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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABHD2

Summary for ABHD2

Gene information	Gene symbol	ABHD2
	Ensembl ID	ENSG00000140526
	Entrez ID	11057
	Gene name	abhydrolase domain containing 2, acylglycerol lipase
	Synonyms	LABH2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ABHD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.563558	2.14e-25
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.281561	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-1.14082	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.398417	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.505032	3.88e-39
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.815465	0.00e+00

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Expression of ABHD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABHD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ABHD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABHD2	hsa-miR-520h	96.2431	NM_152924
ABHD2	hsa-miR-520g-3p	96.2431	NM_152924
ABHD2	hsa-miR-4531	95.5165	NM_152924
ABHD2	hsa-miR-33b-5p	95.2692	NM_007011
ABHD2	hsa-miR-33a-5p	95.2692	NM_007011
ABHD2	hsa-miR-4314	95.2486	NM_007011
ABHD2	hsa-miR-5584-5p	95.1867	NM_007011
ABHD2	hsa-miR-6124	95.0279	NM_152924
ABHD2	hsa-miR-4646-5p	92.8139	NM_007011
ABHD2	hsa-miR-153-5p	92.5121	NM_007011
ABHD2	hsa-miR-12128	91.7723	NM_152924
ABHD2	hsa-miR-211-3p	91.4134	NM_152924
ABHD2	hsa-miR-4441	91.2444	NM_152924
ABHD2	hsa-miR-548x-3p	90.6359	NM_152924
ABHD2	hsa-miR-548aj-3p	90.6359	NM_152924
ABHD2	hsa-miR-589-3p	90.1778	NM_152924
ABHD2	hsa-miR-15b-5p	89.9738	NM_007011
ABHD2	hsa-miR-15a-5p	89.9738	NM_007011
ABHD2	hsa-miR-16-5p	89.9738	NM_007011
ABHD2	hsa-miR-195-5p	89.9738	NM_007011
ABHD2	hsa-miR-6838-5p	89.7589	NM_007011
ABHD2	hsa-miR-548j-3p	89.5899	NM_152924
ABHD2	hsa-miR-548ae-3p	89.5899	NM_152924
ABHD2	hsa-miR-548aq-3p	89.5899	NM_152924
ABHD2	hsa-miR-3192-5p	89.5863	NM_007011
ABHD2	hsa-miR-497-5p	88.9536	NM_007011
ABHD2	hsa-miR-424-5p	88.9536	NM_007011
ABHD2	hsa-miR-4270	88.6478	NM_152924
ABHD2	hsa-miR-6127	88.2935	NM_152924
ABHD2	hsa-miR-3654	86.9563	NM_152924
ABHD2	hsa-miR-6754-5p	86.3727	NM_152924
ABHD2	hsa-miR-6876-5p	86.2133	NM_152924
ABHD2	hsa-miR-15b-3p	85.9781	NM_152924
ABHD2	hsa-miR-548am-3p	85.7729	NM_152924
ABHD2	hsa-miR-548ah-3p	85.7729	NM_152924
ABHD2	hsa-miR-619-5p	85.5807	NM_007011
ABHD2	hsa-miR-3180-5p	84.676	NM_007011
ABHD2	hsa-miR-6878-5p	84.4684	NM_152924
ABHD2	hsa-miR-204-3p	83.4797	NM_007011
ABHD2	hsa-miR-4291	83.4625	NM_007011
ABHD2	hsa-miR-520a-5p	83.462	NM_007011
ABHD2	hsa-miR-525-5p	83.462	NM_007011
ABHD2	hsa-miR-548m	83.3557	NM_007011
ABHD2	hsa-miR-20a-5p	83.3527	NM_007011
ABHD2	hsa-miR-106b-5p	83.3527	NM_007011
ABHD2	hsa-miR-6506-5p	83.1323	NM_007011
ABHD2	hsa-miR-4533	83.0657	NM_152924
ABHD2	hsa-miR-6828-5p	82.5734	NM_007011
ABHD2	hsa-miR-3942-3p	82.1333	NM_007011
ABHD2	hsa-miR-4476	81.786	NM_152924

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Motifs and transcription factors (TFs) regulating ABHD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABHD2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ABHD2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ABHD2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ABHD2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ABHD2	cisbp__M00341	PAX6 (directAnnotation).
ABHD2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ABHD2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ABHD2	cisbp__M00788	ZFY (inferredBy_Orthology).
ABHD2	metacluster_175.1	ZNF283 (directAnnotation).
ABHD2	hdpi__ZNF304	ZNF304 (directAnnotation).
ABHD2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ABHD2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ABHD2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ABHD2	transfac_pro__M01199	TRIM28 (directAnnotation).
ABHD2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ABHD2	transfac_pro__M03806	ZBTB7C (directAnnotation).
ABHD2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ABHD2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ABHD2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ABHD2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ABHD2	metacluster_3.10	KLF2; KLF4 (directAnnotation).
ABHD2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ABHD2	jaspar__MA1721.1	ZNF93 (directAnnotation).
ABHD2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ABHD2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ABHD2	tfdimers__MD00151	CHURC1 (directAnnotation).
ABHD2	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
ABHD2	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
ABHD2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ABHD2	transfac_pro__M01973	PLAG1 (directAnnotation).
ABHD2	transfac_pro__M01303	SP1 (directAnnotation).
ABHD2	transfac_public__M00491	PATZ1 (directAnnotation).
ABHD2	transfac_pro__M07397	ZNF148 (directAnnotation).
ABHD2	jaspar__MA0079.5	SP1 (directAnnotation).
ABHD2	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
ABHD2	transfac_pro__M01253	CNOT3 (directAnnotation).
ABHD2	transfac_pro__M04817	ZBTB33 (directAnnotation).
ABHD2	transfac_pro__M02089	E2F3 (directAnnotation).
ABHD2	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
ABHD2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."