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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABCB9

Summary for ABCB9

Gene information	Gene symbol	ABCB9
	Ensembl ID	ENSG00000150967
	Entrez ID	23457
	Gene name	ATP binding cassette subfamily B member 9
	Synonyms	EST122234
	Gene type	protein_coding
	UniProtAcc	Q9NP78

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Dataset with differentially expressed gene: ABCB9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.37028	4.16e-11
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.783408	0.00e+00

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Expression of ABCB9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABCB9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
ABCB9	Irregularity in Drug Uptake and Drug Efflux

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MicroRNAs (miRNA) regulating ABCB9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABCB9	hsa-miR-24-3p	94.338	NM_019624
ABCB9	hsa-miR-128-3p	89.977	NM_001243013
ABCB9	hsa-miR-216a-3p	89.977	NM_001243013
ABCB9	hsa-miR-27b-3p	88.0177	NM_001243013
ABCB9	hsa-miR-27a-3p	88.0177	NM_001243013
ABCB9	hsa-miR-9985	88.0177	NM_001243013
ABCB9	hsa-miR-299-3p	87.197	NM_203444
ABCB9	hsa-miR-3681-3p	86.084	NM_001243013
ABCB9	hsa-miR-4500	85.4737	NM_001243013
ABCB9	hsa-miR-150-5p	85.4303	NM_019624
ABCB9	hsa-miR-3194-5p	85.2579	NM_001243013
ABCB9	hsa-let-7b-5p	83.2753	NM_001243013
ABCB9	hsa-let-7e-5p	83.2753	NM_001243013
ABCB9	hsa-let-7f-5p	83.2753	NM_001243013
ABCB9	hsa-miR-4458	83.2753	NM_001243013
ABCB9	hsa-let-7i-5p	83.2753	NM_001243013
ABCB9	hsa-let-7c-5p	83.2753	NM_001243013
ABCB9	hsa-let-7a-5p	83.2753	NM_001243013
ABCB9	hsa-let-7g-5p	83.2753	NM_001243013
ABCB9	hsa-let-7d-5p	83.2753	NM_001243013
ABCB9	hsa-miR-98-5p	83.2753	NM_001243013
ABCB9	hsa-miR-4667-5p	82.6494	NM_203444
ABCB9	hsa-miR-8089	82.6494	NM_203444
ABCB9	hsa-miR-4700-5p	82.6494	NM_203444

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Motifs and transcription factors (TFs) regulating ABCB9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABCB9	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
ABCB9	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
ABCB9	metacluster_196.7	POLR3A (directAnnotation).
ABCB9	jaspar__MA1125.1	ZNF384 (directAnnotation).
ABCB9	taipale_tf_pairs__GCM1_HOXB13_RTGCGGGTAATAAAN_CAP	GCM1; HOXB13 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."