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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: EML4

Summary for EML4

Gene information	Gene symbol	EML4
	Ensembl ID	ENSG00000143924
	Entrez ID	27436
	Gene name	EMAP like 4
	Synonyms	C2orf2\|ELP120\|ROPP120
	Gene type	protein_coding
	UniProtAcc	Q9HC35

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Dataset with differentially expressed gene: EML4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.453106	7.11e-36
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.285418	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.294569	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.266148	1.95e-26
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.406936	2.34e-25
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.473875	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.443192	2.44e-19
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.263845	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.309363	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	0.621557	5.96e-16
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.44745	4.53e-36
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	CD4+ T cells	-0.4443	2.78e-05
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	CD8+ T cells	-0.293746	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.855153	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.538535	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.711534	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.436307	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.609064	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.266793	2.29e-09
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	CD4+ T cells	-0.438507	1.11e-06

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Expression of EML4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to EML4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating EML4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
EML4	hsa-miR-499a-5p	98.6429	NM_001145076
EML4	hsa-miR-4717-3p	96	NM_001145076
EML4	hsa-miR-30d-5p	95.9587	NM_001145076
EML4	hsa-miR-30b-5p	95.9587	NM_001145076
EML4	hsa-miR-30a-5p	95.9587	NM_001145076
EML4	hsa-miR-30e-5p	95.9587	NM_001145076
EML4	hsa-miR-30c-5p	95.9587	NM_001145076
EML4	hsa-miR-12124	95.6082	NM_001145076
EML4	hsa-miR-1202	95.1695	NM_001145076
EML4	hsa-miR-3972	95.1695	NM_001145076
EML4	hsa-miR-494-3p	94.4875	NM_001145076
EML4	hsa-miR-3148	93.9557	NM_001145076
EML4	hsa-miR-5700	93.2792	NM_001145076
EML4	hsa-miR-3193	92.9883	NM_001145076
EML4	hsa-miR-4324	92.6293	NM_001145076
EML4	hsa-miR-8087	92.3706	NM_001145076
EML4	hsa-miR-6738-3p	92.3351	NM_001145076
EML4	hsa-miR-513b-5p	92.1905	NM_001145076
EML4	hsa-miR-4496	92.1428	NM_001145076
EML4	hsa-miR-3614-5p	91.5771	NM_001145076
EML4	hsa-miR-4727-5p	90.739	NM_001145076
EML4	hsa-miR-371a-5p	90.3546	NM_001145076
EML4	hsa-miR-329-5p	89.8123	NM_001145076
EML4	hsa-miR-216a-5p	88.6465	NM_001145076
EML4	hsa-miR-570-3p	88.0314	NM_001145076
EML4	hsa-miR-4524a-3p	87.9879	NM_001145076
EML4	hsa-miR-125b-2-3p	87.8571	NM_001145076
EML4	hsa-miR-676-5p	87.4208	NM_001145076
EML4	hsa-miR-29b-3p	87.4169	NM_001145076
EML4	hsa-miR-29a-3p	87.4169	NM_001145076
EML4	hsa-miR-29c-3p	87.4169	NM_001145076
EML4	hsa-miR-1252-5p	87.365	NM_001145076
EML4	hsa-miR-498-5p	87.1187	NM_001145076
EML4	hsa-miR-8065	86.9791	NM_001145076
EML4	hsa-miR-4261	86.7699	NM_001145076
EML4	hsa-miR-12113	86.7039	NM_001145076
EML4	hsa-miR-4539	86.7039	NM_001145076
EML4	hsa-miR-4797-3p	86.6794	NM_001145076
EML4	hsa-miR-4303	86.2793	NM_001145076
EML4	hsa-miR-5001-3p	86.1183	NM_001145076
EML4	hsa-miR-466	85.0165	NM_001145076
EML4	hsa-miR-4799-5p	84.6749	NM_001145076
EML4	hsa-miR-8063	84.6418	NM_001145076
EML4	hsa-miR-6501-5p	83.9331	NM_001145076
EML4	hsa-miR-873-3p	83.928	NM_001145076
EML4	hsa-miR-3686	83.2291	NM_001145076
EML4	hsa-miR-4709-3p	82.9489	NM_001145076
EML4	hsa-miR-770-5p	82.4568	NM_001145076
EML4	hsa-miR-4712-5p	82.4568	NM_001145076
EML4	hsa-miR-582-5p	82.2673	NM_001145076

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Motifs and transcription factors (TFs) regulating EML4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
EML4	transfac_pro__M07329	SP7 (directAnnotation).
EML4	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
EML4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
EML4	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
EML4	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
EML4	jaspar__MA0079.5	SP1 (directAnnotation).
EML4	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
EML4	hdpi__LARP1	LARP1 (directAnnotation).
EML4	transfac_pro__M06488	ZNF595 (directAnnotation).
EML4	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
EML4	transfac_pro__M02089	E2F3 (directAnnotation).
EML4	transfac_pro__M07317	CTBP1 (directAnnotation).
EML4	transfac_pro__M00716	ZBTB14 (directAnnotation).
EML4	transfac_pro__M03806	ZBTB7C (directAnnotation).
EML4	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
EML4	cisbp__M08228	PAX5 (directAnnotation).
EML4	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
EML4	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
EML4	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
EML4	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
EML4	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
EML4	transfac_pro__M03846	SMAD5 (directAnnotation).
EML4	metacluster_45.4	E2F2 (directAnnotation).
EML4	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
EML4	hdpi__FEZF2	FEZF2 (directAnnotation).
EML4	cisbp__M00343	PAX6 (directAnnotation).
EML4	transfac_pro__M12694	ZFP14 (directAnnotation).
EML4	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
EML4	cisbp__M00341	PAX6 (directAnnotation).
EML4	swissregulon__hs__KLF6	KLF6 (directAnnotation).
EML4	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
EML4	transfac_pro__M09837	ZNF449 (directAnnotation).
EML4	hdpi__EBF1	EBF1 (directAnnotation).
EML4	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
EML4	hdpi__GTF3C2	GTF3C2 (directAnnotation).
EML4	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
EML4	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
EML4	transfac_pro__M03876	ZBTB33 (directAnnotation).
EML4	transfac_pro__M04646	FOXN4 (directAnnotation).
EML4	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
EML4	transfac_pro__M04617	ZBTB7A (directAnnotation).
EML4	transfac_pro__M07436	WT1 (directAnnotation).
EML4	transfac_pro__M01858	TFAP2B (directAnnotation).
EML4	transfac_pro__M06391	ZNF836 (directAnnotation).
EML4	transfac_pro__M06071	ZNF814 (directAnnotation).
EML4	transfac_pro__M06259	ZNF91 (directAnnotation).
EML4	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
EML4	cisbp__M04023	CREB1 (directAnnotation).
EML4	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
EML4	cisbp__M01725	SREBF2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."