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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PDE4B

Summary for PDE4B

Gene information	Gene symbol	PDE4B
	Ensembl ID	ENSG00000184588
	Entrez ID	5142
	Gene name	phosphodiesterase 4B
	Synonyms	DPDE4
	Gene type	protein_coding
	UniProtAcc	Q07343

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Dataset with differentially expressed gene: PDE4B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.389198	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	-0.358245	4.55e-07
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.359089	3.12e-23
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.274644	4.94e-13
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.546966	5.27e-20
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.292622	1.27e-09
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	0.251637	3.20e-42
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.363683	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.50108	3.47e-12
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.49959	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	pDCs	0.918392	7.33e-03
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	-0.362996	1.45e-04
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.639318	1.06e-11
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.403608	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.712872	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.308282	1.41e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.559683	2.12e-14
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.334362	3.15e-26
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.299869	2.15e-23
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.339194	2.11e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.344009	1.14e-13
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.744191	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.291817	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.325647	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.567286	0.00e+00

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Expression of PDE4B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PDE4B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PDE4B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PDE4B	hsa-miR-23a-3p	99.8175	NM_001037339
PDE4B	hsa-miR-23c	99.8175	NM_001037339
PDE4B	hsa-miR-23b-3p	99.8175	NM_001037339
PDE4B	hsa-miR-5011-5p	98.042	NM_001037339
PDE4B	hsa-miR-410-3p	97.951	NM_001037339
PDE4B	hsa-miR-323a-3p	97.1445	NM_001297440
PDE4B	hsa-miR-369-3p	96.9931	NM_001297440
PDE4B	hsa-miR-374b-5p	94.6562	NM_001037339
PDE4B	hsa-miR-374a-5p	94.6562	NM_001037339
PDE4B	hsa-miR-494-3p	94.2174	NM_001297440
PDE4B	hsa-miR-4803	93.9489	NM_001037339
PDE4B	hsa-miR-3120-3p	92.3654	NM_001297440
PDE4B	hsa-miR-3613-3p	92.2659	NM_001037339
PDE4B	hsa-miR-7150	91.8303	NM_001297440
PDE4B	hsa-miR-498-5p	91.1217	NM_001037339
PDE4B	hsa-miR-124-3p	90.5769	NM_001037339
PDE4B	hsa-miR-506-3p	90.5769	NM_001037339
PDE4B	hsa-miR-338-5p	89.6118	NM_001037339
PDE4B	hsa-miR-12136	89.584	NM_001037339
PDE4B	hsa-miR-4670-3p	88.1082	NM_001297440
PDE4B	hsa-miR-4684-5p	86.674	NM_001037339
PDE4B	hsa-miR-142-3p	86.1093	NM_001037339
PDE4B	hsa-miR-12125	86.0478	NM_001037339
PDE4B	hsa-miR-3166	85.9867	NM_001037339
PDE4B	hsa-miR-222-5p	85.6974	NM_001037339
PDE4B	hsa-miR-524-5p	85.428	NM_001037339
PDE4B	hsa-miR-520d-5p	85.428	NM_001037339
PDE4B	hsa-miR-8084	85.055	NM_001297440
PDE4B	hsa-miR-549a-5p	84.6479	NM_001297440
PDE4B	hsa-miR-548an	84.0492	NM_001037339
PDE4B	hsa-miR-4742-5p	83.6325	NM_001037339
PDE4B	hsa-miR-4778-5p	83.6209	NM_001037339
PDE4B	hsa-miR-584-3p	83.3902	NM_001037339
PDE4B	hsa-miR-361-5p	82.7701	NM_001297440
PDE4B	hsa-miR-6499-3p	82.4727	NM_001297440
PDE4B	hsa-miR-4738-3p	82.3678	NM_001037339
PDE4B	hsa-miR-340-5p	81.4369	NM_001037339
PDE4B	hsa-miR-4677-3p	81.3215	NM_001297440
PDE4B	hsa-miR-519d-5p	81.2098	NM_001037339
PDE4B	hsa-miR-199b-3p	81.0198	NM_001037339
PDE4B	hsa-miR-3129-5p	81.0198	NM_001037339
PDE4B	hsa-miR-199a-3p	81.0198	NM_001037339
PDE4B	hsa-miR-21-3p	80.9964	NM_001037339
PDE4B	hsa-miR-122b-3p	80.9964	NM_001037339
PDE4B	hsa-miR-4640-3p	80.7955	NM_001297440
PDE4B	hsa-miR-4766-5p	80.6383	NM_001037339
PDE4B	hsa-miR-20b-3p	80.6339	NM_001297440
PDE4B	hsa-miR-1252-5p	80.088	NM_001037339

