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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABHD17C

Summary for ABHD17C

Gene information	Gene symbol	ABHD17C
	Ensembl ID	ENSG00000136379
	Entrez ID	58489
	Gene name	abhydrolase domain containing 17C, depalmitoylase
	Synonyms	FAM108C1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ABHD17C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.03453	4.91e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.522426	0.00e+00

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Expression of ABHD17C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABHD17C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ABHD17C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABHD17C	hsa-miR-5195-3p	99.9213	NM_021214
ABHD17C	hsa-miR-145-5p	99.9157	NM_021214
ABHD17C	hsa-miR-101-3p	99.7145	NM_021214
ABHD17C	hsa-miR-9985	97.8195	NM_021214
ABHD17C	hsa-miR-27b-3p	97.8195	NM_021214
ABHD17C	hsa-miR-27a-3p	97.8195	NM_021214
ABHD17C	hsa-miR-513a-5p	95.791	NM_021214
ABHD17C	hsa-miR-4491	95.6377	NM_021214
ABHD17C	hsa-miR-4657	95.6377	NM_021214
ABHD17C	hsa-miR-5093	94.49	NM_021214
ABHD17C	hsa-miR-4649-3p	93.5474	NM_021214
ABHD17C	hsa-miR-330-3p	92.9552	NM_021214
ABHD17C	hsa-miR-3148	91.1308	NM_021214
ABHD17C	hsa-miR-4778-3p	90.908	NM_021214
ABHD17C	hsa-miR-548p	90.7348	NM_021214
ABHD17C	hsa-miR-3606-5p	90.5782	NM_021214
ABHD17C	hsa-miR-144-3p	90.4746	NM_021214
ABHD17C	hsa-miR-19b-3p	90.0895	NM_021214
ABHD17C	hsa-miR-19a-3p	90.0895	NM_021214
ABHD17C	hsa-miR-3658	89.6804	NM_021214
ABHD17C	hsa-miR-6833-5p	89.3891	NM_021214
ABHD17C	hsa-miR-199b-5p	88.3129	NM_021214
ABHD17C	hsa-miR-199a-5p	88.3129	NM_021214
ABHD17C	hsa-miR-3188	87.488	NM_021214
ABHD17C	hsa-miR-216a-3p	87.0444	NM_021214
ABHD17C	hsa-miR-128-3p	87.0444	NM_021214
ABHD17C	hsa-let-7a-2-3p	86.437	NM_021214
ABHD17C	hsa-let-7g-3p	86.437	NM_021214
ABHD17C	hsa-miR-3163	85.7793	NM_021214
ABHD17C	hsa-miR-3681-3p	84.0408	NM_021214
ABHD17C	hsa-miR-98-5p	83.8519	NM_021214
ABHD17C	hsa-miR-4500	83.8519	NM_021214
ABHD17C	hsa-miR-4293	83.056	NM_021214
ABHD17C	hsa-miR-4422	82.9298	NM_021214
ABHD17C	hsa-miR-17-3p	82.5309	NM_021214
ABHD17C	hsa-miR-6818-5p	82.4776	NM_021214
ABHD17C	hsa-miR-3134	82.0716	NM_021214
ABHD17C	hsa-miR-582-5p	82.0146	NM_021214
ABHD17C	hsa-miR-6507-5p	81.8404	NM_021214
ABHD17C	hsa-miR-3119	81.1532	NM_021214
ABHD17C	hsa-miR-4282	80.2402	NM_021214

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Motifs and transcription factors (TFs) regulating ABHD17C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABHD17C	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ABHD17C	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ABHD17C	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ABHD17C	transfac_pro__M04617	ZBTB7A (directAnnotation).
ABHD17C	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ABHD17C	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
ABHD17C	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ABHD17C	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ABHD17C	transfac_pro__M07387	ZBTB7A (directAnnotation).
ABHD17C	transfac_pro__M07436	WT1 (directAnnotation).
ABHD17C	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ABHD17C	transfac_pro__M00716	ZBTB14 (directAnnotation).
ABHD17C	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ABHD17C	hdpi__HIP2	UBE2K (directAnnotation).
ABHD17C	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ABHD17C	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ABHD17C	transfac_pro__M04893	TAF1 (directAnnotation).
ABHD17C	transfac_pro__M03876	ZBTB33 (directAnnotation).
ABHD17C	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ABHD17C	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ABHD17C	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ABHD17C	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ABHD17C	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ABHD17C	metacluster_135.11	NR2C2 (directAnnotation).
ABHD17C	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ABHD17C	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ABHD17C	metacluster_7.13	ZFX (directAnnotation).
ABHD17C	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ABHD17C	cisbp__M00968	MTF2 (directAnnotation).
ABHD17C	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ABHD17C	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ABHD17C	cisbp__M00341	PAX6 (directAnnotation).
ABHD17C	metacluster_198.3	ZFP64 (directAnnotation).
ABHD17C	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ABHD17C	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ABHD17C	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ABHD17C	cisbp__M00788	ZFY (inferredBy_Orthology).
ABHD17C	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ABHD17C	metacluster_175.1	ZNF283 (directAnnotation).
ABHD17C	hdpi__ZNF304	ZNF304 (directAnnotation).
ABHD17C	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ABHD17C	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ABHD17C	transfac_pro__M01199	TRIM28 (directAnnotation).
ABHD17C	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ABHD17C	metacluster_151.2	ZNF23 (directAnnotation).
ABHD17C	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ABHD17C	transfac_pro__M03806	ZBTB7C (directAnnotation).
ABHD17C	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."