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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKRD28

Summary for ANKRD28

Gene information	Gene symbol	ANKRD28
	Ensembl ID	ENSG00000206560
	Entrez ID	23243
	Gene name	ankyrin repeat domain 28
	Synonyms	CFAP79\|FAP79\|KIAA0379\|PITK\|PP6-ARS-A\|PPP1R65
	Gene type	protein_coding
	UniProtAcc	O15084

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Dataset with differentially expressed gene: ANKRD28

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.390232	1.21e-28
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.408989	7.94e-07
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.620938	2.63e-32
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	0.494396	5.03e-06
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.465094	5.38e-43
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.470127	3.79e-26
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.68213	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.416919	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	Malignant cells	0.548275	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Malignant cells	0.815207	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	Erythrocytes	0.926365	1.26e-04
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.411034	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Mono/Macro	-0.305779	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.789258	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.573189	0.00e+00

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Expression of ANKRD28 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANKRD28

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKRD28

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKRD28	hsa-miR-3692-3p	97.6207	NM_001195098
ANKRD28	hsa-miR-548bb-3p	97.5465	NM_001195098
ANKRD28	hsa-miR-548d-3p	97.5465	NM_001195098
ANKRD28	hsa-miR-548ac	97.4059	NM_001195098
ANKRD28	hsa-miR-548h-3p	97.4059	NM_001195098
ANKRD28	hsa-miR-548z	97.4059	NM_001195098
ANKRD28	hsa-miR-548e-5p	97.0817	NM_001195098
ANKRD28	hsa-miR-892c-5p	95.9163	NM_001195098
ANKRD28	hsa-miR-92b-3p	95.2093	NM_001195098
ANKRD28	hsa-miR-32-5p	95.2093	NM_001195098
ANKRD28	hsa-miR-92a-3p	95.2093	NM_001195098
ANKRD28	hsa-miR-6835-3p	95.125	NM_001195098
ANKRD28	hsa-miR-137-3p	94.0045	NM_001195098
ANKRD28	hsa-miR-3686	93.913	NM_001195098
ANKRD28	hsa-miR-363-3p	93.8345	NM_001195098
ANKRD28	hsa-miR-367-3p	93.8345	NM_001195098
ANKRD28	hsa-miR-25-3p	93.8345	NM_001195098
ANKRD28	hsa-miR-548ap-3p	93.4543	NM_001195098
ANKRD28	hsa-miR-548t-3p	93.4543	NM_001195098
ANKRD28	hsa-miR-548aa	93.4543	NM_001195098
ANKRD28	hsa-miR-1256	93.4233	NM_001195098
ANKRD28	hsa-miR-340-5p	93.0703	NM_001195098
ANKRD28	hsa-miR-876-5p	92.9521	NM_001195098
ANKRD28	hsa-miR-133a-3p	92.4742	NM_001195098
ANKRD28	hsa-miR-133b	92.4742	NM_001195098
ANKRD28	hsa-miR-548as-3p	92.1821	NM_001195098
ANKRD28	hsa-miR-5195-3p	92.1118	NM_001195098
ANKRD28	hsa-miR-145-5p	92.1118	NM_001195098
ANKRD28	hsa-miR-607	92.0979	NM_001195098
ANKRD28	hsa-miR-3167	91.9855	NM_001195098
ANKRD28	hsa-miR-3059-5p	91.4974	NM_001195098
ANKRD28	hsa-miR-3133	91.1754	NM_001195098
ANKRD28	hsa-miR-548aj-3p	90.4751	NM_001195098
ANKRD28	hsa-miR-548x-3p	90.4751	NM_001195098
ANKRD28	hsa-miR-186-5p	90.3843	NM_001195098
ANKRD28	hsa-miR-548j-3p	90.0802	NM_001195098
ANKRD28	hsa-miR-548am-3p	90.0802	NM_001195098
ANKRD28	hsa-miR-548ae-3p	90.0802	NM_001195098
ANKRD28	hsa-miR-548ah-3p	90.0802	NM_001195098
ANKRD28	hsa-miR-548aq-3p	90.0802	NM_001195098
ANKRD28	hsa-miR-3913-3p	89.8783	NM_001195098
ANKRD28	hsa-miR-148b-5p	89.6871	NM_001195098
ANKRD28	hsa-miR-6874-3p	89.6871	NM_001195098
ANKRD28	hsa-miR-4255	89.5976	NM_001195098
ANKRD28	hsa-miR-4291	89.5722	NM_001195098
ANKRD28	hsa-miR-144-3p	89.2776	NM_001195098
ANKRD28	hsa-miR-1297	89.2645	NM_001195098
ANKRD28	hsa-miR-5197-5p	89.197	NM_001195098
ANKRD28	hsa-miR-138-2-3p	88.6781	NM_001195098
ANKRD28	hsa-miR-6833-3p	88.6371	NM_001195098

