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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene (This gene does not contain this module)

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: RPS4Y1

Summary for RPS4Y1

Gene informationGene symbol

RPS4Y1

Ensembl ID

ENSG00000129824

Entrez ID

6192

Gene nameribosomal protein S4 Y-linked 1
SynonymsMGC119100|MGC5070|RPS4Y|S4
Gene typeprotein_coding
UniProtAcc

P22090


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Dataset with differentially expressed gene: RPS4Y1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE138267

CDXTumor tissueLung cancerSmall cell lung cancer (SCLC)ChemotherapyNANAMalignant cells0.9860630.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)postCD8+ T cells-0.5551550.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)postNK cells-0.5959150.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)postCD4+ T cells-1.090110.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)postProgenitors-1.72181.39e-22

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)preCD4+ T cells-1.482350.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)preMono/Macro-0.7291310.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)precDCs-0.8167169.00e-42

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)preCD8+ T cells-0.8379170.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)preNK cells-0.3315110.00e+00

GSE164237

patientsPeripheral blood mononuclear cellsMelanomaAdvanced stages of melanoma ImmunotherapypembrolizumabpostCD8+ T cells0.373610.00e+00

GSE164237

patientsPeripheral blood mononuclear cellsMelanomaAdvanced stages of melanoma ImmunotherapypembrolizumabpreCD8+ T cells0.5163750.00e+00

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postB cells0.2724161.05e-02

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)postMono/Macro-0.4225110.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)postNK cells-0.4677580.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preNK cells-1.127270.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preCD8+ T cells-0.7505020.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preMono/Macro-0.3544450.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preCD4+ T cells-1.784570.00e+00

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postB cells-0.4406664.89e-05

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMalignant cells0.3025182.06e-16

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreNK cells-0.3150374.57e-38

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreCD4+ T cells-0.2514963.22e-07

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreCD8+ T cells-0.6337220.00e+00

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMalignant cells0.6657020.00e+00

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMono/Macro-0.3306341.47e-27

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostcDCs1.008081.27e-05

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostB cells0.9562449.08e-03

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostCD4+ T cells0.9757524.95e-09

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostNK cells0.7816990.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostCD8+ T cells0.8436350.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepostMono/Macro0.5986890.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreMono/Macro0.6240750.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreCD8+ T cells1.131420.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasoneprecDCs0.8548021.45e-06

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreMalignant cells0.6272340.00e+00

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostMalignant cells0.5969360.00e+00

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostCD8+ T cells0.3980365.99e-10

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostNK cells0.6373132.69e-18

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostpDCs0.8294034.23e-03

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostCD4+ T cells0.4938033.15e-36

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostcDCs1.052430.00e+00

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpostErythrocytes0.4841222.58e-02

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpreCD8+ T cells0.570978.15e-25

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpreNK cells0.4228029.12e-08

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpreMalignant cells0.370450.00e+00

GSE162117

patientsPeripheral blood mononuclear cellsAcute myeloid leukemiaTefractory acute myeloid leukemia (AML)Targeted therapyficlatuzumabpreCD4+ T cells0.8038130.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD8+ T cells0.2884670.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreMalignant cells0.3567750.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreB cells-1.603411.23e-10

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostMalignant cells-0.5155064.55e-38

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostCD4+ T cells-0.6844980.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostMono/Macro-0.8687550.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostCD8+ T cells-0.9929450.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreMono/Macro-0.9548295.07e-08

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreCD4+ T cells-1.291230.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreCD8+ T cells-1.112720.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreMalignant cells-0.6718580.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreNK cells-1.069822.26e-10

GSE152469

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibNAMalignant cells0.6078650.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostCD8+ T cells0.9316260.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostNK cells0.5678745.49e-28

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostCD4+ T cells1.041063.28e-17

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostB cells0.3312716.04e-03

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostMono/Macro0.6928570.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostMalignant cells0.5220390.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreB cells0.3343747.14e-14

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-1.421020.00e+00

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Expression of RPS4Y1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to RPS4Y1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RPS4Y1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

