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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HP1BP3

Summary for HP1BP3

Gene information	Gene symbol	HP1BP3
	Ensembl ID	ENSG00000127483
	Entrez ID	50809
	Gene name	heterochromatin protein 1 binding protein 3
	Synonyms	HP1-BP74
	Gene type	protein_coding
	UniProtAcc	Q5SSJ5

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Dataset with differentially expressed gene: HP1BP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.616909	6.86e-03
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.575979	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.286633	8.06e-30
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.283067	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.25522	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.257083	7.21e-34
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.449713	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.276763	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	B cells	0.829784	1.97e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.268533	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.442846	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.256866	0.00e+00

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Expression of HP1BP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HP1BP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HP1BP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HP1BP3	hsa-miR-323a-3p	99.3271	NM_016287
HP1BP3	hsa-miR-4640-5p	97.0924	NM_016287
HP1BP3	hsa-miR-185-5p	96.7581	NM_016287
HP1BP3	hsa-miR-4644	96.7581	NM_016287
HP1BP3	hsa-miR-4726-5p	96.7424	NM_016287
HP1BP3	hsa-miR-4306	96.706	NM_016287
HP1BP3	hsa-miR-4719	95.6482	NM_016287
HP1BP3	hsa-miR-12123	93.8666	NM_016287
HP1BP3	hsa-miR-7977	93.7474	NM_016287
HP1BP3	hsa-miR-373-5p	93.6762	NM_016287
HP1BP3	hsa-miR-371b-5p	93.6762	NM_016287
HP1BP3	hsa-miR-616-5p	93.6762	NM_016287
HP1BP3	hsa-miR-3662	93.0445	NM_016287
HP1BP3	hsa-miR-1-3p	91.9433	NM_016287
HP1BP3	hsa-miR-3529-3p	91.7793	NM_016287
HP1BP3	hsa-miR-577	91.6503	NM_016287
HP1BP3	hsa-miR-613	91.6087	NM_016287
HP1BP3	hsa-miR-6840-3p	91.605	NM_016287
HP1BP3	hsa-miR-7-2-3p	91.5102	NM_016287
HP1BP3	hsa-miR-7-1-3p	91.5102	NM_016287
HP1BP3	hsa-miR-1283	91.1653	NM_016287
HP1BP3	hsa-miR-206	91.0383	NM_016287
HP1BP3	hsa-miR-3119	90.7913	NM_016287
HP1BP3	hsa-miR-499a-5p	90.2573	NM_016287
HP1BP3	hsa-miR-3617-5p	89.4062	NM_016287
HP1BP3	hsa-miR-641	89.4062	NM_016287
HP1BP3	hsa-miR-208b-3p	89.0043	NM_016287
HP1BP3	hsa-miR-208a-3p	89.0043	NM_016287
HP1BP3	hsa-miR-548an	88.7489	NM_016287
HP1BP3	hsa-miR-144-5p	88.3564	NM_016287
HP1BP3	hsa-miR-636	88.231	NM_016287
HP1BP3	hsa-miR-593-5p	87.9497	NM_016287
HP1BP3	hsa-miR-9851-3p	87.9497	NM_016287
HP1BP3	hsa-miR-493-5p	87.9494	NM_016287
HP1BP3	hsa-miR-4282	87.3222	NM_016287
HP1BP3	hsa-miR-6825-5p	86.8162	NM_016287
HP1BP3	hsa-miR-12117	85.6301	NM_016287
HP1BP3	hsa-miR-1277-5p	85.6267	NM_016287
HP1BP3	hsa-miR-8063	85.5038	NM_016287
HP1BP3	hsa-miR-218-5p	85.489	NM_016287
HP1BP3	hsa-miR-6715b-5p	84.2779	NM_016287
HP1BP3	hsa-miR-6868-5p	83.6931	NM_016287
HP1BP3	hsa-miR-3127-3p	83.606	NM_016287
HP1BP3	hsa-miR-6756-3p	83.606	NM_016287
HP1BP3	hsa-miR-3613-3p	82.6005	NM_016287
HP1BP3	hsa-miR-4531	81.3688	NM_016287
HP1BP3	hsa-miR-7106-5p	80.7354	NM_016287
HP1BP3	hsa-miR-302b-3p	80.3659	NM_016287
HP1BP3	hsa-miR-520e-3p	80.3659	NM_016287
HP1BP3	hsa-miR-520b-3p	80.3659	NM_016287

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Motifs and transcription factors (TFs) regulating HP1BP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HP1BP3	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
HP1BP3	cisbp__M08228	PAX5 (directAnnotation).
HP1BP3	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
HP1BP3	transfac_pro__M00938	E2F1 (directAnnotation).
HP1BP3	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
HP1BP3	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
HP1BP3	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
HP1BP3	cisbp__M00788	ZFY (inferredBy_Orthology).
HP1BP3	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
HP1BP3	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
HP1BP3	transfac_pro__M03846	SMAD5 (directAnnotation).
HP1BP3	metacluster_45.4	E2F2 (directAnnotation).
HP1BP3	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
HP1BP3	metacluster_175.1	ZNF283 (directAnnotation).
HP1BP3	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
HP1BP3	cisbp__M00343	PAX6 (directAnnotation).
HP1BP3	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
HP1BP3	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
HP1BP3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
HP1BP3	transfac_pro__M01199	TRIM28 (directAnnotation).
HP1BP3	transfac_pro__M12694	ZFP14 (directAnnotation).
HP1BP3	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
HP1BP3	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
HP1BP3	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
HP1BP3	transfac_pro__M07387	ZBTB7A (directAnnotation).
HP1BP3	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
HP1BP3	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
HP1BP3	transfac_pro__M09837	ZNF449 (directAnnotation).
HP1BP3	transfac_pro__M00430	E2F1 (directAnnotation).
HP1BP3	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
HP1BP3	tfdimers__MD00364	WT1 (directAnnotation).
HP1BP3	hdpi__GTF3C2	GTF3C2 (directAnnotation).
HP1BP3	metacluster_198.3	ZFP64 (directAnnotation).
HP1BP3	jaspar__MA1721.1	ZNF93 (directAnnotation).
HP1BP3	transfac_pro__M08005	TCFL5 (inferredBy_Orthology).
HP1BP3	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
HP1BP3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
HP1BP3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
HP1BP3	transfac_pro__M04646	FOXN4 (directAnnotation).
HP1BP3	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
HP1BP3	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
HP1BP3	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
HP1BP3	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
HP1BP3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
HP1BP3	transfac_pro__M04617	ZBTB7A (directAnnotation).
HP1BP3	transfac_pro__M01858	TFAP2B (directAnnotation).
HP1BP3	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
HP1BP3	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
HP1BP3	metacluster_135.11	NR2C2 (directAnnotation).
HP1BP3	transfac_pro__M07437	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HP1BP3	"Artenimol"	DB11638	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."