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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ROCK1

Summary for ROCK1

Gene information	Gene symbol	ROCK1
	Ensembl ID	ENSG00000067900
	Entrez ID	6093
	Gene name	Rho associated coiled-coil containing protein kinase 1
	Synonyms	p160ROCK
	Gene type	protein_coding
	UniProtAcc	Q13464

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Dataset with differentially expressed gene: ROCK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.287178	1.03e-13
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.345319	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.297337	2.30e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.27408	1.31e-39
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.337463	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.30979	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.276906	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.649394	7.08e-03
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.539379	0.00e+00

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Expression of ROCK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ROCK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ROCK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ROCK1	hsa-miR-6516-5p	97.3021	NM_005406
ROCK1	hsa-miR-153-3p	96.7768	NM_005406
ROCK1	hsa-miR-494-3p	96.5809	NM_005406
ROCK1	hsa-miR-4422	96.3739	NM_005406
ROCK1	hsa-miR-6811-3p	95.7434	NM_005406
ROCK1	hsa-miR-4666a-3p	95.5079	NM_005406
ROCK1	hsa-miR-124-3p	93.0791	NM_005406
ROCK1	hsa-miR-506-3p	93.0791	NM_005406
ROCK1	hsa-miR-599	92.1836	NM_005406
ROCK1	hsa-miR-550b-3p	91.8367	NM_005406
ROCK1	hsa-miR-3119	91.6529	NM_005406
ROCK1	hsa-miR-202-5p	91.6028	NM_005406
ROCK1	hsa-miR-545-5p	91.5535	NM_005406
ROCK1	hsa-miR-144-3p	90.936	NM_005406
ROCK1	hsa-miR-9983-3p	90.4485	NM_005406
ROCK1	hsa-let-7a-3p	90.1391	NM_005406
ROCK1	hsa-let-7b-3p	90.1391	NM_005406
ROCK1	hsa-miR-98-3p	90.1391	NM_005406
ROCK1	hsa-let-7f-1-3p	90.1391	NM_005406
ROCK1	hsa-miR-4255	89.8617	NM_005406
ROCK1	hsa-miR-4470	89.809	NM_005406
ROCK1	hsa-miR-16-1-3p	89.5081	NM_005406
ROCK1	hsa-miR-592	88.9092	NM_005406
ROCK1	hsa-miR-5002-5p	88.5614	NM_005406
ROCK1	hsa-miR-3194-3p	88.2885	NM_005406
ROCK1	hsa-miR-5700	87.9678	NM_005406
ROCK1	hsa-miR-202-3p	87.6114	NM_005406
ROCK1	hsa-let-7a-2-3p	87.2412	NM_005406
ROCK1	hsa-let-7g-3p	87.2412	NM_005406
ROCK1	hsa-miR-139-5p	86.8508	NM_005406
ROCK1	hsa-miR-3065-3p	86.8393	NM_005406
ROCK1	hsa-miR-1825	86.3867	NM_005406
ROCK1	hsa-miR-3157-5p	85.6603	NM_005406
ROCK1	hsa-miR-6758-3p	85.6148	NM_005406
ROCK1	hsa-miR-148b-3p	84.6531	NM_005406
ROCK1	hsa-miR-148a-3p	84.6531	NM_005406
ROCK1	hsa-miR-152-3p	84.6531	NM_005406
ROCK1	hsa-miR-190b-5p	83.8798	NM_005406
ROCK1	hsa-miR-190a-5p	83.8798	NM_005406
ROCK1	hsa-miR-372-5p	83.616	NM_005406
ROCK1	hsa-miR-7151-5p	83.5576	NM_005406
ROCK1	hsa-miR-6507-5p	83.551	NM_005406
ROCK1	hsa-miR-135b-5p	83.2209	NM_005406
ROCK1	hsa-miR-135a-5p	83.2209	NM_005406
ROCK1	hsa-miR-325	83.1662	NM_005406
ROCK1	hsa-miR-4307	83.109	NM_005406
ROCK1	hsa-miR-3689f	82.0736	NM_005406
ROCK1	hsa-miR-1255b-2-3p	80.9004	NM_005406
ROCK1	hsa-miR-4302	80.7671	NM_005406
ROCK1	hsa-miR-3714	80.4682	NM_005406

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Motifs and transcription factors (TFs) regulating ROCK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ROCK1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ROCK1	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
ROCK1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ROCK1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ROCK1	transfac_pro__M07329	SP7 (directAnnotation).
ROCK1	transfac_pro__M04617	ZBTB7A (directAnnotation).
ROCK1	transfac_pro__M01858	TFAP2B (directAnnotation).
ROCK1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
ROCK1	transfac_pro__M06331	ZNF343 (directAnnotation).
ROCK1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ROCK1	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
ROCK1	tfdimers__MD00167	HIC1; MAFA (directAnnotation).
ROCK1	cisbp__M01733	CCDC169-SOHLH2; SOHLH2 (inferredBy_Orthology).
ROCK1	transfac_pro__M12634	ZBTB17 (directAnnotation).
ROCK1	transfac_public__M00005	TFAP4 (directAnnotation).
ROCK1	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
ROCK1	metacluster_154.2	PAX1; PAX2; PAX2; PAX2; PAX2; PAX4; PAX4; PAX4; PAX4; PAX4; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX8; PAX8; PAX9 (directAnnotation). PAX1; PAX1; PAX1; PAX5; PAX6; PAX6 (inferredBy_Orthology).
ROCK1	jaspar__MA0131.2	HINFP (directAnnotation).
ROCK1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
ROCK1	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
ROCK1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ROCK1	transfac_pro__M07437	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ROCK1	"(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE"	DB07876	small molecule
ROCK1	"Belumosudil"	DB16703	small molecule
ROCK1	"Fasudil"	DB08162	small molecule
ROCK1	"Hydroxyfasudil"	DB04707	small molecule
ROCK1	"Netarsudil"	DB13931	small molecule
ROCK1	"Ripasudil"	DB13165	small molecule
ROCK1	"Y-27632"	DB08756	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."