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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ABCC2

Summary for ABCC2

Gene information	Gene symbol	ABCC2
	Ensembl ID	ENSG00000023839
	Entrez ID	1244
	Gene name	ATP binding cassette subfamily C member 2
	Synonyms	CMOAT\|cMRP\|DJS\|MRP2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ABCC2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-3.56205	1.54e-03
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.578501	0.00e+00

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Expression of ABCC2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABCC2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
ABCC2	Irregularity in Drug Uptake and Drug Efflux

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MicroRNAs (miRNA) regulating ABCC2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABCC2	hsa-miR-4742-3p	94.719	NM_000392
ABCC2	hsa-miR-4778-5p	93.7715	NM_000392
ABCC2	hsa-miR-4330	92.3706	NM_000392
ABCC2	hsa-miR-630	88.4728	NM_000392
ABCC2	hsa-miR-603	88.2673	NM_000392
ABCC2	hsa-miR-297	85.3271	NM_000392
ABCC2	hsa-miR-501-5p	83.4427	NM_000392
ABCC2	hsa-miR-224-5p	82.9803	NM_000392
ABCC2	hsa-miR-548h-3p	81.8457	NM_000392
ABCC2	hsa-miR-548d-3p	81.8457	NM_000392
ABCC2	hsa-miR-548z	81.8457	NM_000392
ABCC2	hsa-miR-548ac	81.8457	NM_000392
ABCC2	hsa-miR-548bb-3p	81.8457	NM_000392
ABCC2	hsa-miR-548ar-3p	80.4026	NM_000392
ABCC2	hsa-miR-7112-3p	80.1924	NM_000392
ABCC2	hsa-miR-490-3p	80.0138	NM_000392

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Motifs and transcription factors (TFs) regulating ABCC2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ABCC2	"ATP"	DB00171	small molecule
ABCC2	"Azvudine"	DB16407	small molecule
ABCC2	"Sulfinpyrazone"	DB01138	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."