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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: FRYL

Summary for FRYL

Gene information	Gene symbol	FRYL
	Ensembl ID	ENSG00000075539
	Entrez ID	285527
	Gene name	FRY like transcription coactivator
	Synonyms	AF4p12\|DKFZp686E205\|KIAA0826\|MOR2
	Gene type	protein_coding
	UniProtAcc	O94915

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Dataset with differentially expressed gene: FRYL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.45611	4.66e-38
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.283531	4.47e-07
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.267696	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.263102	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.334254	5.75e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.58687	5.74e-29

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Expression of FRYL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to FRYL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating FRYL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
FRYL	hsa-miR-627-3p	99.8977	NM_015030
FRYL	hsa-miR-5692a	98.9096	NM_015030
FRYL	hsa-miR-1265	98.3596	NM_015030
FRYL	hsa-miR-6730-5p	98.0319	NM_015030
FRYL	hsa-miR-656-3p	97.7434	NM_015030
FRYL	hsa-miR-3613-3p	97.5654	NM_015030
FRYL	hsa-miR-4735-3p	95.1528	NM_015030
FRYL	hsa-miR-18a-5p	95.1528	NM_015030
FRYL	hsa-miR-18b-5p	95.1528	NM_015030
FRYL	hsa-miR-126-5p	94.6626	NM_015030
FRYL	hsa-miR-4795-3p	94.5399	NM_015030
FRYL	hsa-miR-302c-5p	94.4092	NM_015030
FRYL	hsa-miR-664a-3p	94.1579	NM_015030
FRYL	hsa-miR-5690	94.0348	NM_015030
FRYL	hsa-miR-101-5p	93.255	NM_015030
FRYL	hsa-miR-216a-3p	93.1984	NM_015030
FRYL	hsa-miR-128-3p	93.1984	NM_015030
FRYL	hsa-miR-3140-5p	92.7728	NM_015030
FRYL	hsa-miR-582-5p	92.3453	NM_015030
FRYL	hsa-miR-579-3p	92.1099	NM_015030
FRYL	hsa-miR-664b-3p	92.1099	NM_015030
FRYL	hsa-miR-6514-5p	92.0336	NM_015030
FRYL	hsa-miR-3163	91.8022	NM_015030
FRYL	hsa-miR-3681-3p	91.7401	NM_015030
FRYL	hsa-miR-153-5p	90.9314	NM_015030
FRYL	hsa-miR-9-5p	90.6202	NM_015030
FRYL	hsa-miR-6838-3p	90.3738	NM_015030
FRYL	hsa-miR-6778-5p	90.3672	NM_015030
FRYL	hsa-miR-1233-5p	90.3672	NM_015030
FRYL	hsa-miR-6844	90.1662	NM_015030
FRYL	hsa-miR-8485	89.2585	NM_015030
FRYL	hsa-miR-450b-5p	88.8432	NM_015030
FRYL	hsa-miR-518c-5p	88.7237	NM_015030
FRYL	hsa-miR-2355-5p	88.1409	NM_015030
FRYL	hsa-miR-5696	87.4395	NM_015030
FRYL	hsa-miR-5691	87.1437	NM_015030
FRYL	hsa-miR-6805-3p	87.1437	NM_015030
FRYL	hsa-miR-101-3p	86.8187	NM_015030
FRYL	hsa-miR-9983-3p	86.2299	NM_015030
FRYL	hsa-miR-129-5p	86.2299	NM_015030
FRYL	hsa-miR-455-3p	85.9351	NM_015030
FRYL	hsa-miR-6891-5p	85.9279	NM_015030
FRYL	hsa-miR-5100	85.864	NM_015030
FRYL	hsa-miR-6882-3p	85.8321	NM_015030
FRYL	hsa-miR-6868-3p	85.5643	NM_015030
FRYL	hsa-miR-3173-3p	85.4979	NM_015030
FRYL	hsa-miR-12118	85.4979	NM_015030
FRYL	hsa-miR-12122	85.2794	NM_015030
FRYL	hsa-miR-527	85.1185	NM_015030
FRYL	hsa-miR-548aw	85.1185	NM_015030

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Motifs and transcription factors (TFs) regulating FRYL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
FRYL	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
FRYL	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
FRYL	transfac_pro__M07329	SP7 (directAnnotation).
FRYL	transfac_pro__M04617	ZBTB7A (directAnnotation).
FRYL	transfac_pro__M07436	WT1 (directAnnotation).
FRYL	transfac_pro__M01858	TFAP2B (directAnnotation).
FRYL	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
FRYL	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
FRYL	transfac_pro__M05993	ZNF711 (directAnnotation).
FRYL	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
FRYL	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
FRYL	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
FRYL	transfac_pro__M07437	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."