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Motifs and transcription factors (TFs) regulating RPS4Y1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
RPS4Y1hdpi__ZNF695ZNF695 (directAnnotation).
RPS4Y1transfac_pro__M02269FEV (directAnnotation).
RPS4Y1transfac_pro__M05786ZNF605 (directAnnotation).
RPS4Y1taipale_tf_pairs__GCM1_MAX_RTGCGGGNNNNNNNCACGTGN_CAP_reprGCM1; MAX (directAnnotation).
RPS4Y1kznf__ZNF736_Imbeault2017_OM_RCADEZNF736 (directAnnotation).
RPS4Y1transfac_pro__M06492ZNF770 (inferredBy_Orthology).
RPS4Y1metacluster_181.2GLIS1; GLIS3 (directAnnotation).
RPS4Y1swissregulon__mm__Pbx1PBX1 (inferredBy_Orthology).
RPS4Y1transfac_pro__M06344ZNF530 (directAnnotation).
RPS4Y1transfac_pro__M05853ZNF548 (directAnnotation).
RPS4Y1transfac_pro__M06409ZNF329 (directAnnotation).
RPS4Y1kznf__GTF3A_Schmitges2016_RCADEGTF3A (directAnnotation).
RPS4Y1kznf__ZNF10_Imbeault2017_RP_RCADEZNF10 (directAnnotation).
RPS4Y1taipale_tf_pairs__FLI1_DLX2_RSCGGAARYAATTA_CAPDLX2; FLI1 (directAnnotation).
RPS4Y1transfac_pro__M04810USF2 (directAnnotation).
RPS4Y1taipale__YY2_DBD_NNCCGCCATNW_reprYY2 (directAnnotation).
RPS4Y1taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_reprETV2; SOX15 (directAnnotation).
RPS4Y1dbtfbs__ZKSCAN8_representative_N1ZKSCAN8 (directAnnotation).
RPS4Y1metacluster_166.5ERG; ETV2; FLI1 (directAnnotation).
RPS4Y1taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAPELK3; FOXO1 (directAnnotation).
RPS4Y1taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_methCDX2 (directAnnotation).
RPS4Y1metacluster_183.3EHF; ELF3; FLI1; SPIB (directAnnotation). EHF; EHF; ELF2; ELF3; ELF4; ELF5; ERG; ERG; ETV3; ETV6; FLI1; SPI1; SPI1 (inferredBy_Orthology).
RPS4Y1metacluster_183.4ETS1 (inferredBy_Orthology).
RPS4Y1metacluster_138.2ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RPS4Y1transfac_pro__M04937TCF12 (directAnnotation).
RPS4Y1tfdimers__MD00210CDX2; HMBOX1 (directAnnotation).
RPS4Y1taipale_tf_pairs__ALX4_TBX21_RGGTGYTAATWR_CAPALX4; TBX21 (directAnnotation).
RPS4Y1transfac_pro__M05402BCL6B (directAnnotation).
RPS4Y1taipale_tf_pairs__TEAD4_EOMES_NGYGNNAMATWCYNNTMRCRCN_CAP_reprEOMES; TEAD4 (directAnnotation).
RPS4Y1transfac_pro__M04849RELA (directAnnotation).
RPS4Y1transfac_pro__M05615ZFP2 (inferredBy_Orthology).
RPS4Y1tfdimers__MD00595SREBF1; SREBF2; TBP (directAnnotation).
RPS4Y1hdpi__ETS1ETS1 (directAnnotation).
RPS4Y1metacluster_177.7ZBTB18; ZBTB18; ZBTB18; ZBTB42 (directAnnotation).
RPS4Y1tfdimers__MD00031MYB; ZEB1 (directAnnotation).
RPS4Y1metacluster_52.11ZNF184 (directAnnotation).
RPS4Y1transfac_pro__M06759ZNF646 (directAnnotation).
RPS4Y1transfac_pro__M06566ZNF845 (directAnnotation).
RPS4Y1metacluster_64.9NR1I2 (directAnnotation).
RPS4Y1metacluster_64.8NR1I2 (directAnnotation).
RPS4Y1taipale_tf_pairs__ETV2_SOX15_RSCGGAWNNNNNNNACAATRN_CAP_reprETV2; SOX15 (directAnnotation).
RPS4Y1transfac_pro__M06862ZNF671 (directAnnotation).
RPS4Y1transfac_pro__M04868EP300 (directAnnotation).
RPS4Y1metacluster_191.5SPDEF (inferredBy_Orthology).
RPS4Y1transfac_pro__M06408ZSCAN30 (directAnnotation).
RPS4Y1transfac_pro__M01153NR1I2; RXRA (directAnnotation).
RPS4Y1taipale_tf_pairs__HOXD12_ELK3_RSCGGAAGTAATAAAN_CAPELK3; HOXD12 (directAnnotation).
RPS4Y1metacluster_156.3DBP; DBP; DBP; DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; TEF; TEF; TEF; TEF; TEF (directAnnotation). DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFILZ; NFILZ; TEF; TEF; TEF; TEF (inferredBy_Orthology).
RPS4Y1transfac_pro__M06383ZNF629 (inferredBy_Orthology).
RPS4Y1hdpi__RAXRAX (directAnnotation).
Page: 1 2 3 4 5 6 7 8 9

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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."