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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PAK2

Summary for PAK2

Gene information	Gene symbol	PAK2
	Ensembl ID	ENSG00000180370
	Entrez ID	5062
	Gene name	p21 (RAC1) activated kinase 2
	Synonyms	PAK65\|PAKgamma
	Gene type	protein_coding
	UniProtAcc	Q13177

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Dataset with differentially expressed gene: PAK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.425532	4.05e-38
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.288398	2.42e-06
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.260248	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.280164	3.31e-03
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.259802	1.80e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.331409	8.46e-11
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.396106	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.78398	1.30e-04
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.32513	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.296258	4.45e-14

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Expression of PAK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PAK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PAK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PAK2	hsa-miR-3148	99.6388	NM_002577
PAK2	hsa-miR-6809-3p	99.0199	NM_002577
PAK2	hsa-miR-4482-3p	99.0064	NM_002577
PAK2	hsa-miR-6771-3p	97.6441	NM_002577
PAK2	hsa-miR-511-5p	97.4829	NM_002577
PAK2	hsa-miR-3688-3p	97.4818	NM_002577
PAK2	hsa-miR-4753-3p	97.4291	NM_002577
PAK2	hsa-miR-335-3p	97.333	NM_002577
PAK2	hsa-miR-3163	96.8444	NM_002577
PAK2	hsa-miR-548c-3p	96.7336	NM_002577
PAK2	hsa-miR-6817-5p	95.5455	NM_002577
PAK2	hsa-miR-4769-3p	95.5455	NM_002577
PAK2	hsa-miR-103a-2-5p	94.5854	NM_002577
PAK2	hsa-miR-9500	94.3814	NM_002577
PAK2	hsa-miR-1297	94.0568	NM_002577
PAK2	hsa-miR-7159-3p	94.0244	NM_002577
PAK2	hsa-miR-26b-5p	93.5022	NM_002577
PAK2	hsa-miR-26a-5p	93.5022	NM_002577
PAK2	hsa-miR-103a-1-5p	93.4715	NM_002577
PAK2	hsa-miR-4282	92.9721	NM_002577
PAK2	hsa-miR-4465	92.6876	NM_002577
PAK2	hsa-miR-23c	92.5965	NM_002577
PAK2	hsa-miR-23b-3p	92.5965	NM_002577
PAK2	hsa-miR-23a-3p	92.5965	NM_002577
PAK2	hsa-miR-548ar-3p	92.5308	NM_002577
PAK2	hsa-miR-10523-5p	92.2168	NM_002577
PAK2	hsa-miR-4514	92.0924	NM_002577
PAK2	hsa-miR-3617-5p	91.7207	NM_002577
PAK2	hsa-miR-641	91.7207	NM_002577
PAK2	hsa-let-7b-3p	91.385	NM_002577
PAK2	hsa-miR-98-3p	91.385	NM_002577
PAK2	hsa-let-7a-3p	91.385	NM_002577
PAK2	hsa-let-7f-1-3p	91.385	NM_002577
PAK2	hsa-miR-1202	91.3169	NM_002577
PAK2	hsa-miR-3972	91.3169	NM_002577
PAK2	hsa-miR-548a-3p	91.2731	NM_002577
PAK2	hsa-miR-548bc	91.2731	NM_002577
PAK2	hsa-miR-548e-3p	91.2731	NM_002577
PAK2	hsa-miR-548f-3p	91.2731	NM_002577
PAK2	hsa-miR-548az-3p	91.2731	NM_002577
PAK2	hsa-miR-548an	91.2268	NM_002577
PAK2	hsa-miR-5007-3p	91.169	NM_002577
PAK2	hsa-miR-12113	91.1634	NM_002577
PAK2	hsa-miR-4539	90.5174	NM_002577
PAK2	hsa-miR-711	90.1756	NM_002577
PAK2	hsa-miR-1291	89.605	NM_002577
PAK2	hsa-miR-4694-3p	89.4626	NM_002577
PAK2	hsa-miR-6866-5p	89.0402	NM_002577
PAK2	hsa-miR-1185-1-3p	88.963	NM_002577
PAK2	hsa-let-7f-2-3p	88.963	NM_002577

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Motifs and transcription factors (TFs) regulating PAK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PAK2	transfac_pro__M03821	ESR2 (directAnnotation).
PAK2	metacluster_102.2	ZBED1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PAK2	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."