95.9453	NM_001012750
ABI1	hsa-miR-513c-3p	95.1749	NM_001012750
ABI1	hsa-miR-513a-3p	95.1749	NM_001012750
ABI1	hsa-miR-3606-3p	94.9815	NM_001012750
ABI1	hsa-miR-5700	94.44	NM_001012750
ABI1	hsa-miR-4719	94.1266	NM_001012750
ABI1	hsa-miR-580-3p	93.8361	NM_001012750
ABI1	hsa-miR-10527-5p	93.7011	NM_001012750
ABI1	hsa-miR-6857-3p	93.5789	NM_001012750
ABI1	hsa-miR-6131	92.9061	NM_001012750
ABI1	hsa-miR-190a-3p	92.8571	NM_001012750
ABI1	hsa-miR-8069	92.8	NM_001178124
ABI1	hsa-miR-138-1-3p	92.1221	NM_001178124
ABI1	hsa-miR-548f-5p	91.965	NM_001178124
ABI1	hsa-miR-300	90.816	NM_001012750
ABI1	hsa-miR-381-3p	90.816	NM_001012750
ABI1	hsa-miR-548aj-5p	90.6563	NM_001178124
ABI1	hsa-miR-548x-5p	90.6563	NM_001178124
ABI1	hsa-miR-548g-5p	90.6563	NM_001178124
ABI1	hsa-miR-4703-5p	90.5787	NM_001012750
ABI1	hsa-miR-3688-3p	90.3164	NM_001178124
ABI1	hsa-miR-3942-5p	89.4372	NM_001012750
ABI1	hsa-miR-520h	89.2452	NM_001012750
ABI1	hsa-miR-520g-3p	89.2452	NM_001012750
ABI1	hsa-miR-5582-3p	89.207	NM_001178124
ABI1	hsa-miR-4666a-3p	89.0432	NM_001012750
ABI1	hsa-miR-4478	88.9517	NM_001012750
ABI1	hsa-miR-491-3p	88.6438	NM_001012750
ABI1	hsa-miR-5187-3p	88.4627	NM_001178124
ABI1	hsa-miR-380-3p	87.7512	NM_001178124
ABI1	hsa-miR-544a	87.5723	NM_001178124
ABI1	hsa-miR-4439	87.5046	NM_001012750
ABI1	hsa-miR-3136-5p	87.5046	NM_001012750
ABI1	hsa-miR-3924	87.2957	NM_001178124
ABI1	hsa-miR-548at-5p	86.9996	NM_001178124
ABI1	hsa-miR-3148	86.9137	NM_001178124
ABI1	hsa-miR-3929	86.7375	NM_001012750
ABI1	hsa-miR-5588-3p	86.4597	NM_001178124
ABI1	hsa-miR-4452	86.4361	NM_001012750

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Motifs and transcription factors (TFs) regulating ABI1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABI1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ABI1	cisbp__M00788	ZFY (inferredBy_Orthology).
ABI1	metacluster_7.13	ZFX (directAnnotation).
ABI1	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
ABI1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ABI1	hdpi__HIP2	UBE2K (directAnnotation).
ABI1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ABI1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ABI1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ABI1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ABI1	transfac_pro__M02898	SMAD3 (directAnnotation).
ABI1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ABI1	metacluster_191.5	SPDEF (inferredBy_Orthology).
ABI1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ABI1	hdpi__TIMELESS	TIMELESS (directAnnotation).
ABI1	transfac_pro__M04893	TAF1 (directAnnotation).
ABI1	cisbp__M00249	WT1 (directAnnotation).
ABI1	transfac_pro__M00430	E2F1 (directAnnotation).
ABI1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ABI1	hdpi__ZNF304	ZNF304 (directAnnotation).
ABI1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
ABI1	transfac_pro__M00938	E2F1 (directAnnotation).
ABI1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ABI1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ABI1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ABI1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ABI1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ABI1	jaspar__MA1721.1	ZNF93 (directAnnotation).
ABI1	metacluster_151.2	ZNF23 (directAnnotation).
ABI1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ABI1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ABI1	transfac_pro__M01199	TRIM28 (directAnnotation).
ABI1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ABI1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ABI1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ABI1	transfac_pro__M01253	CNOT3 (directAnnotation).
ABI1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ABI1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ABI1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ABI1	cisbp__M00968	MTF2 (directAnnotation).
ABI1	jaspar__MA0748.2	YY2 (directAnnotation).
ABI1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ABI1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ABI1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ABI1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ABI1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ABI1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ABI1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ABI1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
ABI1	transfac_pro__M07310	SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."