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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABHD4

Summary for ABHD4

Gene information	Gene symbol	ABHD4
	Ensembl ID	ENSG00000100439
	Entrez ID	63874
	Gene name	abhydrolase domain containing 4, N-acyl phospholipase B
	Synonyms	FLJ12816
	Gene type	protein_coding
	UniProtAcc	Q8TB40

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Dataset with differentially expressed gene: ABHD4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.262092	3.83e-07
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.253407	2.28e-13
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.747959	0.00e+00

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Expression of ABHD4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABHD4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ABHD4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABHD4	hsa-miR-4477a	95.5997	NM_022060
ABHD4	hsa-miR-4733-3p	94.1639	NM_022060
ABHD4	hsa-miR-3675-5p	93.9826	NM_022060
ABHD4	hsa-miR-1207-5p	93.7542	NM_022060
ABHD4	hsa-miR-7106-5p	92.4149	NM_022060
ABHD4	hsa-miR-4763-3p	92.1958	NM_022060
ABHD4	hsa-miR-4710	91.1964	NM_022060
ABHD4	hsa-miR-3179	89.1075	NM_022060
ABHD4	hsa-miR-4283	88.7436	NM_022060
ABHD4	hsa-miR-3922-5p	86.9276	NM_022060
ABHD4	hsa-miR-6799-5p	86.5047	NM_022060
ABHD4	hsa-miR-6809-5p	85.9845	NM_022060
ABHD4	hsa-miR-4299	85.9228	NM_022060
ABHD4	hsa-miR-877-3p	85.8011	NM_022060
ABHD4	hsa-miR-5001-3p	82.6869	NM_022060
ABHD4	hsa-miR-4489	81.7081	NM_022060
ABHD4	hsa-miR-185-3p	80.4818	NM_022060
ABHD4	hsa-miR-498-3p	80.4363	NM_022060
ABHD4	hsa-miR-4721	80.1626	NM_022060

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Motifs and transcription factors (TFs) regulating ABHD4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABHD4	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ABHD4	transfac_pro__M00652	NRF1 (directAnnotation).
ABHD4	hdpi__TP73	TP73 (directAnnotation).
ABHD4	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
ABHD4	jaspar__MA1708.1	ETV7 (directAnnotation).
ABHD4	cisbp__M02645	ETS1 (directAnnotation).
ABHD4	metacluster_22.15	BACH1 (directAnnotation).
ABHD4	metacluster_22.14	BACH1 (inferredBy_Orthology).
ABHD4	transfac_pro__M06135	ZNF28 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."