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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMPO

Summary for TMPO

Gene information	Gene symbol	TMPO
	Ensembl ID	ENSG00000120802
	Entrez ID	7112
	Gene name	thymopoietin
	Synonyms	LAP2\|LEMD4\|TP
	Gene type	protein_coding
	UniProtAcc	P42167

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Dataset with differentially expressed gene: TMPO

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.293718	1.48e-10
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.273736	1.06e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.268125	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.312413	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.252875	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.460198	2.65e-27
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.440096	3.90e-22
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.265692	3.34e-06
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.598844	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.677007	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.312522	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.325	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.52325	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.26679	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.304646	1.16e-15
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.345014	1.60e-12
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.483339	4.20e-28
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.354523	1.02e-13
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.383027	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.40887	0.00e+00

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Expression of TMPO in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TMPO

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TMPO

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMPO	hsa-miR-23b-3p	99.3204	NM_001032283
TMPO	hsa-miR-23c	99.3204	NM_001032283
TMPO	hsa-miR-23a-3p	99.3204	NM_001032283
TMPO	hsa-miR-1305	98.8188	NM_001032283
TMPO	hsa-miR-4666a-5p	97.3087	NM_001032283
TMPO	hsa-miR-12123	97.0448	NM_001032283
TMPO	hsa-miR-183-5p	96.8046	NM_001032283
TMPO	hsa-miR-5003-3p	95.9777	NM_001032283
TMPO	hsa-miR-1537-5p	94.7578	NM_001032283
TMPO	hsa-miR-1251-3p	94.4136	NM_001032283
TMPO	hsa-miR-12131	94.2016	NM_003276
TMPO	hsa-miR-4291	93.3117	NM_001032283
TMPO	hsa-miR-570-3p	93.0915	NM_003276
TMPO	hsa-miR-3663-5p	92.7531	NM_001032283
TMPO	hsa-miR-4531	92.0218	NM_003276
TMPO	hsa-miR-4307	91.9174	NM_001032283
TMPO	hsa-miR-137-3p	90.713	NM_001032283
TMPO	hsa-miR-3919	89.9574	NM_001032283
TMPO	hsa-miR-3613-3p	89.7066	NM_001032283
TMPO	hsa-miR-576-5p	89.6378	NM_001032283
TMPO	hsa-miR-190a-3p	89.1077	NM_001032283
TMPO	hsa-miR-153-5p	88.7841	NM_001032283
TMPO	hsa-miR-5584-3p	88.7595	NM_001032283
TMPO	hsa-miR-12135	88.4295	NM_001032283
TMPO	hsa-miR-1273h-3p	88.398	NM_003276
TMPO	hsa-miR-421	88.0606	NM_001032283
TMPO	hsa-miR-6131	87.5944	NM_001032283
TMPO	hsa-miR-520f-5p	87.314	NM_001032283
TMPO	hsa-miR-1283	87.1437	NM_001032283
TMPO	hsa-miR-183-3p	86.9675	NM_001032283
TMPO	hsa-miR-139-5p	86.6932	NM_003276
TMPO	hsa-miR-12136	86.4927	NM_001032283
TMPO	hsa-miR-338-5p	86.382	NM_003276
TMPO	hsa-miR-3692-3p	86.3593	NM_003276
TMPO	hsa-miR-4711-3p	85.4496	NM_001032283
TMPO	hsa-miR-943	85.3584	NM_001032283
TMPO	hsa-miR-6881-3p	85.3262	NM_001032283
TMPO	hsa-miR-3619-3p	85.2998	NM_001032283
TMPO	hsa-miR-648	85.2752	NM_001032283
TMPO	hsa-miR-6728-3p	85.1183	NM_001032283
TMPO	hsa-miR-759	84.9362	NM_003276
TMPO	hsa-miR-4711-5p	84.9275	NM_003276
TMPO	hsa-miR-6516-5p	84.9049	NM_001032283
TMPO	hsa-miR-4795-3p	84.5881	NM_001032283
TMPO	hsa-miR-6885-3p	83.9093	NM_001032283
TMPO	hsa-miR-4478	83.8314	NM_001032283
TMPO	hsa-miR-215-5p	83.5052	NM_003276
TMPO	hsa-miR-192-5p	83.5052	NM_003276
TMPO	hsa-miR-5007-5p	83.4108	NM_003276
TMPO	hsa-miR-548n	83.0847	NM_003276

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Motifs and transcription factors (TFs) regulating TMPO

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMPO	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
TMPO	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
TMPO	transfac_pro__M02089	E2F3 (directAnnotation).
TMPO	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TMPO	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
TMPO	transfac_pro__M04817	ZBTB33 (directAnnotation).
TMPO	tfdimers__MD00483	ZBTB14 (directAnnotation).
TMPO	transfac_pro__M07317	CTBP1 (directAnnotation).
TMPO	transfac_pro__M00716	ZBTB14 (directAnnotation).
TMPO	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
TMPO	transfac_pro__M04893	TAF1 (directAnnotation).
TMPO	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
TMPO	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
TMPO	transfac_pro__M04916	TAF1 (directAnnotation).
TMPO	hdpi__RARA	RARA (directAnnotation).
TMPO	jaspar__MA1650.1	ZBTB14 (directAnnotation).
TMPO	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
TMPO	cisbp__M08228	PAX5 (directAnnotation).
TMPO	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
TMPO	transfac_pro__M00938	E2F1 (directAnnotation).
TMPO	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
TMPO	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TMPO	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
TMPO	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TMPO	cisbp__M00788	ZFY (inferredBy_Orthology).
TMPO	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
TMPO	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
TMPO	transfac_pro__M02090	E2F4 (directAnnotation).
TMPO	transfac_pro__M03846	SMAD5 (directAnnotation).
TMPO	metacluster_45.4	E2F2 (directAnnotation).
TMPO	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TMPO	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
TMPO	metacluster_175.1	ZNF283 (directAnnotation).
TMPO	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
TMPO	cisbp__M00343	PAX6 (directAnnotation).
TMPO	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TMPO	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
TMPO	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
TMPO	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TMPO	transfac_pro__M12694	ZFP14 (directAnnotation).
TMPO	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
TMPO	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
TMPO	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
TMPO	swissregulon__hs__KLF6	KLF6 (directAnnotation).
TMPO	transfac_pro__M02898	SMAD3 (directAnnotation).
TMPO	transfac_pro__M07387	ZBTB7A (directAnnotation).
TMPO	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
TMPO	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
TMPO	transfac_pro__M00430	E2F1 (directAnnotation).
TMPO	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."