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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ABCC9

Summary for ABCC9

Gene information	Gene symbol	ABCC9
	Ensembl ID	ENSG00000069431
	Entrez ID	10060
	Gene name	ATP binding cassette subfamily C member 9
	Synonyms	CMD1O\|SUR2
	Gene type	protein_coding
	UniProtAcc	O60706

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Dataset with differentially expressed gene: ABCC9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.518183	0.00e+00

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Expression of ABCC9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABCC9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ABCC9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABCC9	hsa-miR-6832-5p	99.5842	NM_020297
ABCC9	hsa-miR-3123	99.4657	NM_020297
ABCC9	hsa-miR-190a-3p	97.344	NM_020297
ABCC9	hsa-miR-3121-3p	95.7711	NM_020297
ABCC9	hsa-miR-5011-5p	94.6864	NM_020297
ABCC9	hsa-miR-6074	92.8744	NM_020297
ABCC9	hsa-miR-3925-5p	92.8356	NM_020297
ABCC9	hsa-miR-4282	92.788	NM_020297
ABCC9	hsa-miR-4463	92.4073	NM_020297
ABCC9	hsa-miR-4666a-5p	91.217	NM_020297
ABCC9	hsa-miR-651-3p	90.1561	NM_020297
ABCC9	hsa-miR-6809-3p	89.6641	NM_020297
ABCC9	hsa-miR-10527-5p	89.3319	NM_020297
ABCC9	hsa-miR-30b-5p	89.1071	NM_020297
ABCC9	hsa-miR-30d-5p	89.1071	NM_020297
ABCC9	hsa-miR-30e-5p	89.1071	NM_020297
ABCC9	hsa-miR-30a-5p	89.1071	NM_020297
ABCC9	hsa-miR-30c-5p	89.1071	NM_020297
ABCC9	hsa-miR-5584-5p	88.8867	NM_020297
ABCC9	hsa-miR-548l	88.1998	NM_020297
ABCC9	hsa-miR-5589-3p	87.5357	NM_020297
ABCC9	hsa-miR-6833-3p	87.2135	NM_020297
ABCC9	hsa-miR-647	86.9982	NM_020297
ABCC9	hsa-miR-3942-5p	86.2927	NM_020297
ABCC9	hsa-miR-380-3p	86.0748	NM_020297
ABCC9	hsa-miR-4703-5p	85.6369	NM_020297
ABCC9	hsa-miR-2113	85.2067	NM_020297
ABCC9	hsa-miR-4696	84.8124	NM_020297
ABCC9	hsa-miR-1200	84.1981	NM_020297
ABCC9	hsa-miR-4423-3p	84.0604	NM_020297
ABCC9	hsa-miR-3686	83.959	NM_020297
ABCC9	hsa-miR-4768-5p	83.4499	NM_020297
ABCC9	hsa-miR-3163	83.2976	NM_020297
ABCC9	hsa-miR-4782-5p	83.008	NM_020297
ABCC9	hsa-miR-5706	83.008	NM_020297
ABCC9	hsa-miR-3674	82.1086	NM_020297
ABCC9	hsa-miR-103a-1-5p	81.986	NM_020297
ABCC9	hsa-miR-103a-2-5p	81.986	NM_020297
ABCC9	hsa-miR-29a-5p	81.4724	NM_020297
ABCC9	hsa-miR-5007-3p	80.7183	NM_020297

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Motifs and transcription factors (TFs) regulating ABCC9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABCC9	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ABCC9	"ATP"	DB00171	small molecule
ABCC9	"Glyburide"	DB01016	small molecule
ABCC9	"Nicorandil"	DB09220	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."