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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ABAT

Summary for ABAT

Gene information	Gene symbol	ABAT
	Ensembl ID	ENSG00000183044
	Entrez ID	18
	Gene name	4-aminobutyrate aminotransferase
	Synonyms	GABA-T\|GABAT
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ABAT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.306313	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.409608	2.67e-24

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Expression of ABAT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABAT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ABAT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABAT	hsa-miR-7850-5p	92.0054	NM_000663
ABAT	hsa-miR-183-5p	91.7387	NM_001127448
ABAT	hsa-miR-545-5p	90.8404	NM_001127448
ABAT	hsa-miR-3180-5p	88.8389	NM_000663
ABAT	hsa-miR-6837-5p	86.6058	NM_001127448
ABAT	hsa-miR-374a-5p	86.3581	NM_001127448
ABAT	hsa-miR-6768-5p	85.8955	NM_000663
ABAT	hsa-miR-374b-5p	85.0026	NM_001127448
ABAT	hsa-miR-3686	83.4118	NM_000663
ABAT	hsa-miR-6507-5p	83.2435	NM_000663
ABAT	hsa-miR-4520-3p	82.1945	NM_001127448
ABAT	hsa-miR-6831-3p	81.9601	NM_001127448
ABAT	hsa-miR-4685-5p	81.3338	NM_001127448
ABAT	hsa-miR-3646	81.1608	NM_001127448

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Motifs and transcription factors (TFs) regulating ABAT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABAT	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
ABAT	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ABAT	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ABAT	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ABAT	"(4e)-4-Aminohex-4-Enoic Acid"	DB01699	small molecule
ABAT	"4-Amino Hexanoic Acid"	DB04235	small molecule
ABAT	"Alanine"	DB00160	small molecule
ABAT	"Glutamic acid"	DB00142	small molecule
ABAT	"Phenelzine"	DB00780	small molecule
ABAT	"Pyridoxal phosphate"	DB00114	small molecule
ABAT	"Pyruvic acid"	DB00119	small molecule
ABAT	"Vigabatrin"	DB01080	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."