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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZNF292

Summary for ZNF292

Gene information	Gene symbol	ZNF292
	Ensembl ID	ENSG00000188994
	Entrez ID	23036
	Gene name	zinc finger protein 292
	Synonyms	bA393I2.3\|KIAA0530\|ZFP292\|Zn-15\|Zn-16
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ZNF292

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.524979	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.423127	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.2764	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.758491	0.00e+00
GSE150930	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Mucosa-assisted lymphoid tissue (MALT) lymphoma	Immunotherapy	rituximab + cyclophosphamide + fludarabine	NA	Malignant cells	-0.267365	4.72e-07
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.443044	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.488103	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.546413	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.330292	2.02e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.263664	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.557079	4.24e-30

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Expression of ZNF292 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZNF292

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZNF292

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZNF292	hsa-miR-144-5p	97.6624	NM_015021
ZNF292	hsa-miR-3065-5p	97.4526	NM_015021
ZNF292	hsa-miR-4437	97.1862	NM_015021
ZNF292	hsa-miR-3613-3p	96.2304	NM_015021
ZNF292	hsa-miR-3163	95.7963	NM_015021
ZNF292	hsa-miR-505-3p	93.784	NM_015021
ZNF292	hsa-let-7f-1-3p	93.2369	NM_015021
ZNF292	hsa-miR-98-3p	93.2369	NM_015021
ZNF292	hsa-let-7a-3p	93.2369	NM_015021
ZNF292	hsa-let-7b-3p	93.2369	NM_015021
ZNF292	hsa-miR-6516-3p	92.9204	NM_015021
ZNF292	hsa-miR-1283	89.1627	NM_015021
ZNF292	hsa-miR-9-3p	88.8288	NM_015021
ZNF292	hsa-miR-6776-5p	88.6691	NM_015021
ZNF292	hsa-miR-548c-3p	87.7108	NM_015021
ZNF292	hsa-miR-3171	87.4495	NM_015021
ZNF292	hsa-miR-340-5p	86.978	NM_015021
ZNF292	hsa-miR-1972	86.6644	NM_015021
ZNF292	hsa-miR-6757-5p	86.3199	NM_015021
ZNF292	hsa-miR-1290	86.0579	NM_015021
ZNF292	hsa-miR-4445-3p	85.9547	NM_015021
ZNF292	hsa-miR-1277-5p	84.9546	NM_015021
ZNF292	hsa-miR-3646	84.5567	NM_015021
ZNF292	hsa-miR-23a-3p	83.9938	NM_015021
ZNF292	hsa-miR-23c	83.9938	NM_015021
ZNF292	hsa-miR-23b-3p	83.9938	NM_015021
ZNF292	hsa-miR-1185-2-3p	83.4868	NM_015021
ZNF292	hsa-miR-1185-1-3p	83.4868	NM_015021
ZNF292	hsa-let-7f-2-3p	83.4868	NM_015021
ZNF292	hsa-miR-3529-3p	83.1364	NM_015021
ZNF292	hsa-miR-5696	83.1009	NM_015021
ZNF292	hsa-miR-5688	82.8814	NM_015021
ZNF292	hsa-miR-5000-5p	82.7303	NM_015021
ZNF292	hsa-miR-4307	82.316	NM_015021
ZNF292	hsa-miR-548as-3p	82.1738	NM_015021
ZNF292	hsa-miR-8058	82.0036	NM_015021
ZNF292	hsa-miR-495-3p	81.5489	NM_015021
ZNF292	hsa-miR-33a-3p	81.0781	NM_015021
ZNF292	hsa-miR-5009-5p	80.4492	NM_015021
ZNF292	hsa-miR-548g-3p	80.2971	NM_015021
ZNF292	hsa-miR-548al	80.2923	NM_015021

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Motifs and transcription factors (TFs) regulating ZNF292

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZNF292	transfac_pro__M12694	ZFP14 (directAnnotation).
ZNF292	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
ZNF292	swissregulon__hs__KLF6	KLF6 (directAnnotation).
ZNF292	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
ZNF292	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
ZNF292	transfac_pro__M09837	ZNF449 (directAnnotation).
ZNF292	hdpi__EBF1	EBF1 (directAnnotation).
ZNF292	hdpi__GTF3C2	GTF3C2 (directAnnotation).
ZNF292	transfac_pro__M08005	TCFL5 (inferredBy_Orthology).
ZNF292	transfac_pro__M03876	ZBTB33 (directAnnotation).
ZNF292	transfac_pro__M04646	FOXN4 (directAnnotation).
ZNF292	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
ZNF292	transfac_pro__M01858	TFAP2B (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."