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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: USP15

Summary for USP15

Gene information	Gene symbol	USP15
	Ensembl ID	ENSG00000135655
	Entrez ID	9958
	Gene name	ubiquitin specific peptidase 15
	Synonyms	KIAA0529\|UNPH4
	Gene type	protein_coding
	UniProtAcc	Q9Y4E8

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Dataset with differentially expressed gene: USP15

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.311496	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.729025	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.292904	2.61e-07
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.25421	4.73e-26
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.311825	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.346517	6.60e-12
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.314893	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.340289	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.287221	6.80e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.359593	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.491188	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.256163	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.395148	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.559735	0.00e+00

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Expression of USP15 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to USP15

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating USP15

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
USP15	hsa-miR-545-3p	99.1494	NM_001252078
USP15	hsa-miR-5011-5p	98.9272	NM_006313
USP15	hsa-miR-3662	98.7573	NM_006313
USP15	hsa-miR-5692a	97.9461	NM_001252078
USP15	hsa-miR-586	97.1776	NM_001252078
USP15	hsa-miR-499b-5p	96.2565	NM_006313
USP15	hsa-miR-190a-3p	95.508	NM_001252078
USP15	hsa-miR-2113	95.4901	NM_006313
USP15	hsa-miR-5688	95.0364	NM_006313
USP15	hsa-miR-495-3p	94.8206	NM_006313
USP15	hsa-miR-548p	93.5645	NM_001252078
USP15	hsa-miR-105-5p	93.3008	NM_001252078
USP15	hsa-miR-7853-5p	93.3008	NM_001252078
USP15	hsa-miR-561-3p	92.9071	NM_006313
USP15	hsa-miR-4803	92.4568	NM_001252078
USP15	hsa-miR-135a-5p	92.3664	NM_001252078
USP15	hsa-miR-135b-5p	92.3664	NM_001252078
USP15	hsa-miR-6734-5p	92.0385	NM_001252079
USP15	hsa-miR-514a-5p	91.9296	NM_006313
USP15	hsa-miR-10522-5p	91.3951	NM_006313
USP15	hsa-miR-1297	91.3281	NM_001252078
USP15	hsa-miR-1193	90.8665	NM_001252079
USP15	hsa-miR-335-3p	90.6115	NM_001252079
USP15	hsa-miR-1277-5p	90.3588	NM_006313
USP15	hsa-miR-212-5p	89.9552	NM_001252079
USP15	hsa-miR-3145-3p	89.136	NM_006313
USP15	hsa-miR-548az-5p	88.987	NM_001252079
USP15	hsa-miR-548t-5p	88.987	NM_001252079
USP15	hsa-miR-6815-3p	88.9538	NM_001252078
USP15	hsa-miR-4652-3p	88.5382	NM_006313
USP15	hsa-miR-6768-3p	88.4527	NM_001252078
USP15	hsa-miR-337-3p	88.3694	NM_001252078
USP15	hsa-miR-15a-5p	88.2246	NM_001252078
USP15	hsa-miR-15b-5p	88.2246	NM_001252078
USP15	hsa-miR-195-5p	88.2246	NM_001252078
USP15	hsa-miR-16-5p	88.2246	NM_001252078
USP15	hsa-miR-6838-5p	88.2246	NM_001252078
USP15	hsa-miR-3646	87.9287	NM_006313
USP15	hsa-miR-424-5p	87.894	NM_001252078
USP15	hsa-miR-497-5p	87.894	NM_001252078
USP15	hsa-miR-548an	87.4997	NM_001252078
USP15	hsa-miR-889-3p	87.4793	NM_001252078
USP15	hsa-miR-509-3-5p	86.8725	NM_006313
USP15	hsa-miR-509-5p	86.8725	NM_006313
USP15	hsa-miR-217-5p	86.7316	NM_006313
USP15	hsa-miR-5580-3p	86.6614	NM_001252079
USP15	hsa-miR-4653-3p	86.4871	NM_001252079
USP15	hsa-miR-494-3p	86.3732	NM_001252078
USP15	hsa-miR-548m	86.084	NM_006313
USP15	hsa-miR-3163	85.812	NM_006313

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Motifs and transcription factors (TFs) regulating USP15

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
USP15	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
USP15	tfdimers__MD00151	CHURC1 (directAnnotation).
USP15	tfdimers__MD00391	KLF4 (directAnnotation).
USP15	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
USP15	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
USP15	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
USP15	metacluster_3.14	WT1; WT1 (directAnnotation).
USP15	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
USP15	transfac_public__M00491	PATZ1 (directAnnotation).
USP15	transfac_pro__M07397	ZNF148 (directAnnotation).
USP15	transfac_pro__M06629	ZNF578 (directAnnotation).
USP15	transfac_pro__M04706	RELA (directAnnotation).
USP15	transfac_pro__M06383	ZNF629 (inferredBy_Orthology).
USP15	transfac_pro__M06366	ZNF530 (directAnnotation).
USP15	hdpi__NRL	NRL (directAnnotation).
USP15	cisbp__M07938	E2F1 (directAnnotation).
USP15	transfac_pro__M00716	ZBTB14 (directAnnotation).
USP15	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
USP15	jaspar__MA1650.1	ZBTB14 (directAnnotation).
USP15	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
USP15	cisbp__M08228	PAX5 (directAnnotation).
USP15	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
USP15	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
USP15	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
USP15	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
USP15	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
USP15	transfac_pro__M02090	E2F4 (directAnnotation).
USP15	transfac_pro__M03846	SMAD5 (directAnnotation).
USP15	metacluster_45.4	E2F2 (directAnnotation).
USP15	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
USP15	hdpi__FEZF2	FEZF2 (directAnnotation).
USP15	cisbp__M00343	PAX6 (directAnnotation).
USP15	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
USP15	transfac_pro__M12694	ZFP14 (directAnnotation).
USP15	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
USP15	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
USP15	swissregulon__hs__KLF6	KLF6 (directAnnotation).
USP15	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
USP15	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
USP15	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
USP15	hdpi__GTF3C2	GTF3C2 (directAnnotation).
USP15	transfac_pro__M08005	TCFL5 (inferredBy_Orthology).
USP15	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
USP15	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
USP15	transfac_pro__M03876	ZBTB33 (directAnnotation).
USP15	transfac_pro__M04646	FOXN4 (directAnnotation).
USP15	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
USP15	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
USP15	transfac_pro__M04617	ZBTB7A (directAnnotation).
USP15	transfac_pro__M07436	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."