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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FKBP5

Summary for FKBP5

Gene information	Gene symbol	FKBP5
	Ensembl ID	ENSG00000096060
	Entrez ID	2289
	Gene name	FKBP prolyl isomerase 5
	Synonyms	FKBP51\|FKBP54\|P54\|PPIase\|Ptg-10
	Gene type	protein_coding
	UniProtAcc	Q13451

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Dataset with differentially expressed gene: FKBP5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.391979	3.74e-14
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.393431	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.33256	2.95e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.265947	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.399669	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.728342	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.428031	2.09e-30
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.550304	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.439674	1.09e-14
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.497779	1.71e-11
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.605139	1.21e-07
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	1.30999	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	0.674016	6.81e-18
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	NK cells	0.954933	1.29e-03
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	CD4+ T cells	0.251797	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.936089	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD4+ T cells	0.282664	1.12e-16
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.736998	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	cDCs	0.875247	4.30e-05
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.832279	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	0.349417	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Malignant cells	-0.361459	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.492541	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.410036	7.33e-27
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.472081	8.11e-23
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.34519	2.88e-14

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Expression of FKBP5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FKBP5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FKBP5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FKBP5	hsa-miR-5011-5p	99.9991	NM_001145777
FKBP5	hsa-miR-1277-5p	99.9487	NM_001145777
FKBP5	hsa-miR-190a-3p	99.8446	NM_001145777
FKBP5	hsa-miR-5692b	99.7401	NM_001145777
FKBP5	hsa-miR-5692c	99.7401	NM_001145777
FKBP5	hsa-miR-2052	98.9801	NM_001145777
FKBP5	hsa-miR-3915	97.6488	NM_001145777
FKBP5	hsa-miR-335-3p	96.6192	NM_001145777
FKBP5	hsa-miR-3163	94.4473	NM_001145777
FKBP5	hsa-miR-2278	94.3154	NM_001145777
FKBP5	hsa-miR-3153	93.6245	NM_001145777
FKBP5	hsa-miR-9983-3p	93.1799	NM_001145775
FKBP5	hsa-miR-6739-5p	92.9978	NM_001145777
FKBP5	hsa-miR-4468	92.9616	NM_001145777
FKBP5	hsa-miR-1252-3p	92.3516	NM_001145775
FKBP5	hsa-miR-548aj-3p	91.7619	NM_001145775
FKBP5	hsa-miR-548x-3p	91.7619	NM_001145775
FKBP5	hsa-miR-1279	91.4312	NM_001145777
FKBP5	hsa-miR-3613-3p	91.2532	NM_001145777
FKBP5	hsa-miR-892a	90.9757	NM_001145775
FKBP5	hsa-miR-6733-5p	90.9347	NM_001145777
FKBP5	hsa-miR-129-5p	90.3061	NM_001145775
FKBP5	hsa-miR-223-3p	90.0417	NM_001145777
FKBP5	hsa-miR-548ae-3p	89.8326	NM_001145775
FKBP5	hsa-miR-548am-3p	89.8326	NM_001145775
FKBP5	hsa-miR-548j-3p	89.8326	NM_001145775
FKBP5	hsa-miR-548aq-3p	89.8326	NM_001145775
FKBP5	hsa-miR-548ah-3p	89.8326	NM_001145775
FKBP5	hsa-miR-101-5p	89.5599	NM_001145775
FKBP5	hsa-miR-1229-3p	88.5316	NM_001145777
FKBP5	hsa-miR-4725-3p	88.4052	NM_001145775
FKBP5	hsa-miR-6780b-5p	88.4052	NM_001145775
FKBP5	hsa-miR-651-5p	87.8779	NM_001145775
FKBP5	hsa-miR-661	87.1528	NM_001145777
FKBP5	hsa-miR-122-5p	86.9814	NM_001145775
FKBP5	hsa-miR-6086	86.4888	NM_001145777
FKBP5	hsa-miR-377-5p	86.4888	NM_001145777
FKBP5	hsa-miR-4685-5p	86.4644	NM_001145777
FKBP5	hsa-miR-520g-5p	85.769	NM_001145777
FKBP5	hsa-miR-4271	85.7137	NM_001145775
FKBP5	hsa-miR-5688	85.6577	NM_001145775
FKBP5	hsa-miR-12136	85.5882	NM_001145775
FKBP5	hsa-miR-4503	85.0458	NM_001145775
FKBP5	hsa-miR-19b-1-5p	84.6885	NM_001145777
FKBP5	hsa-miR-19b-2-5p	84.6885	NM_001145777
FKBP5	hsa-miR-5196-5p	84.2985	NM_001145777
FKBP5	hsa-miR-4747-5p	84.2985	NM_001145777
FKBP5	hsa-miR-3202	84.0997	NM_001145777
FKBP5	hsa-miR-6511b-3p	84.0308	NM_001145777
FKBP5	hsa-miR-6511a-3p	84.0308	NM_001145777

