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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CDK2

Summary for CDK2

Gene information	Gene symbol	CDK2
	Ensembl ID	ENSG00000123374
	Entrez ID	1017
	Gene name	cyclin dependent kinase 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CDK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.365484	4.88e-33
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.335076	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.363174	0.00e+00

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Expression of CDK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CDK2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CDK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDK2	hsa-miR-6847-5p	93.6819	NM_001290230
CDK2	hsa-miR-1248	91.4495	NM_001290230
CDK2	hsa-miR-3659	88.6013	NM_001290230
CDK2	hsa-miR-153-5p	88.241	NM_001290230
CDK2	hsa-miR-597-3p	87.7707	NM_001290230
CDK2	hsa-miR-520d-5p	87.659	NM_001290230
CDK2	hsa-miR-524-5p	87.659	NM_001290230
CDK2	hsa-miR-1250-3p	87.4359	NM_001290230
CDK2	hsa-miR-7976	86.3261	NM_001290230
CDK2	hsa-miR-519a-3p	86.0216	NM_001290230
CDK2	hsa-miR-519b-3p	86.0216	NM_001290230
CDK2	hsa-miR-519c-3p	86.0216	NM_001290230
CDK2	hsa-miR-6779-3p	81.4409	NM_001290230
CDK2	hsa-miR-6757-3p	80.5023	NM_001290230
CDK2	hsa-miR-5582-5p	80.4899	NM_001290230
CDK2	hsa-miR-6868-3p	80.1918	NM_001290230
CDK2	hsa-miR-3154	80.0503	NM_001290230

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Motifs and transcription factors (TFs) regulating CDK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CDK2	"4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine"	DB08178	small molecule
CDK2	"4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine"	DB08182	small molecule
CDK2	"4-(5-Bromo-2-Oxo-2h-Indol-3-Ylazo)-Benzenesulfonamide"	DB02973	small molecule
CDK2	"4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE"	DB08241	small molecule
CDK2	"4-(acetylamino)-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide"	DB08136	small molecule
CDK2	"4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE"	DB07687	small molecule
CDK2	"4-Methyl-5-[(2Z)-2-{[4-(4-morpholinyl)phenyl]imino}-2,5-dihydro-4-pyrimidinyl]-1,3-thiazol-2-amine"	DB08219	small molecule
CDK2	"4-[(4-Imidazo[1,2-a]Pyridin-3-Ylpyrimidin-2-Yl)Amino]Benzenesulfonamide"	DB02197	small molecule
CDK2	"4-[(5-ISOPROPYL-1,3-THIAZOL-2-YL)AMINO]BENZENESULFONAMIDE"	DB08673	small molecule
CDK2	"4-[(6-Amino-4-Pyrimidinyl)Amino]Benzenesulfonamide"	DB03307	small molecule
CDK2	"4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide"	DB08134	small molecule
CDK2	"4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE"	DB06844	small molecule
CDK2	"4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline"	DB03365	small molecule
CDK2	"4-[4-(4-Methyl-2-Methylamino-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol"	DB04407	small molecule
CDK2	"4-[5-(Trans-4-Aminocyclohexylamino)-3-Isopropylpyrazolo[1,5-a]Pyrimidin-7-Ylamino]-N,N-Dimethylbenz	DB01888	small molecule
CDK2	"4-{5-[(1Z)-1-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)ETHYL]-2-FURYL}BENZENESULFONAMIDE"	DB07540	small molecule
CDK2	"4-{5-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE"	DB07531	small molecule
CDK2	"4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDE"	DB07533	small molecule
CDK2	"4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESUL	DB07538	small molecule
CDK2	"4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE"	DB07534	small molecule
CDK2	"4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID"	DB07539	small molecule
CDK2	"4-{[(2,6-difluorophenyl)carbonyl]amino}-N-[(3S)-piperidin-3-yl]-1H-pyrazole-3-carboxamide"	DB08141	small molecule
CDK2	"4-{[(2-Oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide"	DB08125	small molecule
CDK2	"4-{[4-(1-CYCLOPROPYL-2-METHYL-1H-IMIDAZOL-5-YL)PYRIMIDIN-2-YL]AMINO}-N-METHYLBENZENESULFONAMIDE"	DB07791	small molecule
CDK2	"4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDE"	DB08572	small molecule
CDK2	"4-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE"	DB07686	small molecule
CDK2	"4-{[5-(CYCLOHEXYLMETHOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE"	DB07685	small molecule
CDK2	"4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE"	DB07688	small molecule
CDK2	"5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)-3-thiocyanatopyrazolo[1,5-a]pyrimidin-7-amine"	DB07065	small molecule
CDK2	"5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine"	DB08531	small molecule
CDK2	"5-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine"	DB08534	small molecule
CDK2	"5-Bromoindirubin"	DB07493	small molecule
CDK2	"5-chloro-7-[(1-methylethyl)amino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile"	DB08139	small molecule
CDK2	"5-hydroxynaphthalene-1-sulfonamide"	DB08132	small molecule
CDK2	"5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE"	DB07163	small molecule
CDK2	"5-[(4-AMINOCYCLOHEXYL)AMINO]-7-(PROPAN-2-YLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE"	DB08140	small molecule
CDK2	"5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE	DB07471	small molecule
CDK2	"6-(2-fluorophenyl)-N-(pyridin-3-ylmethyl)imidazo[1,2-a]pyrazin-8-amine"	DB08532	small molecule
CDK2	"6-(3,4-DIHYDROXYBENZYL)-3-ETHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE"	DB07606	small molecule
CDK2	"6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE"	DB07612	small molecule
CDK2	"6-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINE"	DB08247	small molecule
CDK2	"6-BROMO-13-THIA-2,4,8,12,19-PENTAAZATRICYCLO[12.3.1.1~3,7~]NONADECA-1(18),3(19),4,6,14,16-HEXAENE 1	DB08441	small molecule
CDK2	"6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE"	DB07203	small molecule
CDK2	"6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE"	DB08233	small molecule
CDK2	"6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE"	DB08312	small molecule
CDK2	"6-O-Cyclohexylmethyl Guanine"	DB02407	small molecule
CDK2	"Alvocidib"	DB03496	small molecule
CDK2	"AT-7519"	DB08142	small molecule
CDK2	"Bosutinib"	DB06616	small molecule
CDK2	"CAN-508"	DB07731	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."