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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABCB10

Summary for ABCB10

Gene information	Gene symbol	ABCB10
	Ensembl ID	ENSG00000135776
	Entrez ID	23456
	Gene name	ATP binding cassette subfamily B member 10
	Synonyms	EST20237\|M-ABC2\|MTABC2
	Gene type	protein_coding
	UniProtAcc	Q9NRK6

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Dataset with differentially expressed gene: ABCB10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.444043	1.22e-21
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.53689	0.00e+00

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Expression of ABCB10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABCB10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ABCB10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABCB10	hsa-miR-3163	99.8613	NM_012089
ABCB10	hsa-miR-3148	95.6055	NM_012089
ABCB10	hsa-miR-3133	95.4282	NM_012089
ABCB10	hsa-miR-4714-5p	95.3547	NM_012089
ABCB10	hsa-miR-664a-3p	93.8981	NM_012089
ABCB10	hsa-miR-7154-5p	92.8928	NM_012089
ABCB10	hsa-miR-590-3p	92.8275	NM_012089
ABCB10	hsa-miR-3672	92.7503	NM_012089
ABCB10	hsa-miR-183-5p	92.1043	NM_012089
ABCB10	hsa-miR-6864-3p	91.2865	NM_012089
ABCB10	hsa-miR-603	89.0613	NM_012089
ABCB10	hsa-miR-3941	88.6552	NM_012089
ABCB10	hsa-miR-548x-5p	87.2256	NM_012089
ABCB10	hsa-miR-548aj-5p	87.2256	NM_012089
ABCB10	hsa-miR-548g-5p	87.2256	NM_012089
ABCB10	hsa-miR-548f-5p	87.2256	NM_012089
ABCB10	hsa-miR-19b-2-5p	86.2679	NM_012089
ABCB10	hsa-miR-19a-5p	86.2679	NM_012089
ABCB10	hsa-miR-19b-1-5p	86.2679	NM_012089
ABCB10	hsa-miR-361-5p	85.4055	NM_012089
ABCB10	hsa-miR-194-5p	85.117	NM_012089
ABCB10	hsa-miR-4427	85.0795	NM_012089
ABCB10	hsa-miR-5581-3p	84.9071	NM_012089
ABCB10	hsa-miR-12136	84.5878	NM_012089
ABCB10	hsa-miR-6766-3p	84.5371	NM_012089
ABCB10	hsa-miR-4782-3p	84.5371	NM_012089
ABCB10	hsa-miR-219a-5p	84.5371	NM_012089
ABCB10	hsa-miR-1266-3p	84.0986	NM_012089
ABCB10	hsa-miR-484	84.0288	NM_012089
ABCB10	hsa-miR-5582-3p	83.4669	NM_012089
ABCB10	hsa-miR-670-3p	82.8082	NM_012089
ABCB10	hsa-miR-3977	82.0499	NM_012089
ABCB10	hsa-miR-1267	81.5417	NM_012089
ABCB10	hsa-miR-3922-3p	81.4456	NM_012089
ABCB10	hsa-miR-3176	81.4456	NM_012089
ABCB10	hsa-miR-607	81.2392	NM_012089
ABCB10	hsa-miR-216b-3p	80.9626	NM_012089
ABCB10	hsa-miR-3155a	80.3855	NM_012089
ABCB10	hsa-miR-3155b	80.3855	NM_012089

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Motifs and transcription factors (TFs) regulating ABCB10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABCB10	transfac_pro__M00652	NRF1 (directAnnotation).
ABCB10	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ABCB10	metacluster_101.3	MYB (directAnnotation).
ABCB10	transfac_pro__M05893	ZNF676 (directAnnotation).
ABCB10	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."