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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SLC6A2

Summary for SLC6A2

Gene information	Gene symbol	SLC6A2
	Ensembl ID	ENSG00000103546
	Entrez ID	6530
	Gene name	solute carrier family 6 member 2
	Synonyms	NAT1\|NET\|NET1\|SLC6A5
	Gene type	protein_coding
	UniProtAcc	P23975

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Dataset with differentially expressed gene: SLC6A2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.905963	0.00e+00

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Expression of SLC6A2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC6A2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC6A2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC6A2	hsa-miR-6887-3p	94.7542	NM_001043
SLC6A2	hsa-miR-198	92.8479	NM_001172504
SLC6A2	hsa-miR-4668-3p	89.7132	NM_001172504
SLC6A2	hsa-miR-9-5p	89.2543	NM_001172504
SLC6A2	hsa-miR-6777-3p	89.2269	NM_001043
SLC6A2	hsa-miR-4251	89.1685	NM_001172504
SLC6A2	hsa-miR-4733-5p	88.7494	NM_001043
SLC6A2	hsa-miR-6833-3p	88.6066	NM_001172504
SLC6A2	hsa-miR-6817-3p	87.7827	NM_001043
SLC6A2	hsa-miR-4435	87.3153	NM_001043
SLC6A2	hsa-miR-600	86.0727	NM_001172504
SLC6A2	hsa-miR-580-3p	85.503	NM_001172504
SLC6A2	hsa-miR-664b-3p	85.2956	NM_001043
SLC6A2	hsa-miR-579-3p	85.2956	NM_001043
SLC6A2	hsa-miR-4323	85.2429	NM_001172504
SLC6A2	hsa-miR-6797-3p	84.913	NM_001172504
SLC6A2	hsa-miR-3200-5p	84.5183	NM_001172504
SLC6A2	hsa-miR-4768-5p	84.172	NM_001172504
SLC6A2	hsa-miR-6076	83.3081	NM_001172504
SLC6A2	hsa-miR-7-1-3p	83.0559	NM_001172504
SLC6A2	hsa-miR-7-2-3p	83.0559	NM_001172504
SLC6A2	hsa-miR-12124	82.418	NM_001172504
SLC6A2	hsa-miR-4786-3p	80.0369	NM_001172504

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Motifs and transcription factors (TFs) regulating SLC6A2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SLC6A2	"Orphenadrine"	DB01173	small molecule
SLC6A2	"Paroxetine"	DB00715	small molecule
SLC6A2	"Phendimetrazine"	DB01579	small molecule
SLC6A2	"Phenmetrazine"	DB00830	small molecule
SLC6A2	"Phentermine"	DB00191	small molecule
SLC6A2	"Protriptyline"	DB00344	small molecule
SLC6A2	"Pseudoephedrine"	DB00852	small molecule
SLC6A2	"Reboxetine"	DB00234	small molecule
SLC6A2	"Serdexmethylphenidate"	DB16629	small molecule
SLC6A2	"Sertraline"	DB01104	small molecule
SLC6A2	"Sibutramine"	DB01105	small molecule
SLC6A2	"Solriamfetol"	DB14754	small molecule
SLC6A2	"Tapentadol"	DB06204	small molecule
SLC6A2	"Tesofensine"	DB06156	small molecule
SLC6A2	"Tramadol"	DB00193	small molecule
SLC6A2	"Trimipramine"	DB00726	small molecule
SLC6A2	"Trodusquemine"	DB06333	small molecule
SLC6A2	"Venlafaxine"	DB00285	small molecule
SLC6A2	"Viloxazine"	DB09185	small molecule
SLC6A2	"Vortioxetine"	DB09068	small molecule
SLC6A2	"XEN-2174"	DB05012	small molecule
SLC6A2	"Zotepine"	DB09225	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."