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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LMO4

Summary for LMO4

Gene information	Gene symbol	LMO4
	Ensembl ID	ENSG00000143013
	Entrez ID	8543
	Gene name	LIM domain only 4
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P61968

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Dataset with differentially expressed gene: LMO4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.839652	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.443038	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.716478	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mast cells	-1.17802	1.03e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.338742	2.57e-07
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.450778	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.484799	2.06e-31
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	1.79558	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.273122	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.277713	5.80e-33
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.91781	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	-0.577285	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.799779	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.437487	0.00e+00

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Expression of LMO4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LMO4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LMO4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LMO4	hsa-miR-4679	98.4209	NM_006769
LMO4	hsa-miR-4719	97.9025	NM_006769
LMO4	hsa-miR-4291	97.5808	NM_006769
LMO4	hsa-miR-545-3p	96.0503	NM_006769
LMO4	hsa-miR-4795-3p	94.8681	NM_006769
LMO4	hsa-miR-146a-3p	94.4583	NM_006769
LMO4	hsa-miR-1289	93.486	NM_006769
LMO4	hsa-miR-335-3p	93.4546	NM_006769
LMO4	hsa-miR-2053	91.4928	NM_006769
LMO4	hsa-miR-1236-5p	90.6848	NM_006769
LMO4	hsa-miR-4713-3p	90.186	NM_006769
LMO4	hsa-miR-4693-5p	90.1606	NM_006769
LMO4	hsa-miR-6799-3p	90.051	NM_006769
LMO4	hsa-miR-3173-5p	90.051	NM_006769
LMO4	hsa-miR-302f	89.9176	NM_006769
LMO4	hsa-miR-4666a-3p	89.5318	NM_006769
LMO4	hsa-miR-593-3p	88.9571	NM_006769
LMO4	hsa-miR-934	88.274	NM_006769
LMO4	hsa-miR-186-5p	88.1087	NM_006769
LMO4	hsa-miR-4659a-3p	87.3865	NM_006769
LMO4	hsa-miR-4659b-3p	87.3865	NM_006769
LMO4	hsa-miR-3529-3p	86.0693	NM_006769
LMO4	hsa-miR-5689	85.8244	NM_006769
LMO4	hsa-miR-143-3p	85.7731	NM_006769
LMO4	hsa-miR-4770	85.7731	NM_006769
LMO4	hsa-miR-4672	85.4689	NM_006769
LMO4	hsa-miR-1250-3p	85.2409	NM_006769
LMO4	hsa-miR-642a-5p	84.549	NM_006769
LMO4	hsa-miR-6875-3p	83.9936	NM_006769
LMO4	hsa-miR-211-3p	83.7737	NM_006769
LMO4	hsa-miR-153-5p	83.2931	NM_006769
LMO4	hsa-miR-4704-3p	83.2678	NM_006769
LMO4	hsa-miR-3659	82.4539	NM_006769
LMO4	hsa-miR-4756-3p	82.1139	NM_006769
LMO4	hsa-miR-409-3p	81.7101	NM_006769
LMO4	hsa-miR-655-3p	81.578	NM_006769
LMO4	hsa-miR-374c-5p	81.578	NM_006769
LMO4	hsa-miR-8070	81.4453	NM_006769
LMO4	hsa-miR-8056	80.9108	NM_006769
LMO4	hsa-miR-4293	80.8148	NM_006769

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Motifs and transcription factors (TFs) regulating LMO4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LMO4	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
LMO4	transfac_pro__M04913	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."