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Motifs and transcription factors (TFs) regulating ANKRD28

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANKRD28	transfac_pro__M06798	PRDM15 (directAnnotation).
ANKRD28	transfac_pro__M05982	ZFP14 (directAnnotation).
ANKRD28	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
ANKRD28	transfac_pro__M02022	MAFK (directAnnotation).
ANKRD28	transfac_pro__M06104	ZNF16 (directAnnotation).
ANKRD28	metacluster_161.1	HOXA9 (directAnnotation).
ANKRD28	transfac_pro__M06966	E4F1 (inferredBy_Orthology).
ANKRD28	transfac_pro__M05519	FEZF2 (inferredBy_Orthology).
ANKRD28	metacluster_52.5	HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2 (directAnnotation).
ANKRD28	transfac_pro__M06259	ZNF91 (directAnnotation).
ANKRD28	transfac_pro__M06180	ZNF445 (directAnnotation).
ANKRD28	transfac_pro__M05779	ZNF674 (directAnnotation).
ANKRD28	transfac_pro__M06518	ZNF383 (directAnnotation).
ANKRD28	metacluster_23.5	WT1 (directAnnotation).
ANKRD28	transfac_pro__M02898	SMAD3 (directAnnotation).
ANKRD28	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ANKRD28	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ANKRD28	hdpi__HIP2	UBE2K (directAnnotation).
ANKRD28	hdpi__NRL	NRL (directAnnotation).
ANKRD28	transfac_pro__M00430	E2F1 (directAnnotation).
ANKRD28	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ANKRD28	transfac_pro__M07329	SP7 (directAnnotation).
ANKRD28	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
ANKRD28	transfac_pro__M07397	ZNF148 (directAnnotation).
ANKRD28	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ANKRD28	cisbp__M07938	E2F1 (directAnnotation).
ANKRD28	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ANKRD28	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ANKRD28	transfac_pro__M07436	WT1 (directAnnotation).
ANKRD28	metacluster_3.14	WT1; WT1 (directAnnotation).
ANKRD28	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ANKRD28	transfac_pro__M01837	KLF11 (directAnnotation).
ANKRD28	transfac_pro__M07310	SP5 (directAnnotation).
ANKRD28	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ANKRD28	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ANKRD28	swissregulon__hs__KLF6	KLF6 (directAnnotation).
ANKRD28	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
ANKRD28	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ANKRD28	transfac_pro__M01175	ZBTB7B (directAnnotation).
ANKRD28	transfac_pro__M00716	ZBTB14 (directAnnotation).
ANKRD28	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ANKRD28	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ANKRD28	metacluster_163.2	ZNF682 (directAnnotation).
ANKRD28	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
ANKRD28	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
ANKRD28	transfac_pro__M00938	E2F1 (directAnnotation).
ANKRD28	transfac_pro__M02090	E2F4 (directAnnotation).
ANKRD28	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ANKRD28	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ANKRD28	transfac_pro__M01303	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."