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Motifs and transcription factors (TFs) regulating PDE4B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PDE4B	transfac_pro__M05971	ZNF860 (directAnnotation).
PDE4B	taipale_tf_pairs__CUX1_SRF_NCCATAYWNGGWNNNNATCRATN_CAP_repr	CUX1; SRF (directAnnotation).
PDE4B	transfac_pro__M05573	ZNF213 (directAnnotation).
PDE4B	transfac_pro__M05590	ZNF772 (directAnnotation).
PDE4B	metacluster_68.7	MEIS2; MEIS2; MEIS2; MEIS2; MEIS2; MEIS2; MEIS3; MEIS3; MEIS3; PKNOX1; PKNOX1; PKNOX1; PKNOX1; PKNOX1; PKNOX2; PKNOX2; PKNOX2; TGIF1; TGIF1; TGIF1; TGIF2; TGIF2; TGIF2; TGIF2LX; TGIF2LX; TGIF2LX; TGIF2LX; TGIF2LX; TGIF2LY; TGIF2LY (directAnnotation). MEIS1; MEIS1; MEIS1; MEIS1; MEIS2; MEIS2; MEIS2; MEIS3; MEIS3; MEIS3; MEIS3; PBX1; PBX1; PBX1; PBX2; PBX2; PBX2; PBX3; PBX3; PBX3; PBX4; PBX4; PBX4; PKNOX1; PKNOX1; PKNOX1; PKNOX2; PKNOX2; PKNOX2; PKNOX2; TGIF1; TGIF1; TGIF1; TGIF2; TGIF2; TGIF2; TGIF2LX; TGIF2LX; TGIF2LX; TGIF2LY; TGIF2LY; TGIF2LY (inferredBy_Orthology).
PDE4B	taipale_cyt_meth__HSF5_AACRTTCTAGAAYGYT_eDBD_meth	HSF5 (directAnnotation).
PDE4B	transfac_pro__M04840	MEF2C (directAnnotation).
PDE4B	tfdimers__MD00012	ETS1; YY1 (directAnnotation).
PDE4B	metacluster_88.3	ZNF513 (directAnnotation).
PDE4B	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
PDE4B	tfdimers__MD00226	ETS2; MYB (directAnnotation).
PDE4B	transfac_pro__M06667	ZNF599 (directAnnotation).
PDE4B	tfdimers__MD00190	ARID3A; WT1 (directAnnotation).
PDE4B	kznf__ZNF582_Imbeault2017_OM_MEME	ZNF582 (directAnnotation).
PDE4B	transfac_pro__M05961	ZNF407 (directAnnotation).
PDE4B	tfdimers__MD00168	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6; PAX4 (directAnnotation).
PDE4B	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
PDE4B	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
PDE4B	taipale_tf_pairs__PITX1_FIGLA_TAATCCNNNNCASSTG_CAP_repr	FIGLA; PITX1 (directAnnotation).
PDE4B	transfac_pro__M06025	ZNF195 (directAnnotation).
PDE4B	transfac_pro__M05852	ZNF689 (directAnnotation).
PDE4B	taipale_tf_pairs__GCM2_DLX2_RTRCGGGNNNNNTAATTR_CAP_repr	DLX2; GCM2 (directAnnotation).
PDE4B	transfac_pro__M04890	BATF (directAnnotation).
PDE4B	transfac_pro__M06907	ZFP3 (inferredBy_Orthology).
PDE4B	tfdimers__MD00052	GFI1; GFI1B; YY1 (directAnnotation).
PDE4B	transfac_pro__M01229	GTF2IRD1 (directAnnotation).
PDE4B	transfac_pro__M06062	ZNF623 (directAnnotation).
PDE4B	metacluster_131.3	ZNF436 (inferredBy_Orthology).
PDE4B	transfac_pro__M12586	MYBL2 (directAnnotation).
