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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: AADAT

Summary for AADAT

Gene information	Gene symbol	AADAT
	Ensembl ID	ENSG00000109576
	Entrez ID	51166
	Gene name	aminoadipate aminotransferase
	Synonyms	KAT2\|KATII\|KYAT2
	Gene type	protein_coding
	UniProtAcc	Q8N5Z0

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Dataset with differentially expressed gene: AADAT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.64245	0.00e+00

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Expression of AADAT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AADAT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AADAT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AADAT	hsa-miR-507	93.3264	NM_001286682
AADAT	hsa-miR-3915	92.0046	NM_001286682
AADAT	hsa-miR-450b-5p	91.4176	NM_001286682
AADAT	hsa-miR-4502	91.183	NM_001286682
AADAT	hsa-miR-557	89.9542	NM_001286682
AADAT	hsa-miR-616-5p	86.8855	NM_001286682
AADAT	hsa-miR-3682-5p	86.5398	NM_001286682
AADAT	hsa-miR-3680-3p	85.8365	NM_001286682
AADAT	hsa-miR-22-5p	85.7682	NM_001286682
AADAT	hsa-miR-5579-5p	85.7255	NM_001286682
AADAT	hsa-miR-548n	85.5368	NM_001286682
AADAT	hsa-miR-130a-5p	82.6228	NM_001286682
AADAT	hsa-miR-6727-3p	82.3763	NM_001286682
AADAT	hsa-miR-371b-5p	81.6489	NM_001286682
AADAT	hsa-miR-373-5p	81.6489	NM_001286682
AADAT	hsa-miR-4722-3p	80.3249	NM_001286682

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Motifs and transcription factors (TFs) regulating AADAT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AADAT	cisbp__M07938	E2F1 (directAnnotation).
AADAT	cisbp__M00968	MTF2 (directAnnotation).
AADAT	jaspar__MA1122.1	TFDP1 (directAnnotation).
AADAT	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
AADAT	"Glutamic acid"	DB00142	small molecule
AADAT	"Pyridoxal phosphate"	DB00114	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."