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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAD21

Summary for RAD21

Gene information	Gene symbol	RAD21
	Ensembl ID	ENSG00000164754
	Entrez ID	5885
	Gene name	RAD21 cohesin complex component
	Synonyms	hHR21\|KIAA0078\|SCC1
	Gene type	protein_coding
	UniProtAcc	O60216

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Dataset with differentially expressed gene: RAD21

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.437447	6.07e-32
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.412403	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.289994	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.314229	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.30638	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.354713	2.84e-14
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.434929	5.50e-19
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.346711	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.510565	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.283624	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.330355	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.307944	7.07e-34
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.328926	1.90e-42
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.272999	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.751488	0.00e+00

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Expression of RAD21 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAD21

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAD21

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAD21	hsa-miR-3148	97.2173	NM_006265
RAD21	hsa-miR-18b-3p	96.0664	NM_006265
RAD21	hsa-miR-3157-3p	95.8607	NM_006265
RAD21	hsa-miR-1305	95.6903	NM_006265
RAD21	hsa-miR-7151-3p	95.5674	NM_006265
RAD21	hsa-miR-548at-5p	95.527	NM_006265
RAD21	hsa-miR-3944-5p	95.4856	NM_006265
RAD21	hsa-miR-6715b-5p	95.054	NM_006265
RAD21	hsa-miR-4269	95.054	NM_006265
RAD21	hsa-let-7f-1-3p	93.9709	NM_006265
RAD21	hsa-let-7b-3p	93.9709	NM_006265
RAD21	hsa-let-7a-3p	93.9709	NM_006265
RAD21	hsa-miR-98-3p	93.9709	NM_006265
RAD21	hsa-miR-4775	93.4356	NM_006265
RAD21	hsa-miR-4719	93.3988	NM_006265
RAD21	hsa-miR-5582-3p	91.8386	NM_006265
RAD21	hsa-miR-4275	91.592	NM_006265
RAD21	hsa-miR-4704-5p	91.5124	NM_006265
RAD21	hsa-let-7a-2-3p	91.4795	NM_006265
RAD21	hsa-let-7g-3p	91.4795	NM_006265
RAD21	hsa-miR-23a-3p	91.0117	NM_006265
RAD21	hsa-miR-23b-3p	91.0117	NM_006265
RAD21	hsa-miR-23c	91.0117	NM_006265
RAD21	hsa-miR-12136	90.287	NM_006265
RAD21	hsa-miR-4661-5p	90.1505	NM_006265
RAD21	hsa-miR-888-5p	89.59	NM_006265
RAD21	hsa-miR-32-5p	89.2898	NM_006265
RAD21	hsa-miR-92b-3p	89.2898	NM_006265
RAD21	hsa-miR-92a-3p	89.2898	NM_006265
RAD21	hsa-miR-548c-3p	88.7759	NM_006265
RAD21	hsa-miR-4789-5p	88.771	NM_006265
RAD21	hsa-miR-5006-3p	88.6801	NM_006265
RAD21	hsa-miR-4755-5p	88.6801	NM_006265
RAD21	hsa-miR-590-3p	88.271	NM_006265
RAD21	hsa-miR-875-3p	87.1514	NM_006265
RAD21	hsa-miR-1264	86.7195	NM_006265
RAD21	hsa-miR-1243	86.691	NM_006265
RAD21	hsa-miR-4738-3p	85.9807	NM_006265
RAD21	hsa-miR-7107-3p	85.875	NM_006265
RAD21	hsa-miR-6753-3p	85.875	NM_006265
RAD21	hsa-miR-1279	85.5764	NM_006265
RAD21	hsa-miR-3609	85.3891	NM_006265
RAD21	hsa-miR-548ah-5p	85.3891	NM_006265
RAD21	hsa-miR-25-3p	85.3748	NM_006265
RAD21	hsa-miR-367-3p	85.3748	NM_006265
RAD21	hsa-miR-363-3p	85.3748	NM_006265
RAD21	hsa-miR-433-3p	85.1827	NM_006265
RAD21	hsa-miR-6831-3p	85.0454	NM_006265
RAD21	hsa-miR-15b-3p	84.6838	NM_006265
RAD21	hsa-miR-493-5p	84.585	NM_006265

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Motifs and transcription factors (TFs) regulating RAD21

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAD21	cisbp__M00808	MYPOP (inferredBy_Orthology).
RAD21	transfac_pro__M05529	ZBTB5 (inferredBy_Orthology).
RAD21	transfac_pro__M06432	ZNF571 (directAnnotation).
RAD21	hdpi__MLX	MLX (directAnnotation).
RAD21	taipale_tf_pairs__FOXJ3_ELF1_NNARAAAACCGAAWMN_CAP	ELF1; FOXJ3 (directAnnotation).
RAD21	transfac_pro__M06415	ZNF429 (directAnnotation).
RAD21	taipale_tf_pairs__MYBL1_EOMES_NNSYGNCNAACNNNNNNCACRCNN_CAP_repr	EOMES; MYBL1 (directAnnotation).
RAD21	hocomoco__E2F8_HUMAN.H11MO.0.D	E2F8 (directAnnotation).
RAD21	transfac_pro__M05731	ZNF660 (directAnnotation).
RAD21	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
RAD21	transfac_pro__M06035	ZNF749 (directAnnotation).
RAD21	cisbp__M07938	E2F1 (directAnnotation).
RAD21	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
RAD21	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
RAD21	transfac_pro__M02090	E2F4 (directAnnotation).
RAD21	transfac_pro__M06229	ZNF91 (directAnnotation).
RAD21	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
RAD21	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
RAD21	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RAD21	metacluster_163.2	ZNF682 (directAnnotation).
RAD21	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RAD21	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
RAD21	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
RAD21	transfac_pro__M06463	ZNF595 (directAnnotation).
RAD21	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
RAD21	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RAD21	jaspar__MA0597.2	THAP1 (directAnnotation).
RAD21	jaspar__MA1596.1	ZNF460 (directAnnotation).
RAD21	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
RAD21	transfac_pro__M04817	ZBTB33 (directAnnotation).
RAD21	hdpi__NRL	NRL (directAnnotation).
RAD21	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RAD21	hdpi__FEZF2	FEZF2 (directAnnotation).
RAD21	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
RAD21	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RAD21	metacluster_155.11	SPZ1 (directAnnotation).
RAD21	hdpi__HTATIP2	HTATIP2 (directAnnotation).
RAD21	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
RAD21	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
RAD21	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
RAD21	tfdimers__MD00483	ZBTB14 (directAnnotation).
RAD21	transfac_pro__M07317	CTBP1 (directAnnotation).
RAD21	transfac_pro__M03806	ZBTB7C (directAnnotation).
RAD21	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
RAD21	transfac_pro__M01783	SP2 (directAnnotation).
RAD21	transfac_pro__M04916	TAF1 (directAnnotation).
RAD21	hdpi__RARA	RARA (directAnnotation).
RAD21	jaspar__MA1650.1	ZBTB14 (directAnnotation).
RAD21	cisbp__M08228	PAX5 (directAnnotation).
RAD21	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."