PDE4B	taipale_tf_pairs__HOXB2_PAX1_NNMATTAGTCACGCWTSRNTG_CAP_repr	HOXB2; PAX1 (directAnnotation).
PDE4B	transfac_pro__M04927	FOXA1 (directAnnotation).
PDE4B	transfac_pro__M05601	FIZ1 (directAnnotation).
PDE4B	transfac_pro__M06426	ZNF761 (directAnnotation).
PDE4B	transfac_pro__M01081	ZNF628 (directAnnotation).
PDE4B	transfac_pro__M06646	ZNF607 (directAnnotation).
PDE4B	transfac_pro__M02080	ISL2 (directAnnotation).
PDE4B	jaspar__MA1562.1	SOX14 (directAnnotation).
PDE4B	metacluster_65.19	HSF1 (directAnnotation).
PDE4B	tfdimers__MD00335	FOXP3; NKX2-1 (directAnnotation).
PDE4B	taipale_tf_pairs__TEAD4_SPDEF_RGAATGCGGATN_CAP	SPDEF; TEAD4 (directAnnotation).
PDE4B	transfac_pro__M06433	ZNF571 (directAnnotation).
PDE4B	transfac_pro__M05545	IKZF4 (inferredBy_Orthology).
PDE4B	tfdimers__MD00542	E2F1; EBF1 (directAnnotation).
PDE4B	tfdimers__MD00016	MYCN (directAnnotation).
PDE4B	taipale_tf_pairs__HOXB2_HOXB13_NNATCATNGTAAA_CAP_repr	HOXB13; HOXB2 (directAnnotation).
PDE4B	transfac_pro__M06073	ZNF749 (directAnnotation).
PDE4B	transfac_pro__M06966	E4F1 (inferredBy_Orthology).
PDE4B	transfac_public__M00086	IKZF1 (directAnnotation).
PDE4B	transfac_pro__M06754	ZBTB39 (directAnnotation).
PDE4B	transfac_pro__M06749	ZNF222 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PDE4B	"(R)-Rolipram"	DB04149	small molecule
PDE4B	"(S)-Rolipram"	DB03606	small molecule
PDE4B	"1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester"	DB03807	small molecule
PDE4B	"1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide	DB06909	small molecule
PDE4B	"3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester"	DB01959	small molecule
PDE4B	"4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid"	DB08299	small molecule
PDE4B	"8-Bromo-Adenosine-5'-Monophosphate"	DB03349	small molecule
PDE4B	"Adenosine phosphate"	DB00131	small molecule
PDE4B	"Caffeine"	DB00201	small molecule
PDE4B	"Cilomilast"	DB03849	small molecule
PDE4B	"Crisaborole"	DB05219	small molecule
PDE4B	"Daxalipram"	DB01647	small molecule
PDE4B	"Dyphylline"	DB00651	small molecule
PDE4B	"Enprofylline"	DB00824	small molecule
PDE4B	"Filaminast"	DB02660	small molecule
PDE4B	"Ibudilast"	DB05266	small molecule
PDE4B	"Iloprost"	DB01088	small molecule
PDE4B	"Papaverine"	DB01113	small molecule
PDE4B	"Piclamilast"	DB01791	small molecule
PDE4B	"Rolipram"	DB01954	small molecule
PDE4B	"S,S-(2-Hydroxyethyl)Thiocysteine"	DB04530	small molecule
PDE4B	"Theobromine"	DB01412	small molecule
PDE4B	"Theophylline"	DB00277	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."