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Motifs and transcription factors (TFs) regulating FKBP5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FKBP5	transfac_pro__M06417	ZNF771 (directAnnotation).
FKBP5	metacluster_134.1	ZFP69 (directAnnotation).
FKBP5	transfac_pro__M06405	ZNF329 (directAnnotation).
FKBP5	transfac_pro__M05690	ZNF20 (directAnnotation).
FKBP5	transfac_pro__M05738	ZNF470 (directAnnotation).
FKBP5	transfac_pro__M06314	ZNF239 (directAnnotation).
FKBP5	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANNRTMAAYAN_CAP_repr	ELK1; FOXI1 (directAnnotation).
FKBP5	metacluster_162.2	BCL11A; ESR1; ESR1; ESR1; ESR1; ESR1; ESR1; ESR1; ESR1; ESR1; ESR1; ESR1; ESR2; ESR2; ESR2; ESR2; ESR2; ESRRA; ESRRA; PPARG; PPARG; PPARG; RARG (directAnnotation). ESR1; ESR1 (inferredBy_Orthology).
FKBP5	taipale_tf_pairs__PITX1_TBX21_AGGTGNGAARGGATTA_CAP_repr	PITX1; TBX21 (directAnnotation).
FKBP5	metacluster_187.3	SPDEF; SPDEF (directAnnotation).
FKBP5	transfac_pro__M06163	ZNF121 (directAnnotation).
FKBP5	kznf__CTCF_Transfac.7_Transfac	CTCF (directAnnotation).
FKBP5	homer__TYTGACCASWRG_Bcl11a	BCL11A (directAnnotation).
FKBP5	transfac_pro__M05822	ZNF546 (directAnnotation).
FKBP5	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
FKBP5	transfac_pro__M06301	ZNF404 (directAnnotation).
FKBP5	transfac_pro__M06438	ZNF227 (directAnnotation).
FKBP5	metacluster_58.12	BATF; FOSL1; FOSL1 (directAnnotation).
FKBP5	transfac_pro__M06966	E4F1 (inferredBy_Orthology).
FKBP5	jaspar__MA0442.2	SOX10 (directAnnotation).
FKBP5	taipale_cyt_meth__ASCL2_ACACGACGCN_FL_repr	ASCL2 (directAnnotation).
FKBP5	transfac_pro__M07448	ZBED1 (directAnnotation).
FKBP5	taipale_cyt_meth__FOXO3_NTCCCCACACN_eDBD	FOXO3 (directAnnotation).
FKBP5	jaspar__MA1657.1	ZNF652 (directAnnotation).
FKBP5	metacluster_172.6	CHD2; E2F1 (directAnnotation).
FKBP5	taipale_tf_pairs__ERF_MAX_RSCGGAANCACGTGN_CAP_repr	ERF; MAX (directAnnotation).
FKBP5	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
FKBP5	transfac_pro__M05985	ZNF394 (inferredBy_Orthology).
FKBP5	metacluster_155.36	ZNF729 (directAnnotation).
FKBP5	transfac_pro__M06586	ZNF479 (directAnnotation).
FKBP5	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
FKBP5	transfac_pro__M06556	ZNF383 (directAnnotation).
FKBP5	metacluster_155.21	ZNF454; ZNF454 (directAnnotation).
FKBP5	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
FKBP5	transfac_pro__M06071	ZNF814 (directAnnotation).
FKBP5	transfac_pro__M05995	ZNF180 (directAnnotation).
FKBP5	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
FKBP5	tfdimers__MD00421	ELF3; POU5F1 (directAnnotation).
FKBP5	taipale_tf_pairs__E2F3_FOXO6_NMATGACACNGCGCCMNN_CAP	E2F3; FOXO6 (directAnnotation).
FKBP5	transfac_pro__M01250	E2F1 (directAnnotation).
FKBP5	tfdimers__MD00432	DBP; STAT1 (directAnnotation).
FKBP5	transfac_pro__M06064	ZNF729 (directAnnotation).
FKBP5	jaspar__MA0601.1	ARID3B (inferredBy_Orthology).
FKBP5	metacluster_9.51	TLX2 (directAnnotation).
FKBP5	tfdimers__MD00567	IKZF2 (directAnnotation).
FKBP5	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
FKBP5	swissregulon__hs__ZNF652	ZNF652 (directAnnotation).
FKBP5	metacluster_182.3	GCM1; GCM1; GCM1; GCM1; GCM1; GCM1; GCM2; GCM2; GCM2; GCM2; GCM2 (directAnnotation). GCM1; GCM1; GCM1; GCM1; GCM1; GCM1; GCM2; GCM2; GCM2; GCM2; GCM2; GCM2 (inferredBy_Orthology).
FKBP5	tfdimers__MD00261	PDX1 (directAnnotation).
FKBP5	transfac_pro__M06569	ZNF775 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."