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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LBR

Summary for LBR

Gene information	Gene symbol	LBR
	Ensembl ID	ENSG00000143815
	Entrez ID	3930
	Gene name	lamin B receptor
	Synonyms	DHCR14B\|TDRD18
	Gene type	protein_coding
	UniProtAcc	Q14739

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Dataset with differentially expressed gene: LBR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.288271	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.322224	1.20e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.250342	3.08e-38
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.256359	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.739266	4.20e-45
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.316717	1.25e-12
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.413981	6.64e-07
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.47513	9.54e-18
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.579137	7.19e-18
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.380126	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.572656	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.307211	4.20e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.65153	1.48e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.579808	9.01e-36

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Expression of LBR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LBR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LBR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LBR	hsa-miR-6838-3p	98.3971	NM_194442
LBR	hsa-miR-548p	96.7701	NM_002296
LBR	hsa-miR-202-5p	96.5977	NM_194442
LBR	hsa-miR-1284	94.3174	NM_194442
LBR	hsa-miR-3163	93.923	NM_002296
LBR	hsa-miR-152-3p	93.3481	NM_002296
LBR	hsa-miR-148a-3p	93.3481	NM_002296
LBR	hsa-miR-148b-3p	93.3481	NM_002296
LBR	hsa-miR-3613-3p	92.47	NM_002296
LBR	hsa-miR-429	91.4696	NM_002296
LBR	hsa-miR-200c-3p	91.4696	NM_002296
LBR	hsa-miR-200b-3p	91.4696	NM_002296
LBR	hsa-miR-548av-3p	91.2678	NM_002296
LBR	hsa-miR-1305	90.6003	NM_194442
LBR	hsa-miR-450b-5p	90.3585	NM_002296
LBR	hsa-miR-10393-5p	90.2129	NM_002296
LBR	hsa-let-7b-5p	88.7336	NM_002296
LBR	hsa-let-7c-5p	88.7336	NM_002296
LBR	hsa-let-7a-5p	88.7336	NM_002296
LBR	hsa-let-7g-5p	88.7336	NM_002296
LBR	hsa-let-7e-5p	88.7336	NM_002296
LBR	hsa-let-7f-5p	88.7336	NM_002296
LBR	hsa-miR-98-5p	88.7336	NM_002296
LBR	hsa-miR-4500	88.7336	NM_002296
LBR	hsa-let-7i-5p	88.7336	NM_002296
LBR	hsa-miR-3942-3p	88.2776	NM_002296
LBR	hsa-miR-4282	87.7418	NM_002296
LBR	hsa-let-7d-5p	87.4258	NM_002296
LBR	hsa-miR-4458	87.4258	NM_002296
LBR	hsa-miR-1277-5p	84.7058	NM_002296
LBR	hsa-miR-4528	84.5815	NM_194442
LBR	hsa-miR-10527-5p	84.2706	NM_194442
LBR	hsa-miR-548an	82.8342	NM_002296
LBR	hsa-miR-4698	82.5034	NM_194442
LBR	hsa-miR-6753-5p	82.1552	NM_194442
LBR	hsa-miR-221-3p	81.8578	NM_194442
LBR	hsa-miR-222-3p	81.8578	NM_194442
LBR	hsa-miR-4700-3p	81.6285	NM_194442
LBR	hsa-miR-5197-5p	81.0779	NM_002296
LBR	hsa-miR-4697-3p	80.9635	NM_002296

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Motifs and transcription factors (TFs) regulating LBR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LBR	cisbp__M00788	ZFY (inferredBy_Orthology).
LBR	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LBR	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LBR	cisbp__M00343	PAX6 (directAnnotation).
LBR	transfac_pro__M00430	E2F1 (directAnnotation).
LBR	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
LBR	transfac_pro__M12694	ZFP14 (directAnnotation).
LBR	transfac_pro__M07437	ZBTB2 (directAnnotation).
LBR	transfac_pro__M07329	SP7 (directAnnotation).
LBR	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
LBR	transfac_pro__M01837	KLF11 (directAnnotation).
LBR	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
LBR	swissregulon__hs__KLF6	KLF6 (directAnnotation).
LBR	metacluster_163.2	ZNF682 (directAnnotation).
LBR	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
LBR	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
LBR	metacluster_22.33	MAFK (inferredBy_Orthology).
LBR	transfac_pro__M06917	ZNF236 (directAnnotation).
LBR	metacluster_22.20	MAFG (directAnnotation).
LBR	taipale_tf_pairs__ETV7_TBX21_NSCGGAARNNNNNTCACACNN_CAP_repr	ETV7; TBX21 (directAnnotation).
LBR	metacluster_26.3	ZNF232 (directAnnotation).
LBR	metacluster_80.6	ZIC4 (directAnnotation).
LBR	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
LBR	metacluster_22.17	NFE2 (directAnnotation).
LBR	metacluster_22.37	BACH1 (directAnnotation).
LBR	metacluster_22.11	NFE2 (directAnnotation).
LBR	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
LBR	metacluster_22.36	BACH2 (directAnnotation).
LBR	metacluster_22.18	BACH2 (inferredBy_Orthology).
LBR	metacluster_22.19	NFE2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."