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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PTBP3

Summary for PTBP3

Gene information	Gene symbol	PTBP3
	Ensembl ID	ENSG00000119314
	Entrez ID	9991
	Gene name	polypyrimidine tract binding protein 3
	Synonyms	DKFZp781I1117\|ROD1
	Gene type	protein_coding
	UniProtAcc	O95758

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Dataset with differentially expressed gene: PTBP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.356443	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.290309	1.23e-40
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.298273	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.278439	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.271223	1.11e-09
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.254099	6.93e-08
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.260892	6.01e-26
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.777753	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.501201	5.02e-15

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Expression of PTBP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PTBP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PTBP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTBP3	hsa-miR-548t-3p	99.8415	NM_001163788
PTBP3	hsa-miR-548ap-3p	99.8415	NM_001163788
PTBP3	hsa-miR-548aa	99.8415	NM_001163788
PTBP3	hsa-miR-4282	99.6986	NM_001244898
PTBP3	hsa-miR-590-3p	99.6943	NM_001163788
PTBP3	hsa-miR-12136	99.5301	NM_001163788
PTBP3	hsa-miR-6124	99.3477	NM_001163788
PTBP3	hsa-miR-4775	99.2332	NM_001163788
PTBP3	hsa-miR-6768-3p	99.0617	NM_001163788
PTBP3	hsa-miR-506-3p	98.8178	NM_001163788
PTBP3	hsa-miR-124-3p	98.8178	NM_001163788
PTBP3	hsa-miR-570-3p	98.796	NM_001163788
PTBP3	hsa-miR-548aj-3p	98.7333	NM_001244898
PTBP3	hsa-miR-548x-3p	98.7333	NM_001244898
PTBP3	hsa-miR-4262	98.4025	NM_001163788
PTBP3	hsa-miR-3671	98.2194	NM_001163788
PTBP3	hsa-miR-497-3p	98.2096	NM_001163788
PTBP3	hsa-miR-300	98.2013	NM_001163788
PTBP3	hsa-miR-381-3p	98.2013	NM_001163788
PTBP3	hsa-miR-181c-5p	98.182	NM_001163788
PTBP3	hsa-miR-181d-5p	98.182	NM_001163788
PTBP3	hsa-miR-181b-5p	98.182	NM_001163788
PTBP3	hsa-miR-181a-5p	98.182	NM_001163788
PTBP3	hsa-miR-548am-3p	98.1504	NM_001244898
PTBP3	hsa-miR-548ae-3p	98.1504	NM_001244898
PTBP3	hsa-miR-548j-3p	98.1504	NM_001244898
PTBP3	hsa-miR-548aq-3p	98.1504	NM_001244898
PTBP3	hsa-miR-548ah-3p	98.1504	NM_001244898
PTBP3	hsa-miR-3140-5p	98.1323	NM_001163788
PTBP3	hsa-miR-4482-3p	98.0701	NM_001244898
PTBP3	hsa-miR-8485	97.9492	NM_001163788
PTBP3	hsa-miR-3163	97.923	NM_001163788
PTBP3	hsa-miR-4666a-3p	97.8758	NM_001163788
PTBP3	hsa-miR-548an	97.3759	NM_001244897
PTBP3	hsa-miR-8054	97.075	NM_001163788
PTBP3	hsa-miR-548av-5p	97.075	NM_001163788
PTBP3	hsa-miR-548k	97.075	NM_001163788
PTBP3	hsa-miR-5584-5p	97.0022	NM_001163788
PTBP3	hsa-miR-5582-5p	96.9689	NM_001163788
PTBP3	hsa-miR-607	96.8975	NM_001163788
PTBP3	hsa-miR-26a-1-3p	96.8828	NM_001163788
PTBP3	hsa-miR-26a-2-3p	96.8828	NM_001163788
PTBP3	hsa-miR-4672	96.7912	NM_001163788
PTBP3	hsa-miR-548as-3p	96.7132	NM_001163788
PTBP3	hsa-miR-4762-5p	96.6718	NM_001163788
PTBP3	hsa-miR-548z	96.5717	NM_001163788
PTBP3	hsa-miR-548bb-3p	96.5717	NM_001163788
PTBP3	hsa-miR-548h-3p	96.5717	NM_001163788
PTBP3	hsa-miR-4521	96.5681	NM_001244897
PTBP3	hsa-miR-548d-3p	96.4425	NM_001163788

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Motifs and transcription factors (TFs) regulating PTBP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTBP3	cisbp__M01733	CCDC169-SOHLH2; SOHLH2 (inferredBy_Orthology).
PTBP3	transfac_public__M00005	TFAP4 (directAnnotation).
PTBP3	metacluster_154.2	PAX1; PAX2; PAX2; PAX2; PAX2; PAX4; PAX4; PAX4; PAX4; PAX4; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX8; PAX8; PAX9 (directAnnotation). PAX1; PAX1; PAX1; PAX5; PAX6; PAX6 (inferredBy_Orthology).
PTBP3	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
PTBP3	jaspar__MA0131.2	HINFP (directAnnotation).
PTBP3	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
PTBP3	transfac_pro__M07437	ZBTB2 (directAnnotation).
PTBP3	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
PTBP3	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."