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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KMT2C

Summary for KMT2C

Gene information	Gene symbol	KMT2C
	Ensembl ID	ENSG00000055609
	Entrez ID	58508
	Gene name	lysine methyltransferase 2C
	Synonyms	HALR\|KIAA1506\|MLL3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KMT2C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.259962	6.94e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.2975	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.432541	3.87e-17
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.291823	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.480669	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.399749	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.280068	9.10e-12
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.294252	1.80e-40

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Expression of KMT2C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KMT2C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KMT2C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KMT2C	hsa-miR-3613-3p	99.9069	NM_170606
KMT2C	hsa-miR-5688	98.9844	NM_170606
KMT2C	hsa-miR-495-3p	98.9844	NM_170606
KMT2C	hsa-miR-4262	98.7885	NM_170606
KMT2C	hsa-miR-181d-5p	97.7223	NM_170606
KMT2C	hsa-miR-181b-5p	97.7223	NM_170606
KMT2C	hsa-miR-181c-5p	97.7223	NM_170606
KMT2C	hsa-miR-181a-5p	97.7223	NM_170606
KMT2C	hsa-miR-570-3p	97.2564	NM_170606
KMT2C	hsa-miR-4495	96.5509	NM_170606
KMT2C	hsa-miR-1323	95.3717	NM_170606
KMT2C	hsa-miR-4778-5p	95.1408	NM_170606
KMT2C	hsa-miR-4671-3p	94.3535	NM_170606
KMT2C	hsa-miR-548as-3p	94.1286	NM_170606
KMT2C	hsa-miR-6809-3p	94.0075	NM_170606
KMT2C	hsa-miR-30e-5p	94.0067	NM_170606
KMT2C	hsa-miR-30d-5p	94.0067	NM_170606
KMT2C	hsa-miR-30b-5p	94.0067	NM_170606
KMT2C	hsa-miR-30c-5p	94.0067	NM_170606
KMT2C	hsa-miR-30a-5p	94.0067	NM_170606
KMT2C	hsa-miR-548o-3p	93.5027	NM_170606
KMT2C	hsa-miR-548ac	93.4096	NM_170606
KMT2C	hsa-miR-548h-3p	93.4096	NM_170606
KMT2C	hsa-miR-548z	93.4096	NM_170606
KMT2C	hsa-miR-548bb-3p	93.4096	NM_170606
KMT2C	hsa-miR-548d-3p	93.4096	NM_170606
KMT2C	hsa-miR-548aa	92.2273	NM_170606
KMT2C	hsa-miR-548ap-3p	92.2273	NM_170606
KMT2C	hsa-miR-548t-3p	92.2273	NM_170606
KMT2C	hsa-miR-12123	91.871	NM_170606
KMT2C	hsa-miR-934	91.5095	NM_170606
KMT2C	hsa-miR-5197-5p	91.441	NM_170606
KMT2C	hsa-miR-27a-3p	91.2714	NM_170606
KMT2C	hsa-miR-27b-3p	91.2714	NM_170606
KMT2C	hsa-miR-9985	91.2714	NM_170606
KMT2C	hsa-miR-651-3p	91.2347	NM_170606
KMT2C	hsa-miR-3185	91.0821	NM_170606
KMT2C	hsa-miR-194-5p	90.9134	NM_170606
KMT2C	hsa-miR-5590-5p	90.807	NM_170606
KMT2C	hsa-miR-921	89.7723	NM_170606
KMT2C	hsa-miR-1253	89.4943	NM_170606
KMT2C	hsa-miR-98-3p	89.311	NM_170606
KMT2C	hsa-let-7b-3p	89.311	NM_170606
KMT2C	hsa-let-7a-3p	89.311	NM_170606
KMT2C	hsa-let-7f-1-3p	89.311	NM_170606
KMT2C	hsa-miR-454-3p	89.2658	NM_170606
KMT2C	hsa-miR-1265	88.6704	NM_170606
KMT2C	hsa-miR-7849-3p	88.6608	NM_170606
KMT2C	hsa-miR-4666a-3p	88.5513	NM_170606
KMT2C	hsa-miR-455-3p	88.1581	NM_170606

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Motifs and transcription factors (TFs) regulating KMT2C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KMT2C	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
KMT2C	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
KMT2C	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
KMT2C	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
KMT2C	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
KMT2C	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
KMT2C	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
KMT2C	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
KMT2C	homer__AAGGKGRCGCAGGCA_ZNF165	ZNF165 (directAnnotation).
KMT2C	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWGNNNNNTCCGGNN_CAP	GCM1; SPDEF (directAnnotation).
KMT2C	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
KMT2C	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
KMT2C	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
KMT2C	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
KMT2C	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
KMT2C	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
KMT2C	transfac_pro__M07397	ZNF148 (directAnnotation).
KMT2C	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
KMT2C	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
KMT2C	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
KMT2C	cisbp__M07938	E2F1 (directAnnotation).
KMT2C	transfac_pro__M06639	ZNF559 (directAnnotation).
KMT2C	hdpi__GTF3C2	GTF3C2 (directAnnotation).
KMT2C	transfac_pro__M03806	ZBTB7C (directAnnotation).
KMT2C	transfac_pro__M05993	ZNF711 (directAnnotation).
KMT2C	hdpi__FEZF2	FEZF2 (directAnnotation).
KMT2C	hdpi__NRL	NRL (directAnnotation).
KMT2C	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
KMT2C	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
KMT2C	metacluster_155.11	SPZ1 (directAnnotation).
KMT2C	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
KMT2C	transfac_pro__M04877	GTF3C2 (directAnnotation).
KMT2C	transfac_public__M00072	TFCP2 (directAnnotation).
KMT2C	hdpi__HTATIP2	HTATIP2 (directAnnotation).
KMT2C	cisbp__M01733	CCDC169-SOHLH2; SOHLH2 (inferredBy_Orthology).
KMT2C	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
KMT2C	transfac_public__M00005	TFAP4 (directAnnotation).
KMT2C	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
KMT2C	metacluster_154.2	PAX1; PAX2; PAX2; PAX2; PAX2; PAX4; PAX4; PAX4; PAX4; PAX4; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX8; PAX8; PAX9 (directAnnotation). PAX1; PAX1; PAX1; PAX5; PAX6; PAX6 (inferredBy_Orthology).
KMT2C	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
KMT2C	jaspar__MA0131.2	HINFP (directAnnotation).
KMT2C	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
KMT2C	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."