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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TRAM1

Summary for TRAM1

Gene information	Gene symbol	TRAM1
	Ensembl ID	ENSG00000067167
	Entrez ID	23471
	Gene name	translocation associated membrane protein 1
	Synonyms	TRAM\|TRAMP
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: TRAM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.293587	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.3007	5.80e-14
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	-0.543537	8.94e-03
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	-0.271536	2.89e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.655043	7.49e-37
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.279434	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.629103	3.21e-29
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.297427	2.89e-32
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.574131	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.463473	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.252739	2.19e-08
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.264502	2.52e-05
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.350851	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-2.19396	0.00e+00

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Expression of TRAM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TRAM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TRAM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TRAM1	hsa-miR-5011-5p	99.9996	NM_014294
TRAM1	hsa-miR-190a-3p	99.9948	NM_014294
TRAM1	hsa-miR-4307	99.8242	NM_014294
TRAM1	hsa-miR-6835-3p	98.8399	NM_014294
TRAM1	hsa-miR-3163	98.1809	NM_014294
TRAM1	hsa-miR-1225-3p	97.2931	NM_014294
TRAM1	hsa-miR-2110	96.5541	NM_014294
TRAM1	hsa-miR-1266-3p	95.7528	NM_014294
TRAM1	hsa-miR-6857-5p	95.5841	NM_014294
TRAM1	hsa-miR-200a-3p	95.5671	NM_014294
TRAM1	hsa-miR-141-3p	95.5671	NM_014294
TRAM1	hsa-miR-6810-5p	94.7508	NM_014294
TRAM1	hsa-miR-155-5p	94.162	NM_014294
TRAM1	hsa-miR-7853-5p	93.8775	NM_014294
TRAM1	hsa-miR-105-5p	93.8775	NM_014294
TRAM1	hsa-miR-5579-5p	92.7647	NM_014294
TRAM1	hsa-miR-4728-3p	92.6541	NM_014294
TRAM1	hsa-miR-4766-5p	92.6055	NM_014294
TRAM1	hsa-miR-218-1-3p	92.5808	NM_014294
TRAM1	hsa-miR-183-5p	92.1014	NM_014294
TRAM1	hsa-miR-3925-5p	91.8203	NM_014294
TRAM1	hsa-miR-1277-5p	91.8012	NM_014294
TRAM1	hsa-miR-1185-1-3p	91.4638	NM_014294
TRAM1	hsa-let-7f-2-3p	91.4638	NM_014294
TRAM1	hsa-miR-1185-2-3p	91.4638	NM_014294
TRAM1	hsa-miR-5197-5p	91.2592	NM_014294
TRAM1	hsa-miR-3150a-3p	91.1833	NM_014294
TRAM1	hsa-miR-6763-5p	91.1833	NM_014294
TRAM1	hsa-miR-3191-3p	90.697	NM_014294
TRAM1	hsa-miR-548ak	89.6482	NM_014294
TRAM1	hsa-miR-548w	89.6482	NM_014294
TRAM1	hsa-miR-548y	89.6482	NM_014294
TRAM1	hsa-miR-548ad-5p	89.6482	NM_014294
TRAM1	hsa-miR-548as-5p	89.6482	NM_014294
TRAM1	hsa-miR-548ay-5p	89.6482	NM_014294
TRAM1	hsa-miR-548h-5p	89.6482	NM_014294
TRAM1	hsa-miR-548ap-5p	89.6482	NM_014294
TRAM1	hsa-miR-548bb-5p	89.6482	NM_014294
TRAM1	hsa-miR-548o-5p	89.6482	NM_014294
TRAM1	hsa-miR-559	89.6482	NM_014294
TRAM1	hsa-miR-548ar-5p	89.6482	NM_014294
TRAM1	hsa-miR-548a-5p	89.6482	NM_014294
TRAM1	hsa-miR-548au-5p	89.6482	NM_014294
TRAM1	hsa-miR-548j-5p	89.6482	NM_014294
TRAM1	hsa-miR-548am-5p	89.6482	NM_014294
TRAM1	hsa-miR-548b-5p	89.6482	NM_014294
TRAM1	hsa-miR-548d-5p	89.6482	NM_014294
TRAM1	hsa-miR-548i	89.6482	NM_014294
TRAM1	hsa-miR-548ae-5p	89.6482	NM_014294
TRAM1	hsa-miR-548ab	89.6482	NM_014294

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Motifs and transcription factors (TFs) regulating TRAM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TRAM1	transfac_pro__M04816	BCL3 (directAnnotation).
TRAM1	transfac_pro__M05609	SALL3 (directAnnotation).
TRAM1	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
TRAM1	swissregulon__hs__ZBTB7A	ZBTB7A (directAnnotation).
TRAM1	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
TRAM1	transfac_pro__M06035	ZNF749 (directAnnotation).
TRAM1	transfac_public__M00051	NFKB1 (directAnnotation).
TRAM1	transfac_pro__M05915	ZBTB20 (directAnnotation).
TRAM1	tfdimers__MD00028	ETS1; GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation).
TRAM1	tfdimers__MD00503	EBF1; MZF1 (directAnnotation).
TRAM1	tfdimers__MD00010	TP53; TP63; TP73 (directAnnotation).
TRAM1	taipale_cyt_meth__ELF3_NATAACGGATGYN_eDBD_repr	ELF3 (directAnnotation).
TRAM1	taipale_cyt_meth__OLIG2_AACAGCTGTY_eDBD	OLIG2 (directAnnotation).
TRAM1	transfac_pro__M06164	ZNF157 (directAnnotation).
TRAM1	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
TRAM1	jaspar__MA1650.1	ZBTB14 (directAnnotation).
TRAM1	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
TRAM1	metacluster_175.5	IRX3; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP63; TP63; TP63; TP63; TP63; TP63; TP73; TP73; TP73; TP73; TP73; TP73 (directAnnotation). TP53; TP53; TP53; TP73 (inferredBy_Orthology).
TRAM1	metacluster_173.2	ATF3; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; BATF3; CREB3; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L4; XBP1; XBP1; XBP1; XBP1 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."