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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: MGAT4A

Summary for MGAT4A

Gene informationGene symbol

MGAT4A

Ensembl ID

ENSG00000071073

Entrez ID

11320

Gene namealpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
SynonymsGnT-4a|GnT-Iva
Gene typeprotein_coding
UniProtAcc

Q9UM21


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Dataset with differentially expressed gene: MGAT4A

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreNK cells0.2854580.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD4+ T cells0.3138590.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)postCD8+ T cells-0.2628730.00e+00

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNACD8+ T cells0.4177111.33e-13

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAMono/Macro-0.2945562.59e-14

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMono/Macro0.3137825.67e-04

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells-0.2647360.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD4+ T cells-0.4335250.00e+00

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Expression of MGAT4A in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to MGAT4A

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MGAT4A

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
MGAT4Ahsa-miR-60799.8171NM_012214
MGAT4Ahsa-miR-548n99.76NM_012214
MGAT4Ahsa-miR-190a-3p99.3182NM_012214
MGAT4Ahsa-miR-4477b99.2308NM_012214
MGAT4Ahsa-miR-7856-5p99.1363NM_012214
MGAT4Ahsa-miR-15b-5p98.8555NM_001160154
MGAT4Ahsa-miR-15a-5p98.8555NM_001160154
MGAT4Ahsa-miR-195-5p98.8555NM_001160154
MGAT4Ahsa-miR-16-5p98.8555NM_001160154
MGAT4Ahsa-miR-34a-5p98.5719NM_012214
MGAT4Ahsa-miR-449a98.5719NM_012214
MGAT4Ahsa-miR-34c-5p98.237NM_012214
MGAT4Ahsa-miR-449b-5p98.237NM_012214
MGAT4Ahsa-miR-497-5p98.1617NM_001160154
MGAT4Ahsa-miR-424-5p98.1617NM_001160154
MGAT4Ahsa-miR-6838-5p98.1617NM_001160154
MGAT4Ahsa-miR-60398.1559NM_012214
MGAT4Ahsa-miR-5011-5p98.1115NM_012214
MGAT4Ahsa-miR-5692a98.0078NM_012214
MGAT4Ahsa-miR-425597.9685NM_012214
MGAT4Ahsa-miR-64697.8088NM_012214
MGAT4Ahsa-miR-411-3p97.7501NM_012214
MGAT4Ahsa-miR-379-3p97.7501NM_012214
MGAT4Ahsa-miR-313397.5195NM_012214
MGAT4Ahsa-miR-367197.495NM_012214
MGAT4Ahsa-miR-503-5p97.4777NM_012214
MGAT4Ahsa-miR-101-3p97.408NM_012214
MGAT4Ahsa-miR-4524b-5p97.3917NM_012214
MGAT4Ahsa-miR-4524a-5p97.3917NM_012214
MGAT4Ahsa-miR-548av-5p97.2131NM_012214
MGAT4Ahsa-miR-548k97.2131NM_012214
MGAT4Ahsa-miR-805497.2131NM_012214
MGAT4Ahsa-miR-6768-5p97.0608NM_012214
MGAT4Ahsa-miR-144-3p96.9369NM_012214
MGAT4Ahsa-miR-365896.2763NM_012214
MGAT4Ahsa-miR-372-5p96.1452NM_012214
MGAT4Ahsa-miR-153-5p96.1267NM_012214
MGAT4Ahsa-miR-5197-5p96.0123NM_012214
MGAT4Ahsa-miR-3613-3p95.6707NM_012214
MGAT4Ahsa-miR-314895.5321NM_012214
MGAT4Ahsa-miR-651-3p95.4398NM_012214
MGAT4Ahsa-miR-369-3p95.0972NM_012214
MGAT4Ahsa-miR-576-5p94.7668NM_012214
MGAT4Ahsa-miR-467294.3981NM_012214
MGAT4Ahsa-miR-139-5p94.3428NM_012214
MGAT4Ahsa-miR-6882-5p94.3047NM_012214
MGAT4Ahsa-miR-24-3p94.2833NM_012214
MGAT4Ahsa-miR-392494.2098NM_012214
MGAT4Ahsa-miR-391994.1729NM_012214
MGAT4Ahsa-miR-1212493.5194NM_012214
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Motifs and transcription factors (TFs) regulating MGAT4A

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
MGAT4Atransfac_pro__M04646FOXN4 (directAnnotation).
MGAT4Ametacluster_126.2ZBTB4; ZBTB4 (directAnnotation).
MGAT4Akznf__ZBTB14_Schmitges2016_RCADEZBTB14 (directAnnotation).
MGAT4Ataipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_reprE2F1; ELK1 (directAnnotation).
MGAT4Atransfac_pro__M04617ZBTB7A (directAnnotation).
MGAT4Atransfac_pro__M07436WT1 (directAnnotation).
MGAT4Atransfac_pro__M01858TFAP2B (directAnnotation).
MGAT4Ametacluster_66.4ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
MGAT4Ametacluster_135.11NR2C2 (directAnnotation).
MGAT4Atransfac_pro__M07437ZBTB2 (directAnnotation).
MGAT4Atransfac_pro__M05605GATA6 (inferredBy_Orthology).
MGAT4Ametacluster_62.3HSF5 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."