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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WTAP

Summary for WTAP

Gene information	Gene symbol	WTAP
	Ensembl ID	ENSG00000146457
	Entrez ID	9589
	Gene name	WT1 associated protein
	Synonyms	KIAA0105\|MGC3925\|Mum2
	Gene type	protein_coding
	UniProtAcc	Q15007

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Dataset with differentially expressed gene: WTAP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.507826	1.40e-45
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.380535	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.403682	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.414311	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.656247	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.436482	1.22e-34
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.418318	2.18e-19
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.497601	2.36e-36

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Expression of WTAP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WTAP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
WTAP	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating WTAP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WTAP	hsa-miR-4666a-3p	97.9297	NM_152857
WTAP	hsa-miR-497-3p	97.2475	NM_152857
WTAP	hsa-miR-889-3p	96.3446	NM_001270532
WTAP	hsa-miR-550a-5p	93.9564	NM_152857
WTAP	hsa-miR-550a-3-5p	93.9564	NM_152857
WTAP	hsa-miR-1271-3p	93.9564	NM_152857
WTAP	hsa-miR-1225-3p	93.4737	NM_152857
WTAP	hsa-miR-124-3p	93.0548	NM_152857
WTAP	hsa-miR-506-3p	93.0548	NM_152857
WTAP	hsa-miR-196a-1-3p	92.4807	NM_001270531
WTAP	hsa-miR-586	92.409	NM_001270531
WTAP	hsa-miR-433-3p	92.3982	NM_001270532
WTAP	hsa-miR-139-5p	92.3401	NM_152857
WTAP	hsa-miR-5582-5p	92.0026	NM_152857
WTAP	hsa-miR-150-5p	91.721	NM_001270531
WTAP	hsa-miR-4504	91.2489	NM_001270531
WTAP	hsa-miR-548an	91.0661	NM_001270531
WTAP	hsa-miR-548aa	89.8867	NM_152857
WTAP	hsa-miR-548t-3p	89.8867	NM_152857
WTAP	hsa-miR-548ap-3p	89.8867	NM_152857
WTAP	hsa-miR-452-3p	88.5492	NM_152857
WTAP	hsa-miR-6768-3p	88.3292	NM_001270532
WTAP	hsa-miR-548c-3p	88.2994	NM_001270531
WTAP	hsa-miR-21-3p	87.3362	NM_152857
WTAP	hsa-miR-122b-3p	87.3362	NM_152857
WTAP	hsa-miR-1910-5p	87.1336	NM_152857
WTAP	hsa-miR-1227-3p	87.0831	NM_001270532
WTAP	hsa-miR-10523-5p	86.3977	NM_152857
WTAP	hsa-miR-7856-5p	86.2698	NM_001270531
WTAP	hsa-miR-3199	86.0891	NM_152857
WTAP	hsa-miR-8052	86.0891	NM_152857
WTAP	hsa-miR-4666a-5p	85.993	NM_152857
WTAP	hsa-miR-3618	85.9091	NM_152857
WTAP	hsa-miR-924	85.4681	NM_152857
WTAP	hsa-miR-3529-3p	84.8726	NM_001270531
WTAP	hsa-miR-627-5p	84.7374	NM_152857
WTAP	hsa-miR-4477b	84.4829	NM_001270531
WTAP	hsa-miR-606	84.33	NM_001270531
WTAP	hsa-miR-548p	82.9746	NM_001270531
WTAP	hsa-miR-548g-3p	82.9505	NM_001270531
WTAP	hsa-miR-758-3p	82.5568	NM_001270531
WTAP	hsa-miR-3119	82.3595	NM_152857
WTAP	hsa-miR-6820-5p	82.0857	NM_001270531
WTAP	hsa-miR-3973	81.5474	NM_001270531
WTAP	hsa-miR-3179	81.4695	NM_152857
WTAP	hsa-miR-7159-5p	81.4193	NM_001270532
WTAP	hsa-miR-1468-5p	81.4167	NM_152857
WTAP	hsa-miR-4775	81.2355	NM_001270532
WTAP	hsa-miR-4311	81.179	NM_001270531
WTAP	hsa-miR-1306-5p	81.1732	NM_152857

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Motifs and transcription factors (TFs) regulating WTAP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WTAP	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
WTAP	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
WTAP	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
WTAP	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
WTAP	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
WTAP	transfac_pro__M01298	MECP2 (directAnnotation).
WTAP	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
WTAP	transfac_pro__M00492	STAT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."